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Garland, Keira Pantua, Homer Braun, Marie-Gabrielle Burdick, Daniel J Castanedo, Georgette M Chen, Yi-Chen Cheng, Yun-Xing Cheong, Jonathan Daniels, Blake Deshmukh, Gauri
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Published in
Bioorganic & medicinal chemistry letters
Discovery of novel classes of Gram-negative antibiotics with activity against multi-drug resistant infections is a critical unmet need. As an essential member of the lipoprotein biosynthetic pathway, lipoprotein signal peptidase II (LspA) is an attractive target for antibacterial drug discovery, with the natural product inhibitor globomycin offerin...
Xia, Jie Feng, Bo Wen, Gang Xue, Wenjie Ma, Guixing Zhang, Hongmin Wu, Song
Published in
Current medicinal chemistry
Antibiotic resistance is currently a serious problem for global public health. To this end, discovery of new antibacterial drugs that interact with novel targets is important. The biosynthesis of lipoproteins is vital to bacterial survival and its inhibitors have shown efficacy against a range of bacteria, thus bacterial lipoprotein biosynthetic pa...
