Schubert, Nil A Schild, Linda van Oirschot, Stijn Keller, Kaylee M Alles, Lindy K Vernooij, Lindy Nulle, Marloes E Dolman, M Emmy M van den Boogaard, Marlinde L Molenaar, Jan J
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Published in
European journal of cancer (Oxford, England : 1990)
Despite intensive treatment protocols and recent advances, neuroblastomas still account for approximately 15% of all childhood cancer deaths. In contrast with adult cancers, p53 pathway inactivation in neuroblastomas is rarely caused by p53 mutation but rather by altered MDM2 or p14ARF expression. Moreover, neuroblastomas are characterised by high ...
Tran, Hung N. Singh, Hardeep P. Guo, Wenxuan Cambier, Linda Riggan, Luke Shackleford, Gregory M. Thornton, Matthew E. Grubbs, Brendan H. Erdreich-Epstein, Anat Qi, Dong-Lai
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Published in
Frontiers in Oncology
MYC family oncoproteins MYC, MYCN, and MYCL are deregulated in diverse cancers and via diverse mechanisms. Recent studies established a novel form of MYCN regulation in MYCN-overexpressing retinoblastoma and neuroblastoma cells in which the MDM2 oncoprotein promotes MYCN translation and MYCN-dependent proliferation via a p53-independent mechanism. ...
Brown-Suedel, Alexandra N. Bouchier-Hayes, Lisa
Published in
Frontiers in Cell and Developmental Biology
Caspase-2 belongs to the caspase family of proteins responsible for essential cellular functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as a tumor suppressor, but how it regulates this function is still unknown. For many years, caspase-2 has been considered an “orphan” caspase because, although it is able to i...
Luo, Ke-Wang Zhu, Xiao-hong Zhao, Ting Zhong, Jin Gao, Han-chao Luo, Xin-Le Huang, Wei-Ren
Published in
Frontiers in Cell and Developmental Biology
Doxorubicin (DOX), the first-line chemotherapy for bladder cancer, usually induces side effects. We previously demonstrated that green tea polyphenol EGCG had potent anti-tumor effect in bladder cancer via down regulation of NF-κB. This study aimed to investigate the additive/synergistic effect EGCG and DOX against bladder cancer. Our results demon...
Boanimbek, B. Aznague, Y. El Moula, A. Abkari, I. Benhima, M.A. Saidi, H.
Published in
International Journal of Surgery Case Reports
Introduction Primary bone liposarcoma are extremely rare tumors and their location in the fibular head is exceptional. Case report A 19 year-old patient with a pain on the lateral of the proximal leg. The X-ray found an osteolytic lesion; MRI of the knee revealed a proximal epiphyseal-metaphyseal lesion process of the right fibula contours with cor...
Wang, Wei Wang, Xinjie Rajaei, Mehrdad Youn, Ji Youn Zafar, Atif Deokar, Hemantkumar Buolamwini, John K. Yang, Jianhua Foster, Jennifer H. Zhou, Jia
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Published in
Cancers
Simple Summary Neuroblastoma is a malignant tumor of the sympathetic nervous system that causes aggressive disease in children. The overall survival rate of high-risk patients is very low, therefore developing effective and safe therapies for neuroblastoma is an urgent unmet medical need. The mouse double minute 2 (MDM2) homolog gene is amplified a...
Zhang, Xiaoshan Zhang, Ran Chen, Huiqin Wang, Li Ren, Chenghui Pataer, Apar Wu, Shuhong Meng, Qing H Ha, Min Jin Morris, Jeffrey
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Published in
American Journal of Cancer Research
Activating mutations of the KRAS gene are one of the major genomic alterations associated with tumorigenesis of non-small cell lung cancer (NSCLC). Thus far, treatment of KRAS-mutant NSCLC remains an unmet medical need. We determined the in vivo treatment responses of 13 KRAS mutant and 14 KRAS wild type NSCLC patient-derived xenografts (PDXs) to a...
Yang, Xiaoqiu Xin, Nana Qu, Hai-Jun Wei, Lina Han, Zhiwu
Published in
Anatomical record (Hoboken, N.J. : 2007)
Ovarian cancer (OC) is one of the most aggressive female cancers in the world. OC trends to be diagnosed at an advanced stage with abdominal metastasis. Our study explored the biological function and underlying mechanism of lncRNA on OC cell proliferation and migration. The expression of turine up-regulated gene 1 (TUG1) in human OC tissues and cel...
Liu, Lili Yan, Jiadong Cao, Ying Yan, Yan Shen, Xiang Yu, Binbin Tao, Li Wang, Shusheng
Published in
Oncology Letters
Breast cancer is the second most common cause of cancer-associated mortality among women worldwide, and triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Berbamine (BBM) is a traditional Chinese medicine used for the treatment of leukopenia without any obvious side effects. Recent reports found that BBM has anti-...
Tamkus, Saule Gusho, Charles A. Colman, Matthew W. Miller, Ira Gitelis, Steven Blank, Alan T.
Published in
Orthopedic Reviews
Adipocytic tumors exist either as a benign or malignant form. The benign variant, lipoma, is composed of normal fat tissue. Lipomas typically develop from superficial fat cells beneath the skin or mucous membranes. Liposarcoma, the malignant counterpart, often develops in deeper tissues and is the most commonly diagnosed Soft Tissue Sarcoma (STS), ...
