Jones, Kelsey DJ Hünten-Kirsch, Barbara Laving, Ahmed MR Munyi, Caroline W Ngari, Moses Mikusa, Jenifer Mulongo, Musa M Odera, Dennis Nassir, H Samira Timbwa, Molline
...
Published in
BMC Medicine
BackgroundEnvironmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has been conceptualized as an adaptive response to excess environmental pathogen exposure. However, it is clinically similar to other inf...
Barber, Susan Thakkar, Kandarp Marvin, Vanessa Franklin, Bryony Dean Bell, Derek
Published in
BMJ open
My Medication Passport has been positively evaluated; we have a better understanding of how it is used by patients, what they are recording and how it can be an aid to dialogue about medicines with family, carers and healthcare professionals. Further development and spread is underway including an App for smartphones that will be subject to wider e...
White, Michael T Bejon, Philip Olotu, Ally Griffin, Jamie T Bojang, Kalifa Lusingu, John Salim, Nahya Abdulla, Salim Otsyula, Nekoye Agnandji, Selidji T
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Published in
BMC Medicine
BackgroundThe RTS,S malaria vaccine is currently undergoing phase 3 trials. High vaccine-induced antibody titres to the circumsporozoite protein (CSP) antigen have been associated with protection from infection and episodes of clinical malaria.MethodsUsing data from 5,144 participants in nine phase 2 trials, we explore predictors of vaccine immunog...
Watson, Samuel I. Arulampalam, Wiji Petrou, Stavros Marlow, Neil Morgan, A. S. Draper, Elizabeth S. Santhakumaran, S. Modi, N.
Objective: To examine the effects of designation and volume of neonatal care at the hospital of birth on mortality and morbidity outcomes in very preterm infants in a managed clinical network setting. Design: A retrospective, population-based analysis of operational clinical data using adjusted logistic regression and instrumental variables (IV) an...
Wingfield, Tom Boccia, Delia Tovar, Marco Gavino, Arquímedes Zevallos, Karine Montoya, Rosario Lönnroth, Knut Evans, Carlton A
Published in
PLoS medicine
Despite free TB care, having TB disease was expensive for impoverished TB patients in Peru. Incurring higher relative costs was associated with adverse TB outcome. The population attributable fraction indicated that catastrophic costs and MDR TB were associated with similar proportions of adverse outcomes. Thus TB is a socioeconomic as well as infe...
Palace, Jacqueline Robertson, Neil
Published in
The Lancet
Willis, Sarah R Ahmed, Hashim U Moore, Caroline M Donaldson, Ian Emberton, Mark Miners, Alec H van der Meulen, Jan
Published in
BMJ open
To compare the diagnostic outcomes of the current approach of transrectal ultrasound (TRUS)-guided biopsy in men with suspected prostate cancer to an alternative approach using multiparametric MRI (mpMRI), followed by MRI-targeted biopsy if positive. Clinical decision analysis was used to synthesise data from recently emerging evidence in a format ...
Smith, L Thomas, E L Bell, J D Hamer, M
Published in
BMJ open
To investigate the association between objectively measured sitting and standing, using a postural allocation technique, with MRI-assessed body composition. The present study was a cross-sectional pilot study. Participants were examined at one centre located in London, UK. Normal weight Caucasian women (30.9±6.1 years; body mass index (BMI), 22.9±3...
Donaldson, Liam J Panesar, Sukhmeet S Darzi, Ara
Published in
PLoS medicine
Our approach demonstrates the potential utility of patient safety incident reports in identifying areas of service failure and highlights opportunities for corrective action to save lives.
Treasure, Tom Monson, Kathryn Fiorentino, Francesca Russell, Christopher
Published in
BMJ (Clinical research ed.)
