Poly(vinyl alcohol)/Pullulan/NaCl Conductive Hydrogels with High Strength and Sensitivity for Wearable Strain Sensors
status: published
Extensibility governs the flow-induced alignment of polymers and rod-like colloids
status: published
Hydraulic conductivity of human cancer tissue : a hybrid study
Background Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IFP non-invasively. Image-based estimation of the IFP requires knowledge of the tissue hydraulic conductivity (...
Photothermal nanomaterial-mediated photoporation
Delivering biological effector molecules in cultured cells is of fundamental importance to any study or application in which the modulation of gene expression is required. Examples range from generating engineered cell lines for studying gene function to the engineering of cells for cell-based therapies such as CAR-T cells and gene-corrected stem c...
Conformational parameters and hydrodynamic behavior of poly(2-methyl-2-oxazoline) in a broad molar mass range
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In this work, we report our results on the hydrodynamic behavior of poly(2-methyl-2oxazoline) (PMeOx). PMeOx is gaining significant attention for use as hydrophilic polymer in pharmaceutical carriers as an alternative for the commonly used poly(ethylene glycol) (PEG), for which antibodies are found in a significant fraction of the human population....
Characterization of hen phosvitin in aqueous salt solutions: Size, structure, and aggregation
Phosvitins is a key egg yolk protein and can often be found in food emulsions. It is highly phosphorylated and hence phosvitins contain a large number of negatively charged amino acid groups, for pH > pI. Due to the presence of these phophoserines, phosvitins bind to positively charged multivalent ions. Its amphipolar structure makes phosvitin also...
Sequencing of uniform multifunctional oligoesters via random chain cleavages
Sequence-defined polymers have been the object of many fascinating studies that focus on their implementation in both material and life science applications. In parallel, iterative synthetic methodologies have become more efficient, whereas the structure elucidation of these molecules is generally dependent on MS/MS analysis. Here, we report an alt...
SANS Study of PPPO in mixed solvents and impact on polymer nanoprecipitation
We investigate the conformation of poly(2,6-diphenyl-p-phenylene oxide) (PPPO) in good and mixed solvents by small-angle neutron scattering (SANS) across its ternary phase diagram. Dichloromethane was selected as a “good” solvent and heptane as a “poor” solvent whose addition eventually induces demixing and polymer precipitation. Below the overlap ...
Tracking the ATP-binding response in adenylate kinase in real time.
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Published in Science advances
The biological function of proteins is critically dependent on dynamics inherent to the native structure. Such structural dynamics obey a predefined order and temporal timing to execute the specific reaction. Determination of the cooperativity of key structural rearrangements requires monitoring protein reactions in real time. In this work, we used...
Fluorine-containing block and gradient copoly(2-oxazoline)s based on 2-(3,3,3-Trifluoropropyl)-2-oxazoline : a quest for...
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The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous fluorine atoms in the body. In this work, we present a comprehensive study of the influence of the amphiphilic polymer structure and composition on its applicability as contrast agents in F-19 MRI....
