Lu, Tao Ma, Ke Zhan, Cheng Yang, Xiaodong Shi, Yu Jiang, Wei Wang, Hao Wang, Shuai Wang, Qun Tan, Lijie
...
Published in
Annals of Translational Medicine
Background Long noncoding RNA (lncRNA) in non-homologous end joining pathway 1 (LINP1) contributes to tumorigenesis in various cancers. However, little has been known about the role of LINP1 in esophageal squamous cell carcinoma (ESCC). Methods LINP1 was selected as the target lncRNA by bioinformatics analysis. The relationship between LINP1 expres...
Zhang, Yina Yu, Tianqi Ding, Yingnan Li, Yahui Lei, Jing Hu, Boli Zhou, Jiyong
Published in
Virologica Sinica
Long noncoding RNAs (lncRNAs) participate in regulating many biological processes. However, their roles in influenza A virus (IAV) pathogenicity are largely unknown. Here, we analyzed the expression profiles of lncRNAs and mRNAs in H3N2-infected cells and mock-infected cells by high-throughput sequencing. The results showed that 6129 lncRNAs and 50...
Zhang, Wenlu Bai, Yunmeng Chen, Zixi Li, Xingsong Fu, Shuying Huang, Lizhen Lin, Shudai Du, Hongli
Published in
PeerJ
Skeletal muscle long non-coding RNAs (lncRNAs) were reported to be involved in the development of type 2 diabetes (T2D). However, little is known about the mechanism of skeletal muscle lncRNAs on hyperglycemia of diabetic Goto-Kakizaki (GK) rats at the age of 3 and 4 weeks. To elucidate this, we used RNA-sequencing to profile the skeletal muscle tr...
Li, Dijie Yang, Chaofei Yin, Chong Zhao, Fan Chen, Zhihao Tian, Ye Dang, Kai Jiang, Shanfeng Zhang, Wenjuan Zhang, Ge
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Published in
Endocrine, metabolic & immune disorders drug targets
Bone is an important tissue and its normal function requires tight coordination of transcriptional networks and signaling pathways, and many of these networks/ pathways are dysregulated in pathological conditions affecting cartilage and bones. Long non-coding RNA (lncRNA) refers to a class of RNAs with a length of more than 200 nucleotides, lack of...
Shao, Ting-Ru Zheng, Ze-Nan Chen, Yue-Chuan Wu, Qing-Qing Huang, Guang-Zhao Li, Fei Zeng, Wei-Sen Lv, Xiao-Zhi
Published in
Life sciences
Long noncoding RNA (lncRNA) AC007271.3 has been identified to be dysregulated in oral squamous cell carcinoma (OSCC) in our previous study. However, the precise role of AC007271.3 in OSCC remains unclear. In this study, we investigated the potential functions and the underlying mechanisms of AC007271.3 in OSCC. The expression levels of AC007271.3 i...
Han, Na Yang, Li Zhang, Xiaoxi Zhou, Yangmei Chen, Rui Yu, Yang Dong, Zhen Zhang, Mengxian
Published in
Annals of Translational Medicine
Background Glioblastoma (GBM) is one of the most aggressive and malignant tumor types. Despite treatment advances, GBM pathogenesis still remains largely unknown. MATN1-AS1, an intron-retained long non-coding RNA (lncRNA), has been implicated in GBM development. However, the underlying mechanism has not been identified. This study aimed to examine ...
Jiang, Wen Guo, Qing Wang, Chenghe Zhu, Yu
Published in
Cancer Cell International
BackgroundAbnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients.Methods“edgeR” AND “DEseq” R packages were used to explore differentially expressed genes (DEGs) between normal and tumor tissues of...
Zeng, Tao Ni, Haitao Yu, Yue Zhang, Mingke Wu, Minjuan Wang, Qiaoling Wang, Liujun Xu, Sha Xu, Zhenyu Xu, Chen
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Published in
Journal of chemical neuroanatomy
Abnormal long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) participate in the pathophysiology of Alzheimer's disease (AD). However, it remains unclear whether these two types of noncoding RNAs functionally interact and which factors mediate these interactions in AD. β-secretase 1 (BACE1) is the enzyme responsible for amyloid plaque formation, wh...
Shi, Ruitang Yang, Haoqing Lin, Xiao Cao, Yangyang Zhang, Chen Fan, Zhipeng Hou, Benxiang
Published in
Stem Cell Research & Therapy
BackgroundHuman dental pulp stem cell (DPSC)-mediated regenerative endodontics is a promising therapy for damaged teeth; however, the hypoxic environment in root canals can affect tissue regeneration. In this study, we investigate the characteristics and possible regulatory mechanisms of DPSC function under hypoxic conditions.MethodsHuman DPSCs wer...
Liu, Fei Li, Tao Zhang, Liqun Xiang, Guiming Jiang, Dongneng Tu, Dianji Liu, Linlin Li, Yi Liu, Chang Pu, Xiaoyun
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Published in
Journal of Biological Engineering
AbstractMetastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non coding RNA (lncRNA) present in serum, is an important biomarker for detecting hepatocellular carcinoma (HCC). However, there are some shortcomings in current detection methods. So developing other novel MALAT1 detection methods is necessary. Electrochemical biosenso...
