van der Velden, Vincent H J Preijers, Frank Johansson, Ulrika Westers, Theresia M Dunlop, Alan Porwit, Anna Béné, Marie C Valent, Peter Te Marvelde, Jeroen Wagner-Ballon, Orianne
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Published in
Cytometry. Part B, Clinical cytometry
Flow cytometry (FCM) aids the diagnosis and prognostic stratification of patients with suspected or confirmed myelodysplastic syndrome (MDS). Over the past few years, significant progress has been made in the FCM field concerning technical issues (including software and hardware) and pre-analytical procedures. Recommendations are made based on the ...
Westers, Theresia M Saft, Leonie van der Velden, Vincent H J Te Marvelde, Jeroen G Dunlop, Alan Ireland, Robin Valent, Peter Porwit, Anna Béné, Marie C van de Loosdrecht, Arjan A
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Published in
Cytometry. Part B, Clinical cytometry
Current guidelines recommend flow cytometric analysis as part of the diagnostic assessment of patients with cytopenia suspected for myelodysplastic syndrome. Herein we describe the complete work-up of six cases using multimodal integrated diagnostics. Flow cytometry assessments are illustrated by plots from conventional and more recent analysis too...
Yasuda, Hajime Hatano, Taku Honda, Tadahiro Tsutsui, Miyuki Hattori, Nobutaka Ando, Miki Komatsu, Norio
Published in
Internal medicine (Tokyo, Japan)
Vitamin B6 (VB6) is essential to heme synthesis, and its deficiency can lead to anemia. VB6 deficiency anemia is typically microcytic, hypochromic, and sideroblastic. VB6 deficiency is a well-recognized complication of levodopa/carbidopa therapy, as metabolism of levodopa to dopamine is VB6-dependent, and carbidopa irreversibly forms bonds and deac...
Aubrey, Brandon J Brunner, Andrew M
Published in
Clinical lymphoma, myeloma & leukemia
Higher-risk myelodysplastic syndromes (MDS) carry a dismal prognosis with rapid disease progression, disease-related complications that impact quality of life, high risk of transformation to acute myeloid leukemia (AML), and poor long-term survival. Higher-risk disease is determined by a number of factors including the depth and type of cytopenias,...
Zhang, Yao Qian, Yan Song, Lu-xi Xiao, Chao Chang, Chun-kang
Published in
Frontiers in Oncology
Objective To investigate the effect of iron overload (IO) on red blood cell (RBC) lifespan in MDS patients with the use of carbon monoxide breath test Methods The red blood cell lifespan of 93 patients with myelodysplastic syndrome (MDS) and 22 healthy volunteers in the control group were measured by alveolar gas carbon monoxide (CO) assay, with th...
Vyas, Hrushikesh Alcheikh, Ahmad Lowe, Gillian Stevenson, William S Morgan, Neil V Rabbolini, David J
Published in
Platelets
ANKRD26 is a highly conserved gene located on chromosome 10p12.1 which has shown to play a role in normal megakaryocyte differentiation. ANKRD26-related thrombocytopenia, or thrombocytopenia 2, is an inherited thrombocytopenia with mild bleeding diathesis resulting from point mutations the 5'UTR of the ANKRD26 gene. Point mutations in the 5'UTR reg...
Chandhok, Namrata S Sekeres, Mikkael A
Published in
Leukemia & lymphoma
Myelodysplastic syndromes (MDS) are a heterogeneous spectrum of clonal stem cell disorders characterized by ineffective hematopoiesis and resulting peripheral blood cytopenias. Clinical manifestations of the disorder are varied and range from mild asymptomatic anemia to a markedly truncated life expectancy, underscoring the importance of risk-adapt...
Kontandreopoulou, Christina-Nefeli Kalopisis, Konstantinos Viniou, Nora-Athina Diamantopoulos, Panagiotis
Published in
Frontiers in Oncology
Genomic instability, microenvironmental aberrations, and somatic mutations contribute to the phenotype of myelodysplastic syndrome and the risk for transformation to AML. Genes involved in RNA splicing, DNA methylation, histone modification, the cohesin complex, transcription, DNA damage response pathway, signal transduction and other pathways cons...
Sallman, David A
Published in
Clinical lymphoma, myeloma & leukemia
O'Hagan Henderson, Samantha Frietsch, Jochen J Hilgendorf, Inken Hochhaus, Andreas Köhne, Claus-Henning Casper, Jochen
Published in
Journal of cancer research and clinical oncology
Treosulfan and fludarabine (Treo/Flu) were successfully introduced into toxicity-reduced conditioning for SCT. However, the risk of post-SCT relapse remains a matter of concern. We report the results of a novel individual treatment approach with Treo/Flu and cytarabine (Treo/Flu/AraC) conditioning prior to allogeneic SCT in patients with acute myel...
