Muhamadali, Howbeer; Simoens, Kenneth; 72453; Xu, Yun; Nicolai, Bart; 14537; Bernaerts, Kristel; 6977; Goodacre, Royston;
In the past two decades, metabolomics has proved to be a valuable tool with many potential applications in different areas of science. However, there are still some challenges that need to be addressed, particularly for multicenter studies. These challenges are mainly attributed to various sources of fluctuation and unwanted variations that can be ...
Willems, Thomas De Mol, Maarten L. De Bruycker, Aleksandar De Maeseneire, Sofie L. Soetaert, Wim K.
Published in
Antibiotics
Resistance of pathogenic microorganisms against antimicrobials is a major threat to contemporary human society. It necessitates a perpetual influx of novel antimicrobial compounds. More specifically, Gram− pathogens emerged as the most exigent danger. In our continuing quest to search for novel antimicrobial molecules, alkaloids from marine fungi s...
Francis, Frédéric Druart, Florent Mavungu, José Diana Di De Boevre, Marthe De Saeger, Sarah Delvigne, Frank
Published in
Microorganisms
Two fungi, i.e., Aspergillus flavus Link and Aspergillus oryzae (Ahlb.) E. Cohn, were cultivated according to two methodologies, namely submerged and biofilm cultures with the primary aim to use their secondary metabolites the supernatant CL50, and CL90 varied between 1.3% ( v/v ) to 12.7% ( v/v ) for incubation times from 24 to 72 h. While the A. ...
El Hage, Racha Hernandez-Sanabria, Emma Calatayud Arroyo, Marta Van de Wiele, Tom
Published in
American journal of physiology. Endocrinology and metabolism
Gut-liver cross talk is an important determinant of human health with profound effects on energy homeostasis. While gut microbes produce a huge range of metabolites, specific compounds such as short-chain fatty acids (SCFAs) can enter the portal circulation and reach the liver (Brandl K, Schnabl B. Curr Opin Gastroenterol 33: 128-133, 2017), a cent...
Peersman, Nele; Van Elslande, Jan; Lepage, Yannick; De Amicis, Samira; Desmet, Koenraad; Vermeersch, Pieter; 35259;
Background Our goal was to develop a simple, rapid and precise ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of retinol and α-tocopherol in serum. Currently published LC-MS/MS methods either require complex extraction procedures (liquid-liquid or solid-phase) or do not meet desirable spec...
Van De Winkel, Nele; 120514; Yurtkap, Yagmur; Dhooghe, Vicky; Huang, Shengyun; Malarvannan, Govindan; Van den Mooter, Guy; 6817; Covaci, Adrian; Van Schepdael, Ann; 16462; Miserez, Marc; 11850;
status: published
Li, Jing; 114186; Copmans, Danielle; 85665; Partoens, Michele; Hunyadi, Borbala; Luyten, Walter; 43285; de Witte, Peter; 19564;
With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine (TCM) against epilepsy. Of the six extracts that tested positive in a pentylenetetrazole (PTZ) behavioral zebrafish model, only th...
Vidal, Arnau Bouzaghnane, Nabila De Saeger, Sarah De Boevre, Marthe
Published in
Toxins
Deoxynivalenol is one of the most ubiquitous mycotoxins in the Western diet through its presence in cereals and cereal products. A vast amount of studies indicate the worrying level of exposure to this toxin, while even high percentages of the population exceed the tolerable daily intake. To evaluate and assess dietary exposure, analysis of urinary...
De Wilde, Laurie Roels, Kris Van Renterghem, Pieter Van Eenoo, Peter Deventer, Koen
PARK, SANG KI long, nguyen phuoc NGHI, TRAN Kang, Yun Pyo anh, nguyen hoang Kim, Hyung Min Kwon, Sung Won
Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study. Furthermore, the demand for logistics, instrumentations, and computational resources for metabolic phenotyping studies has far exceeded our expectations. In this conceptual review, we will ...