Nozari, Elham Moradi, Ali Samadi, Morteza
Published in
Life sciences
Liver fibrosis is an inflammatory and fibrogenic process that occurs following chronic liver damage. TGFβ1 is the key inducer of fibrosis. MiR-21 and miR-122 are two miRNAs that their expression changes during fibrosis. In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and m...
Guo, Wen Lu, Jing Qin, Pei Li, Xiaona Zhu, Wenfang Wu, Juan Xu, Nianzhen Zhang, Qun
Published in
Lipids in Health and Disease
BackgroundThe triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD.MethodsA total of 4784 participants who underwent ultrasono...
Okabe, Hirohisa Yamashita, Yo-ichi Elmezayen, Hatem A. Hayashi, Hiromitsu Imai, Katsunori Baba, Hideo
Published in
Surgery Today
Lyu, Liang Liu, Xing-Li Rui, Mao-Ping Yang, Li-Chuan Wang, Guan-Zhong Fan, Dong Wang, Tony Zheng, Jie
Published in
European radiology
This study was to evaluate the diagnostic value of liver extracellular volume (LECV) for the staging of liver fibrosis in a cynomolgus monkey model of nonalcoholic steatohepatitis (NASH). Forty-eight cynomolgus monkeys were enrolled in this prospective study. There are 17 healthy monkeys and 31 monkeys with NASH. Ten of these monkeys were used for ...
Okina, Yoshinori Sato-Matsubara, Misako Matsubara, Tsutomu Daikoku, Atsuko Longato, Lisa Rombouts, Krista Thanh Thuy, Le Thi Ichikawa, Hiroshi Minamiyama, Yukiko Kadota, Mitsutaka
...
Published in
Journal of hepatology
Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species. The molecular role of CYGB in human hepatic stellate cell (HSC) activation and human liver disease remains uncharacterised. The aim of this study was to reveal the mechanism by which the TGF-β1/SMAD2 pathway regulates the human CYGB promoter and the path...
Lu, Xiao-Jie Yang, Xiao-Jun Sun, Jing-Yu Zhang, Xin Yuan, Zhao-Xin Li, Xiu-Hui
Published in
Biomarker Research
BackgroundChina is a highly endemic area of chronic hepatitis B (CHB). The accuracy of existed noninvasive biomarkers including TE, APRI and FIB-4 for staging fibrosis is not high enough in Chinese cohort.MethodsUsing liver biopsy as a gold standard, a novel noninvasive indicator was developed using laboratory tests, ultrasound measurements and liv...
Budai, Bettina Katalin Tóth, Ambrus Borsos, Petra Frank, Veronica Grace Shariati, Sonaz Fejér, Bence Folhoffer, Anikó Szalay, Ferenc Bérczi, Viktor Kaposi, Pál Novák
...
Published in
BMC Medical Imaging
BackgroundCT texture analysis (CTTA) has been successfully used to assess tissue heterogeneity in multiple diseases. The purpose of this work is to demonstrate the value of three-dimensional CTTA in the evaluation of diffuse liver disease. We aimed to develop CTTA based prediction models, which can be used for staging of fibrosis in different anato...
Yang, Fan Hu, Shenghe Sheng, Xun Liu, Yu
Published in
Biomedical Microdevices
Naringenin is highly potent dietary phenolic compound (Flavonoids) found as a major bioactive in citrus fruits. The low solubility of Naringenin, decreases its availability at the site of action by hindering solubility and transportation across the biological membrane. Naringenin loaded nanoparticles enhance the solubility and drug availability at ...
Sung, Min Je Lim, Tae Seop Jeon, Mi Young Lee, Hye Won Kim, Beom Kyung Kim, Do Young Ahn, Sang Hoon Han, Kwang-Hyub Park, Jun Yong Kim, Seung Up
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Published in
Gut and liver
Sarcopenia is associated with liver fibrosis in patients with nonalcoholic fatty liver disease and chronic hepatitis B. We investigated the association between sarcopenia and hepatic fibrotic burden in patients with type 2 diabetes mellitus (T2DM). Patients with T2DM who had received a comprehensive medical health checkup were recruited. Muscle mas...
Serag, Dena Ragab, Eman
Published in
Egyptian Journal of Radiology and Nuclear Medicine
BackgroundThere is obvious interest in finding a non-invasive diagnostic tool to detect the development of hepatic fibrosis and distinguish between its various stages. Chronic inflammation of the liver secondary to viral hepatitis, autoimmune conditions, sclerosing cholangitis, drug toxicity, chronic alcohol intake, different metabolic disorders, a...
