Barbălată, Cristina-Ioana Porfire, Alina Silvia Ambrus, Rita Mukhtar, Mahwash Farkas, Árpád Tomuță, Ioan
Published in
Journal of liposome research
The development of an inhalation powder (IP) for cancer therapy is desired to improve the therapeutic response and patient compliance. The latest studies highlighted that statins, a class of drugs used in hypercholesterolemia, can have anticancer and antiinflammatory properties. Therefore, the aim of the study was to develop an IP containing liposo...
mendová, katarína
As discovered through literature, a significant variability arises in the mechanical properties of living cells. This could be caused either by variability in cell mechanical properties or by differences between experimental setups. To verify the latter, we have developed a method to manufacture artificial cells for use as a reference in mechanical...
Eugster, Remo Ganguin, Aymar Abel Seidi, Amirmohammad Aleandri, Simone Luciani, Paola
Published in
Drug delivery and translational research
The peritoneal cavity offers an attractive administration route for challenging-to-treat diseases, such as peritoneal carcinomatosis, post-surgical adhesions, and peritoneal fibrosis. Achieving a uniform and prolonged drug distribution throughout the entire peritoneal space, though, is difficult due to high clearance rates, among others. To address...
Panthi, Vijay Kumar Fairfull-Smith, Kathryn E. Islam, Nazrul
Typical antibiotic treatments are often ineffectual against biofilm-related infections since bacteria residing within biofilms have developed various mechanisms to resist antibiotics. To overcome these limitations, antimicrobial-loaded liposomal nanoparticles are a promising anti-biofilm strategy as they have demonstrated improved antibiotic delive...
Ishiko, Shinya Huang, An Sun, Dong
Published in
Microvascular research
The endothelial glycocalyx (EG) undergoes early degradation in sepsis. Our recent work introduced a novel therapeutic approach involving liposomal nanocarriers of preassembled glycocalyx (LNPG) to restore EG in lipopolysaccharide (LPS)-induced sepsis model of mice. While short-term effects were promising, this study focuses on the long-term impact ...
Verma, Rajan Chowdhury, Sohini Yadav, Rajat Verma, Rajesh Prasad Shrivastava, Anurag Kumar, Mukesh Khan, Akhilesh Kumar
Published in
E3S Web of Conferences
This research investigates the cutting edge of healthcare advancement through the applications and challenges of nanomaterials focused on sedate conveyance and therapeutics. Gold nanoparticles (AuNPs) and liposomes were synthesized, characterized, and utilized as carriers for doxorubicin, illustrating remarkable medicate stacking capacities of 4.5%...
Panthi, Vijay Kumar Fairfull-Smith, Kathryn E. Islam, Nazrul
Lower respiratory tract infections (LRTIs) are inherited disorders which often causes chronic respiratory infections for which patients repeatedly receive oral antibiotics, particularly during periods of worsened lung symptoms. However, the existing treatment modalities are often unable to completely clear the responsible pathogens, which contribut...
Ying, Kejing Xin, Wanghao Xu, Yiming Lv, Dandan Zhu, Huiqi Li, Yeping Xu, Wangting Yan, Chao Li, Yiqing Cheng, Hongqiang
...
Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tumor-associated thrombus (TAT) accounts for a high proportion of venous thromboembolism. Traditional thrombolysis and anticoagulation methods are not effective due to various complications and contraindications, which can easily lead to patients dying from TAT rather than the tumor itself. These clinical issues demonstrate the need to research div...
Viera Herrera, Camila O'Connor, Paula M Ratrey, Poonam Paul Ross, R Hill, Colin Hudson, Sarah P
Published in
International journal of pharmaceutics
Thuricin CD is a two-peptide antimicrobial produced by Bacillus thuringiensis. Unlike previous antibiotics, it has shown narrow spectrum activity against Clostridioides difficile, a bacterium capable of causing infectious disease in the colon. However, peptide antibiotics have stability, solubility, and permeability problems that can affect their p...
Huang, Meigui Lu, Hui Ahmad, Mehraj Ying, Ruifeng
Published in
Food chemistry
The practical application of luteolin in food systems faces challenges due to its inherent instability. This study aimed to develop luteolin-loaded liposomes coated with whey protein isolate (WPI) to enhance the thermal stability and antioxidant activity of luteolin. The physical characteristics of both luteolin-loaded liposomes (LUT-Lips) and WPI-...
