Nishimura, Wataru Iwasa, Hiroaki Tumurkhuu, Munkhtuya
Published in
International Journal of Molecular Sciences
Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in diabetes mellitus. Recent studies provide strong evidence that the mature phenotype of β-cells is maintained by several transcription factors. These factors are also requ...
fottner;, christian
Adult-onset familial insulinomatosis is a rare disorder with recurrent, severe hypoglycemia caused by multiple insulin-secreting pancreatic tumors. The etiology was unclear until the variant p.Ser64Phe in the transcription factor MAFA, a key coordinator of β-cell insulin secretion, was defined as the cause in two families. We here describe detailed...
Cataldo, Luis Rodrigo Singh, Tania Achanta, Kavya Bsharat, Sara Prasad, Rashmi B Luan, Cheng Renström, Erik Eliasson, Lena Artner, Isabella
Published in
Acta physiologica (Oxford, England)
Reduced expression of exocytotic genes is associated with functional defects in insulin exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) development. MAFA and MAFB transcription factors regulate β-cell physiology, and their gene expression is reduced in T2D β cells. We investigate if loss of MAFA and MAFB in human β c...
Walker, Emily M Cha, Jeeyeon Tong, Xin Guo, Min Liu, Jin-Hua Yu, Sophia Iacovazzo, Donato Mauvais-Jarvis, Franck Flanagan, Sarah E Korbonits, Márta
...
Published in
Cell reports
A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or insulinomatosis), with men more prone to diabetes than women. This mutation engenders increased stability to the unstable MAFA protein. Here, we develop a S64F MafA mouse m...
Lei, Lei Bai, Yi-Hua Jiang, Hong-Ying He, Ting Li, Meng Wang, Jia-Ping
Published in
Endocrine connections
N6-methyladenosine (m6A) methylation has been reported to play a role in type 2 diabetes (T2D). However, the key component of m6A methylation has not been well explored in T2D. This study investigates the biological role and the underlying mechanism of m6A methylation genes in T2D. The Gene Expression Omnibus (GEO) database combined with the m6A me...
Deng, Zhaobin Matsumoto, Yuka Kuno, Akihiro Ojima, Masami Xiafukaiti, Gulibaikelamu Takahashi, Satoru
Published in
International Journal of Molecular Sciences
Diabetes mellitus is an increasingly severe chronic metabolic disease that is occurring at an alarming rate worldwide. Various diabetic models, including non-obese diabetic mice and chemically induced diabetic models, are used to characterize and explore the mechanism of the disease’s pathophysiology, in hopes of detecting and identifying novel pot...
Yang, Wenhao Liu, Yue Liu, Fanming
Published in
Sensors (Basel, Switzerland)
The solution of carrier phase ambiguity is essential for precise global navigation satellite system (GNSS) positioning. Methods of searching in the coordinate domain show their advantage over the methods based on ambiguity fixing, for example, immune to cycle slips, far fewer epochs taken for obtaining the precise solution. However, there are still...
Zhu, Yaxi Tonne, Jason M. Liu, Qian Schreiber, Claire A. Zhou, Zhiguang Rakshit, Kuntol Matveyenko, Aleksey V. Terzic, Andre Wigle, Dennis Kudva, Yogish C.
...
Published in
Stem Cell Reports
In this article, Ikeda Yasuhiro and colleagues show that stepwise transduction of the triad of transcription factors PDX1, NEUROG3, and MAFA (PNM) enabled in vitro generation of glucose- and GLP-1-responsive β cells from iPSCs within 3 weeks. PNM transduction improves glucose sensing, insulin secretion, and β-cell maturation of generated cells. PNM...
Iacovazzo, Donato Flanagan, Sarah E Walker, Emily Quezado, Rosana de Sousa Barros, Fernando Antonio Caswell, Richard Johnson, Matthew B Wakeling, Matthew Brändle, Michael Guo, Min
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
The β-cell-enriched MAFA transcription factor plays a central role in regulating glucose-stimulated insulin secretion while also demonstrating oncogenic transformation potential in vitro. No disease-causing MAFA variants have been previously described. We investigated a large pedigree with autosomal dominant inheritance of diabetes mellitus or insu...
Tsuchiya, Mariko Misaka, Ryoichi Nitta, Kosaku Tsuchiya, Ken
Published in
World journal of diabetes
The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription f...
