Dupin, Isabelle Eyraud, Edmée Maurat, Élise Sac-Épée, Jean-Marc Vallois, Pierre
Published in
Journal of theoretical biology
The chronic obstructive pulmonary disease (COPD) is a highly prevalent lung disease, in which unusual interactions between fibrocytes and CD8+ T lymphocytes in the peribronchial area could induce chronic inflammation and tissue remodeling. We considered a probabilistic cellular automata type model where the two types of cells follow simple local in...
Jo, Norihide Hidaka, Yu Kikuchi, Osamu Fukahori, Masaru Sawada, Takeshi Aoki, Masahiko Yamamoto, Masaki Nagao, Miki Morita, Satoshi Nakajima, Takako E.
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高齢者のT細胞応答は立ち上がりが遅く収束は早い --新型コロナワクチン接種機会を活用した免疫応答の個人差・年齢差の解明--. 京都大学プレスリリース. 2023-01-13. / T-Cell Responses in the Elderly Rise Slowly and Contract Quickly --Learning About Individual and Age Differences in Immune Response From COVID-19 Vaccinations--. 京都大学プレスリリース. 2023-01-13. / Whether age-associated defects in T cells impact the immunogenicity and...
Capasso, Nicola Palladino, Raffaele Cerbone, Vincenza Spiezia, Antonio Luca Covelli, Bianca Fiore, Antonia Lanzillo, Roberta Carotenuto, Antonio Petracca, Maria Stanziola, Lucia
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Published in
Journal of neurology
We aim to evaluate 3-year effects of ocrelizumab (humanized anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS)) on lymphocytes, neutrophils and immunoglobulins: (1) when compared with pre-infusion assessment; (2) over the course of treatment; and (3) possible clinical correlates of the observed immunological modifications. T...
Qutob, Haitham M H Saad, Ramadan A Bali, Hamza Osailan, Abdulaziz Jaber, Jumana Alzahrani, Emad Alyami, Jamilah Elsayed, Hani Alserihi, Raed Shaikhomar, Osama A
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Published in
Medicina clinica
The most effective way to control severity and mortality rate of the novel coronavirus disease (COVID-19) is through sensitive diagnostic approaches and an appropriate treatment protocol. We aimed to identify the effect of adding corticosteroid and Tocilizumab to a standard treatment protocol in treating COVID-19 patients with chronic disease throu...
Valpione, Sara Campana, Luca G Weightman, John Salih, Zena Galvani, Elena Mundra, Piyushkumar A De Rosa, Francesco Gupta, Avinash Serra-Bellver, Patricio Lorigan, Paul
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Published in
European journal of cancer (Oxford, England : 1990)
Immune cell-driven anti-cancer activity is paramount for effective responses to checkpoint inhibitors (ICB). However, the contribution of the different immune cell subsets in the circulation and within the tumour is poorly understood. To elucidate the role of the different cell subsets in anti-tumour responses elicited by ICB, we performed single-c...
Zambelli, Vanessa O Hösch, Natália Gabriele Farom, Sarah Zychar, Bianca C Spadacci-Morena, Diva D Carvalho, Luciana Vieira Curi, Rui Lepsch, Lucilia B Scavone, Cristoforo Sant'Anna, Osvaldo Augusto
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Published in
Toxicon : official journal of the International Society on Toxinology
Crotoxin (CTX) is a neurotoxin that is isolated from the venom of Crotalus durissus terrificus, which displays immunomodulatory, anti-inflammatory, and anti-tumoral effects. Previous research has demonstrated that CTX promotes the adherence of leukocytes to the endothelial cells in blood microcirculation and the high endothelial venules of lymph no...
Zhang, Cheng-Cai Liu, B Pawluski, Jodi Steinbusch, Harry W. M. Kirthana Kunikullaya, U Song, C
Excessively released proinflammatory mediators from activated macrophages and lymphocytes may contribute to the etiology of depression. However, the relationship between lymphocytes and depression is not fully understood. Although women have higher depression risk than men, sex/gender differences in psychoneuroimmunological mechanisms are still unc...
Lynall, Mary-Ellen Soskic, Blagoje Hayhurst, James Schwartzentruber, Jeremy Levey, Daniel Pathak, Gita Polimanti, Renato Gelernter, Joel Stein, Murray Trynka, Gosia
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Multiple psychiatric disorders have been associated with abnormalities in both the innate and adaptive immune systems. The role of these abnormalities in pathogenesis, and whether they are driven by psychiatric risk variants, remains unclear. We test for enrichment of GWAS variants associated with multiple psychiatric disorders (cross-disorder or t...
Gompertz-Mattar, Matias Perales, Juan Sahu, Aditi Mondaca, Sebastián Gonzalez, Sergio Uribe, Pablo Navarrete-Dechent, Cristian
Published in
Archives of dermatological research
Few studies have evaluated programmed cell death ligand (PD-L1) expression and lymphocytic infiltrates in Basal Cell Carcinoma (BCC). The objectives of this study are to assess PD-L1 expression and markers of local immune response in nodular, superficial, and morpheaform BCC, and compare it to normal, sun-exposed skin from the periphery of intrader...
Derigs, Marcus Heers, Hendrik Lingelbach, Susanne Hofmann, Rainer Hänze, Jörg
Published in
Immunologic research
Sepsis causes a myriad of immunological reactions that result in life-threatening alterations in the human body. Immunosuppression in sepsis is partly attributed to the programmed death receptor (PD-1) and its associated ligand (PD-L1) via the regulation of lymphocytes and neutrophils. Although the soluble forms of these proteins (i.e., sPD-1 and s...
