Klaourakis, Konstantinos Vieira, Joaquim M. Riley, Paul R.
Published in
Nature Reviews. Cardiology
The cardiac lymphatic vasculature appears during embryonic development and continues to mature structurally and functionally until late postnatal stages. Both venous and non-venous sources contribute to the lymphatic endothelium of the heart, and the identity of the lymphatic endothelial cells of venous origin is defined very early in development d...
Van de Velde, Maureen Ebroin, Marie Durré, Tania Joiret, Marc Gillot, Lionel Blacher, Silvia Geris, Liesbet Kridelka, Frédéric Noël, Agnès
Solid tumors are composed of tumor cells and stromal cells including lymphatic endothelial cells (LEC), which are mainly viewed as cells forming lymphatic vessels involved in the transport of metastatic and immune cells. We here reveal a new mechanism by which tumor exposed-LEC (teLEC) exert mitogenic effects on tumor cells. Our conclusions are sup...
Frenkel, Nicola C. Poghosyan, Susanna Verheem, André Padera, Timothy P. Rinkes, Inne H. M. Borel Kranenburg, Onno Hagendoorn, Jeroen
Published in
Scientific Reports
The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the importance of organ-specific lymphatics, the functional anatomy of liver lymphatics has not been mapped out. I...
Tai-Nagara, Ikue Hasumi, Yukiko Kusumoto, Dai Hasumi, Hisashi Okabe, Keisuke Ando, Tomofumi Matsuzaki, Fumio Itoh, Fumiko Saya, Hideyuki Liu, Chang
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Published in
Nature Communications
Blood and lymphatic vessels bear a strong resemblance but do not share a lumen, thus maintaining their distinct functions. Here, the authors describe that Folliculin, a tumor suppressor, prevents the fusion of these vessels during development by limiting the plasticity of venous and lymphatic endothelial cells.
Ma, Wenliang Yang, Jun Liu, Ning Pu, Xiaohong Qu, Feng Xu, Linfeng Zhao, Xiaozhi Li, Xiaogong Zhang, Gutian Guo, Hongqian
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Published in
BMC Cancer
BackgroundTumor micro-angiogenesis and lymphangiogenesis are effective prognostic predictors in many solid malignancies. However, its role on Xp11.2 translocation RCC has not been fully elucidated. Herein, we purposed to explore the correlation between quantitative parameters of tumor-related micro-angiogenesis or lymphangiogenesis and the prognosi...
Wang, Shuangyong Yamakawa, Michael Santosa, Samuel M. Chawla, Neeraj Guo, Kai Montana, Mario Hallak, Joelle A. Han, Kyu-Yeon Ema, Masatsugu Rosenblatt, Mark I.
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Published in
Protein and Peptide Letters
Abstract: Background Lymphatic vessel formation (lymphangiogenesis) plays important roles in cancer metastasis, organ rejection, and lymphedema, but the underlying molecular events remain unclear. Furthermore, despite significant overlap in the molecular families involved in angiogenesis and lymphangiogenesis, little is known about the crosstalk be...
Subileau, Mariela Acar, Niyazi Carret, Alison Bretillon, Lionel Vilgrain, Isabelle Bailly, Sabine Vittet, Daniel
Published in
Scientific Reports
Aqueous humor drainage is essential for the regulation of intraocular pressure (IOP), a major risk factor for glaucoma. The Schlemm’s canal and the non-conventional uveoscleral pathway are known to drain aqueous humor from the eye anterior chamber. It has recently been reported that lymphatic vessels are involved in this process, and that the Schle...
Hwang, Ilseon Kim, Jeong Won Ylaya, Kris Chung, Eun Joo Kitano, Haruhisa Perry, Candice Hanaoka, Jun Fukuoka, Junya Chung, Joon-Yong Hewitt, Stephen M.
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Published in
Journal of Translational Medicine
BackgroundThe tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally characterized as M2-like macrophages. TAMs are believed to contribute to tumor progression, but the mechanism behind this remains uncle...
Kondo, Reiichiro Iwakiri, Yasuko
Published in
Clinical and Molecular Hepatology
The lymphatic system plays vital roles in interstitial fluid balance and immune cell surveillance. The effect of alcohol on the lymphatic system is poorly understood. This review article explores the role of the lymphatic system in the pathogenesis of alcohol-related disease including alcoholic liver disease (ALD) and the therapeutic potential of t...
Hong, Seon Pyo Yang, Myung Jin Cho, Hyunsoo Park, Intae Bae, Hosung Choe, Kibaek Suh, Sang Heon Adams, Ralf H. Alitalo, Kari Lim, Daesik
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Published in
Nature Communications
Intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. Here the authors show that VEGF-C expression in specialized IntSCs is regulated by YAP/TAZ, and VEGF-C is responsible for maintaining lacteal integrity, thus influencing dietary fat drainage into lacteals.