Ayoub, Nehad M. Alkhalifa, Amer E. Ibrahim, Dalia R. Alhusban, Ahmed
Published in
Medical Oncology
Hormone-dependent breast cancer is the most abundant molecular subtype of the disease. Despite the availability of endocrine treatments, the use of these drugs is limited by their serious adverse reactions and development of acquired resistance often mediated by growth factor receptors. The hepatocyte growth factor receptor, MET, is a receptor tyro...
Modica, Chiara Basilico, Cristina Chiriaco, Cristina Borrelli, Nicla Comoglio, Paolo M. Vigna, Elisa
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundThe receptor encoded by the MET oncogene and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic behavior. In a number of instances genetic alterations result in ligand-independent onset of malignancy (MET addiction). More frequently, ligand stimulation of wild-type MET contributes to progression toward me...
Joosten, Sander P J Spaargaren, Marcel Clevers, Hans Pals, Steven T
Published in
Biochimica et biophysica acta. Reviews on cancer
Intestinal epithelial self-renewal is a tightly controlled process, which is critically dependent on WNT signalling. Aberrant activation of the WNT pathway in intestinal stem cells (ISCs) results in constitutive transcription of target genes, which collectively drive malignant transformation in colorectal cancer (CRC). However, the contribution of ...
Yao, Hang-Ping Hudson, Rachel Wang, Ming-Hai
Published in
Biochimica et biophysica acta. Reviews on cancer
Advanced epithelial cancers such as gastric, lung, and pancreatic tumors are featured by invasive proliferation, distant metastasis, acquired chemoresistance, and tumorigenic stemness. For the last decade, molecular-targeted therapies using therapeutic antibodies, small molecule kinase inhibitors and immune-checkpoint blockades have been applied fo...
Watanabe, Satoru Ishida, Yoshiki Miura, Daisuke Miyasaka, Taira Shinya, Akikazu
Published in
Polymers
For evaluating the impact strength of dental materials, the Izod test or Charpy test has been used, but specimen preparation for these tests is difficult due to the adjustment of a notch on them. By contrast, a weight-drop impact test does not require notched specimens. Therefore, it might be possible to measure the impact strength more accurately ...
Yin, Wei Cheng, Joanne Tang, Zhenya Toruner, Gokce Hu, Shimin Guo, Ming Robinson, Melissa Medeiros, L Jeffrey Tang, Guilin
Published in
Clinical lung cancer
The MET pathway is a promising target in patients with non-small-cell lung cancer (NSCLC). Fluorescence in situ hybridization analysis has become a standard method to detect MET amplification. However, no consensus has been reached regarding the definition of MET amplification. We aimed to find clinically meaningful cutoffs for MET amplification th...
Vallarola, Antonio Tortarolo, Massimo De Gioia, Roberta Iamele, Luisa de Jonge, Hugo de Nola, Giovanni Bovio, Enrica Pasetto, Laura Bonetto, Valentina Freschi, Mattia
...
Published in
International journal of molecular sciences
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatment. The Hepatocyte Growth Factor/Scatter Factor (HGF/SF), through its receptor MET, is one of the most potent survival-promoting factors for motor neurons (MN) and is known as a modulator of immune cell function. We recently developed a novel recombina...
Bourdas, Dimitrios I. Zacharakis, Emmanouil D.
Published in
Sports
It is well known that physical inactivity increases the risk of global death; however, the impact of the coronavirus disease 2019 (COVID-19) lockdown strategy on physical activity (PA) remains unclear. This study compared PA—i.e., daily occupation, transportation to and from daily occupation, leisure time activities, and regular sporting activities...
Hekmat, Khosro
Published in
Kompass Pneumologie
Background: The role of surgery for small cell lung cancer (SCLC) is not clear. We aimed to evaluate this issue using a population-based database. Methods: Patients diagnosed between 2004 and 2014 with SCLC staged T1–4 N0–2 M0 disease were retrieved from the Surveillance, Epidemiology, and End Results database. Propensity score matching (PSM) was u...
Horter, Susanne Schütte, Wolfgang
Published in
Kompass Pneumologie
Aims: Non-small cell lung cancer (NSCLC) patients with EGFR mutations do not respond well to checkpoint inhibitors. However, little is known about the activity of immunotherapy in NSCLC with other driver mutations. The increasing use of next-generation sequencing (NGS) leads to molecular findings that face the clinician with problems while choosing...
