Chehrehgosha, Haleh Sohrabi, Masoud Reza Ismail-Beigi, Faramarz Malek, Mojtaba Reza Babaei, Mohammad Zamani, Farhad Ajdarkosh, Hossein Khoonsari, Mahmood Fallah, Afshin Eshghi Khamseh, Mohammad E.
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Published in
Diabetes Therapy
Introduction To evaluate the efficacy of empagliflozin compared to pioglitazone in patients with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM). Methods In this prospective randomized, double-blind, placebo-controlled trial, we assigned 106 patients with NAFLD and T2DM to receive empagliflozin 10 mg ( n = 35), pioglitazone 30 ...
Wu, Yuexin Cao, Yuyan Xu, Keren Zhu, Yue Qiao, Yuemei Wu, Yanjun Chen, Jianfeng Li, Chen Zeng, Rong Ge, Gaoxiang
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Published in
Cell Death & Disease
Liver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease. Liver cirrhosis is the result of deregulated wound healing and is featured by aberrant extracellular matrix (ECM) remod...
Osawa, Yosuke Yoshio, Sachiyo Aoki, Yoshihiko Korenaga, Masaaki Imamura, Masatoshi Oide, Takashi Okawara, Miku Kawai, Hironari Tsutsui, Yuriko Yoshida, Yuichi
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Published in
BMC Gastroenterology
BackgroundPathological angiogenesis is involved in the development of hepatocellular carcinoma. In patients with chronic hepatitis C (CHC), the level of angiogenic factor angiopoietin (ANGP)-2 is reported to be increased in the blood, correlating with fibrosis. In this study, we aimed to clarify whether blood ANGP-2 is useful as a biomarker for liv...
Sharma, Sachin Ghufran, Shaikh Maryam Ghose, Sampa Biswas, Subhrajit
Published in
Scientific Reports
The activated hepatic stellate cells (HSCs) are the major cells that secrete the ECM proteins and drive the pathogenesis of fibrosis in chronic liver disease. Targeting of HSCs by modulating their activation and proliferation has emerged as a promising approach in the development of anti-fibrotic therapy. Sorafenib, a multi-kinase inhibitor has sho...
Zjacic Puljiz, Danijela Mestrovic, Antonio Zaja, Ivan Tonkic, Ante Grgurevic, Ivica Duplancic, Darko Delic Jukic, Ivana Kristina Ljutic, Dragan Puljiz, Zeljko
Published in
Wiener klinische Wochenschrift
The impact of hemodialysis on liver stiffness is still unclear. The aim of the study was to assess liver fibrosis by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to quantify the influence of net fluid withdrawal on liver stiffness during one hemodialysis session. The second aim was to investigate the influence of systolic blood...
Wang, Qing Liu, HaiFeng Zhu, ZuHui Sheng, Ye Du, YaNan Li, YuFeng Liu, JianHong Zhang, JiLei Xing, Wei
Published in
Magnetic resonance imaging
To compare the diagnostic accuracy of parameters derived from the histogram analysis of precontrast, 10-min hepatobiliary phase (HBP) and 20-min HBP T1 maps for staging liver fibrosis (LF). LF was induced in New Zealand white rabbits by subcutaneous injections of carbon tetrachloride for 4-16 weeks (n = 120), and 20 rabbits injected with saline ser...
Zou, Li-Qiu Zhao, Feng Zhang, Hao Zhang, Kai Xing, Wei
Published in
Acta radiologica (Stockholm, Sweden : 1987)
Magnetic resonance elastography (MRE), susceptibility-weighted imaging (SWI), and T1ρ are three techniques for staging of liver fibrosis (LF). To assess the value of MRE, SWI, and T1ρ imaging in staging LF. Sixty rabbits were injected with 50% CCl4oil solution, whereas 20 rabbits were given normal saline. All rabbits underwent pathological examinat...
Vitiello, Antonio La Porta, Raffaele D’Aiuto, Vilma Ferrara, Francesco
Published in
Egyptian Liver Journal
BackgroundThe global pandemic COVID-19 caused by the new coronavirus SARS-CoV-2 has already caused about 1.4 million deaths, and to date, there are no effective or direct antiviral vaccines. Some vaccines are in the last stages of testing. Overall mortality rates vary between countries, for example, from a minimum of 0.05% in Singapore to a maximum...
Nguyen, Hien Thi Thu Wimmer, Reinhard Le, Vang Quy Krarup, Henrik Bygum
Published in
Metabolomics
IntroductionChronic hepatitis B (CHB) affects 257 million individuals worldwide with an annual estimated mortality rate of 880,000 individuals. Accurate diagnosis of the stage of disease is difficult, and there is considerable uncertainty concerning the optimal point in time, when treatment should be started.ObjectivesBy analyzing and comparing the...
Son, Yang-Ju Jung, Da Seul Shin, Ji Min Kim, Myungsuk Yoo, Gyhye Nho, Chu Won
Published in
BMC Complementary Medicine and Therapies
BackgroundNonalcoholic steatohepatitis (NASH), a liver disease caused by a nonalcoholic fatty liver, is increasing in incidence worldwide. Owing to the complexity of its pathogenic mechanisms, there are no therapeutic agents for this disease yet. The ideal drug for NASH needs to concurrently decrease hepatic lipid accumulation and exert anti-inflam...
