Zhang, Shilu Zhou, Huang Zhang, Liang Zhu, Caiqiong Du, Xinyi Wang, Linjing Chen, Hongyu Liu, Jun
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Supramolecular organic frameworks have been widely applied for biological detection and drug delivery. In this study, a supramolecular organic framework (SOF) is constructed through the self-assembly of a highly photosensitive triarylphosphine oxide guest molecule, OTPP-6-Methyl, with cucurbit [8] uril (CB [8]). The formation of the SOF gradually e...
Ji, Qinghong Zhang, Shulin Jiang, Wen Wang, Jue Luan, Yun Xin, Qian
Published in
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Early-onset preeclampsia (PE) is still lacking definitive diagnostic or therapeutic strategies. Thus, we tried to identify effective and specific biomarkers for early-onset PE. In this study, we explored the serum protein profiles through the approach of label-free quantitation proteomics between early-onset PE patients and healthy controls. We ide...
Balijepalli, Pravita Meier, Kathryn E
Published in
Journal of cell communication and signaling
CCN1 and CCN2 are matricellular proteins that are transcriptionally induced by various stimuli, including growth factors. CCN proteins act to facilitate signaling events involving extracellular matrix proteins. Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing proliferation, adhesion, and migration...
Centonze, Matteo Di Conza, Giusy Lahn, Michael Fabregat, Isabel Dituri, Francesco Gigante, Isabella Serino, Grazia Scialpi, Rosanna Carrieri, Livianna Negro, Roberto
...
Published in
Journal of experimental & clinical cancer research : CR
Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly correlated with stage and grade in several human cancers. Several small molecule ATX inhibitors have been developed in r...
He, Haiyue Sugiyama, Akiko Snyder, Nathaniel W Teneche, Marcos G Liu, Xiaowei Maner-Smith, Kristal M Goessling, Wolfram Hagen, Susan J Ortlund, Eric A Najafi-Shoushtari, S Hani
...
Published in
Cancer letters
Cancer cells use acetate to support the higher demand for energy and lipid biosynthesis during uncontrolled cell proliferation, as well as for acetylation of regulatory proteins. Acyl-CoA thioesterase 12 (Acot12) is the enzyme that hydrolyzes acetyl-CoA to acetate in liver cytosol and is downregulated in hepatocellular carcinoma (HCC). A mechanisti...
Maggs, Lauren
Autotaxin (ATX/ENPP2) is a secreted phospholipase D enzyme that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA is the agonist for at least six G protein coupled receptors whose activation stimulates cell proliferation, survival and migration. Overexpression of ATX and increased levels of LPA have been linked to fibroti...
Montané-Romero, Martha E. Martínez-Silva, Ana V. Poot-Hernández, Augusto C. Escalante-Alcalde, Diana
Published in
Biology Open
Summary: We discuss two novel roles of phospholipid phosphatase 3 (PLPP3), in pluripotency exit in mouse embryonic stem cells and in endodermal differentiation through the regulation of bioactive lipid signaling.
Jeong, Bo Young Cho, Kyung Hwa Jeong, Kang Jin Cho, Su Jin Won, Minho Kim, Seung Hwa Cho, Nam Hoon Hur, Gang Min Yoon, Se-Hee Park, Hwan-Woo
...
Published in
Cancer letters
Cancer-associated fibroblasts (CAFs) are key structural components of the tumor microenvironment and are closely associated with tumor invasion and metastasis. Lysophosphatidic acid (LPA) is a biolipid produced extracellularly and involved in tumorigenesis and metastasis. LPA has recently been implicated in the education and transdifferentiation of...
Wang, Qiang Gao, Zhiqiang Guo, Kai Lu, Jiawei Wang, Feng Huang, Yufeng Wu, Desheng
Published in
Journal of Orthopaedic Surgery and Research
Background Apart from the current understanding of enzyme function, the mechanism of ectonucleotide pyrophosphatase/phosphodiesterase 1 ( Enpp1 ) deficiency-associated osteoporosis is unknown. We aimed to explore the changes in the expression of signaling pathways of bone tissues involved in Enpp1 deficiency. Methods The body weights and morphology...
Wang, Shuo Chen, Jiang Guo, Xiao-Zhong
Published in
World Journal of Gastrointestinal Oncology
The KAI1/CD82 gene inhibits the metastasis of most tumors and is remarkably correlated with tumor invasion and prognosis. Cell metabolism dysregulation is an important cause of tumor occurrence, development, and metastasis. As one of the important characteristics of tumors, cell metabolism dysregulation is attracting increasing research attention. ...
