Izzi, Benedetta; Tirozzi, Alfonsina; Cerletti, Chiara; Donati, Maria Benedetta; de Gaetano, Giovanni; Hoylaerts, Marc F; 12701; Iacoviello, Licia; Gialluisi, Alessandro;
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neur...
Maj, Mario; Stein, Dan J; Parker, Gordon; Zimmerman, Mark; Fava, Giovanni A; De Hert, Marc; 55530; Demyttenaere, Koen; 9125; McIntyre, Roger S; Widiger, Thomas; Wittchen, Hans-Ulrich;
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Depression is widely acknowledged to be a heterogeneous entity, and the need to further characterize the individual patient who has received this diagnosis in order to personalize the management plan has been repeatedly emphasized. However, the research evidence that should guide this personalization is at present fragmentary, and the selection of ...
Van de Velde, Nele Kappen, Mitchel Koster, Ernst H. W. Hoorelbeke, Kristof Tandt, Hannelore Verslype, Pieter Baeken, Chris De Raedt, Rudi Lemmens, Gilbert Vanderhasselt, Marie-Anne
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Published in
BMC Psychiatry
BackgroundMajor depressive episode (MDE) is worldwide one of the most prevalent and disabling mental health conditions. In cases of persistent non-response to treatment, electroconvulsive therapy (ECT) is a safe and effective treatment strategy with high response rates. Unfortunately, longitudinal data show low sustained response rates with 6-month...
Schiweck, Carmen; Claes, Stephan; Van Oudenhove, Lukas; 27997; Lafit, Ginette; 119584; Vaessen, Thomas; 106722; de Beeck, Gommaar Op; Berghmans, Raf; Wijkhuijs, Annemarie; Mueller, Norbert; Arolt, Volker;
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Circulating monocytes contribute to inflammatory processes. We here validate abnormal expression of inflammation-related genes in monocytes of a large and well-characterised group of MDD patients, and relate the outcomes to pertinent clinical characteristics. Thirty-two genes of a previously established inflammation-related gene signature were asse...
Choi, I Ho, N Morris, R Harvey, SB Calvo, RA Glozier, N
Aim Risk algorithms predicting personal mental ill‐health will form an important component of digital and personalized preventive interventions, yet it is unknown whether informing people of personal risk may cause unintended harm. This trial evaluated the comparative effect of communicating personal mental ill‐health risk profiles on psychological...
Williams, R Farquharson, L Rhodes, E Dang, M Fitzpatrick, N Quirk, A Baldwin, DS Crawford, MJ
Introduction Concerns have been raised about the quality of inpatient care received by patients with a diagnosis of personality disorder. Objectives The aim of this study was to examine the quality of care received by inpatients with an anxiety or depressive disorder, comparing subgroups with or without a co‐morbid personality disorder. Method We u...
Akingbuwa, WA Hammerschlag, AR Jami, ES Allegrini, AG Karhunen, V Sallis, H Ask, H Askeland, RB Baselmans, B Diemer, E
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Importance Adult mood disorders are often preceded by behavioral and emotional problems in childhood. It is yet unclear what explains the associations between childhood psychopathology and adult traits. Objective To investigate whether genetic risk for adult mood disorders and associated traits is associated with childhood disorders. Design, Settin...
Borrione, Lucas Bellini, Helena Razza, Lais Boralli Avila, Ana G. Baeken, Chris Brem, Anna-Katharine Busatto, Geraldo Carvalho, Andre F. Chekroud, Adam Daskalakis, Zafiris J.
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Published in
Brazilian Journal of Psychiatry
Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcra...
Wiels, Wietse Baeken, Chris Engelborghs, Sebastiaan
Background Depression and dementia are common incapacitating diseases in old age. The exact nature of the relationship between these conditions remains unclear, and multiple explanations have been suggested: depressive symptoms may be a risk factor for, a prodromal symptom of, or a coincidental finding in dementia. They may even be unrelated or onl...
Hudson, Anna Orlemann, Corinne Van Tricht, Tine Brass, Marcel Müller, Sven
Background: Depressive symptoms are associated with impaired social functioning, arguably because of reduced mentalizing abilities. However, findings in persons with depressive symptoms and/or major depressive disorder (MDD) are presently mixed, finding evidence both for and against the hypothesis of reduced mentalizing abilities. Aims: This study ...