Ribeiro, Isabelle Tenori Fioretto, Matheus Naia Dos Santos, Sérgio Alexandre Alcantara Colombelli, Ketlin Thassiani Portela, Luiz Marcos Frediani Niz Alvarez, Marcus Vinicius de Magalhães Padilha, Pedro Delgado, Aislan Quintiliano Marques, Marcus Vinicius Lage Silva Giac... Bosqueiro, José Roberto
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Published in
Molecular and cellular endocrinology
This study investigated the impact of maternal protein restriction (MPR) and early postnatal sugar consumption (SUG) on the liver health of adult male descendant rats. Male offspring of mothers fed a normal protein diet (NPD) or a low protein diet (LPD) were divided into four groups: Control (CTR), Sugar Control (CTR + SUG), LPD during gestation an...
Guo, Qi Wei Lin, Jia Shen, Yi Lin Zheng, Yan Jiang Chen, Xu Su, Mi Zhang, Ji Cheng Wang, Jin Hua Tang, Hui Su, Guo Ming
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Published in
Molecular and cellular endocrinology
Understanding the effects of psychosocial stress on serum cholesterol may offer valuable insights into the relationship between psychological disorders and endocrine diseases. However, these effects and their underlying mechanisms have not been elucidated yet. Here we show that serum corticosterone, total cholesterol and low-density lipoprotein cho...
Hürtgen, Janine Hille, Georg Saalfeld, Sylvia Kreher, Robert Hensen, Bennet Wacker, Frank Rose, Georg Ringe, Kristina I.
Published in
Current Directions in Biomedical Engineering
Generating synthetic contrast-enhanced liver MRI scans from native MRI images can serve to mitigate the issue of sparse contrast-enhanced image datasets while concurrently circumventing the time-consuming and costly process of administering contrast agents during image acquisition. In this study, we conducted three experiments using paired image-to...
Wei, Wei Lyu, Xuchao Markhard, Andrew Fu, Sipei Mardjuki, Rachel Cavanagh, Peter Zeng, Xianfeng Rajniak, Jakub Lu, Nannan Xiao, Shuke
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Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans1-3. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from cysteine and in the downstream metabolism of secondary taurine metabolites4,5. One taurine metabolite is N-acetyltaurine6. Levels of N-acetylta...
Milton, Laura A Davern, Jordan W Hipwood, Luke Chaves, Juliana C S McGovern, Jacqui Broszczak, Daniel Hutmacher, Dietmar W Meinert, Christoph Toh, Yi-Chin
Published in
Acta biomaterialia
Decellularized extracellular matrix (dECM) hydrogels provide tissue-specific microenvironments which accommodate physiological cellular phenotypes in 3D in vitro cell cultures. However, their formation hinges on collagen fibrillogenesis, a complex process which limits regulation of physicochemical properties. Hence, achieving reproducible results w...
Benet, Leslie Z Sodhi, Jasleen K
Recently, we have proposed simple methodology to derive clearance and rate constant equations, independent of differential equations, based on Kirchhoff's Laws, a common methodology from physics used to describe rate-defining processes either in series or parallel. Our approach has been challenged in three recent publications, two published in this...
Hille, Georg Jahangir, Tameem Hürtgen, Janine Kreher, Rober Saalfeld, Sylvia
Published in
Current Directions in Biomedical Engineering
Liver vessel segmentation in computed tomography represents a highly challenging task due to the imbalanced distribution within the liver parenchyma, the small and branched vessels with decreased image contrast to surrounding tissue and in general, due to the scarcity of highresolution and -contrast images, which hampers the efficient training of d...
Ganguly, Souradipta Rosenthal, Sara Brin Ishizuka, Kei Troutman, Ty D Rohm, Theresa V Khader, Naser Aleman-Muench, German Sano, Yasuyo Archilei, Sebastiano Soroosh, Pejman
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While macrophage heterogeneity during metabolic dysfunction-associated steatohepatitis (MASH) has been described, the fate of these macrophages during MASH regression is poorly understood. Comparing macrophage heterogeneity during MASH progression vs regression, we identified specific macrophage subpopulations that are critical for MASH/fibrosis re...
L'homme, Laurent Sermikli, Benan Pelin Haas, Joel T Fleury, Sébastien Quemener, Sandrine Guinot, Valentine Barreby, Emelie Esser, Nathalie Caiazzo, Robert Verkindt, Hélène
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peer reviewed / Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism remains poorly defined. Using male mouse models of obesity and MASLD, and biopsies from carefully-characterized patients regarding obesity, type 2 diabetes (T...
Eid, Fatma-Elzahraa Chen, Albert Chan, Ken Huang, Qin Zheng, Qingxia Tobey, Isabelle Pacouret, Simon Brauer, Pamela Keyes, Casey Powell, Megan
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Broadening gene therapy applications requires manufacturable vectors that efficiently transduce target cells in humans and preclinical models. Conventional selections of adeno-associated virus (AAV) capsid libraries are inefficient at searching the vast sequence space for the small fraction of vectors possessing multiple traits essential for clinic...
