Zhang, Xinli Lu, Jue Liu, Xiaoming Sun, Peng Qin, Qian Xiang, Zhengdong Cheng, Lan Zhang, Xiaoxiao Guo, Xiaotong Wang, Jing
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Published in
Frontiers in Oncology
Objectives To comprehensively and noninvasively predict glioma grade, IDH mutation status, 1p/19q codeletion status, and MGMT promoter methylation status using chemical exchange saturation transfer (CEST)-based tumor pH assessment and metabolic profiling. Methods We analyzed 128 patients with pathologically confirmed adult diffuse glioma. CEST-deri...
Nichetti, Federico Silvestri, Marco Agnelli, Luca Franza, Andrea Pircher, Chiara Rota, Simone Ambrosini, Paolo Fotia, Giuseppe Hüllein, Jennifer Randon, Giovanni
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Published in
Cancer medicine
The identification of actionable molecular targets of pancreatic cancer (PAC) is key to improving patient outcomes. We hypothesized O6-methylguanine-DNA methyltransferase (MGMT) silencing may occur in a subset of PAC tumors, with unexplored clinical and molecular correlates. We leveraged sequencing data from The Cancer Genome Atlas (TCGA), the Clin...
Modestov, Alexander Jovchevska, Ivana Mlakar, Jernej Buzdin, Anton A.
Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy is mainly surgery and/or radiation therapy, both combined with adjuvant temozolomide (TMZ) chemotherapy. Historically, methylation of MGMT gene promoter is used as the major biomarker predicting individual tumor response to TM...
Mili, Manel Ben Abdallah, Asma Kerkeni, Asma Bedoui, Mohamed Hedi
Predicting the methylation status of the MGMT promoter in glioblastoma (GBM) is critical for optimizing temozolomide (TMZ) treatment. This study investigates an ensemble machine learning approach that integrates clinical and molecular data to achieve more accurate and reliable predictions of MGMT status. By combining multiple models to fully levera...
macagno, marco pessei, valeria congiusta, noemi lazzari, luca bellomo, sara erika idrees, fariha cavaliere, alessandro pietrantonio, filippo raimondi, alessandra gusmaroli, eleonora
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Background: O-6-methylguanine-DNA methyltransferase is responsible for the direct repair of O6-methylguanine lesions induced by alkylating agents, including temozolomide. O-6-methylguanine-DNA methyltransferase promoter hypermethylation is a well-established biomarker for temozolomide response in glioblastoma patients, also correlated with therapeu...
Roth, Patrick Gorlia, Thierry Reijneveld, Jaap C de Vos, Filip Idbaih, Ahmed Frenel, Jean-Sébastien Le Rhun, Emilie Sepulveda, Juan Manuel Perry, James Masucci, G Laura
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BackgroundStandard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as a central biological hub in tumor cells. Marizomib is a novel pan-proteasome inhibitor that c...
Roth, Patrick Gorlia, Thierry Reijneveld, Jaap C de Vos, Filip Idbaih, Ahmed Frenel, Jean-Sébastien Le Rhun, Emilie Sepulveda, Juan Manuel Perry, James Masucci, G Laura
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peer reviewed / [en] BACKGROUND: Standard treatment for patients with newly diagnosed glioblastoma includes surgery, radiotherapy (RT), and temozolomide (TMZ) chemotherapy (TMZ/RT→TMZ). The proteasome has long been considered a promising therapeutic target because of its role as a central biological hub in tumor cells. Marizomib is a novel pan-prot...
yaakub, hanum howell, anthony margison, geoffrey p. povey, andrew c.
Humans are unavoidably exposed to numerous different mutagenic DNA alkylating agents (AAs), but their role in the initiation of cancers is uncertain, in part due to difficulties in assessing human exposure. To address this, we have developed a screening method that measures promutagenic O6-alkylguanines (O6-AlkGs) in DNA and applied it to human DNA...
de almeida, gonçalo borges pascuzzo, riccardo mambrin, francesca aquino, domenico verri, mattia moscatelli, marco del bene, massimiliano dimeco, francesco silvani, antonio pollo, bianca
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Amide Proton Transfer-weighted (APTw) imaging is a molecular MRI technique used to quantify protein concentrations in gliomas, which have heterogeneous components with varying cellularity and metabolic activity. This study aimed to assess the correlation between the component-specific APT signal of the neoplasm and WHO grade, molecular profile and ...
Bao, Jing Sun, Rui Pan, Zhenjiang Wei, Shepeng
Published in
Frontiers in Oncology
Introduction Glioblastoma, despite advancements in molecular evolution, remains incurable and has low survival rates. Currently, two of the most commonly used chemotherapy regimens are temozolomide and CCNU. This review aims to provide a comprehensive analysis of the current status of chemotherapy strategies for GBM. Methods We reviewed the publish...
