Zhu, Ying Wang, Anni Zhang, Shuya Kim, Jisu Xia, Jiaxuan Zhang, Fengxue Wang, Dan Wang, Qi Wang, Jianxin
Published in
Journal of advanced research
Inherent or acquired resistance to paclitaxel (PTX) is a pivotal challenge for chemotherapy treatment of multidrug-resistant (MDR) breast cancer. Although various targeted drug-delivery systems, including nanoparticles and liposomes, are effective for MDR cancer treatment, their efficacy is restricted by immunosuppressive tumor microenvironment (TM...
Xu, Xiaochuang
Published in
BIO Web of Conferences
Liposomes, as biocompatible and safe nanocarriers with easily modified surfaces, can be well used in the field of antitumor. Their targeting properties have contributed to the reduction of drug dosage and non-target cell toxicity. To further exploit the targeting properties of liposomes, passive targeting liposomes, active targeting liposomes and p...
Tskitishvili, Ekaterine Palazzo, Claudio Foidart, Jean-Michel Piel, Géraldine Pequeux, Christel
peer reviewed / Estetrol (E4) is a natural estrogen synthesized only during pregnancy. It has strong neuroprotective and antioxidative activities. The aim of the present study was to define the neuroprotective potency of E4 encapsulated either in liposome (Lipo-E4) or in drug-in cyclodextrin (HP-β-CD) in liposome (DCL) system, and compare them with...
Nel, Janske Elkhoury, Kamil Velot, Émilie Bianchi, Arnaud Acherar, Samir Francius, Gregory Tamayol, Ali Grandemange, Stéphanie Arab-Tehrany, Elmira
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they are associated with critical limitations, most notably their lack of specificity resulting in systemic toxicity and the ...
Zaborova, Olga Timoshenko, Vadim Nardin, Corinne Filippov, Sergey
The mixing of conventional and pH-sensitive lipids was exploited to design novel stimuli-responsive liposomes (fliposomes) that could be used for smart drug delivery. We deeply investigated the structural properties of the fliposomes and revealed the mechanisms that are involved in a membrane transformation during a pH change. From ITC experiments ...
Krivosheeva, Olga P Doctor, Maxim A Larkina, Ekaterina A Vedenkin, Alexander S Nikolskaya, Tatiana A
Published in
Photodiagnosis and photodynamic therapy
In this work, we incorporated the hydrophobic alkylamide and hydroxyalkylamide derivatives of chlorin e6 into the lipid bilayer of liposomes. We obtained the data on the effectiveness of incorporation of studied compounds and have determined the size of liposomes and their stability when stored in liquid form. We also investigated the bioactivity o...
Chen, Xiaochen Yang, Hongying Li, Changzhu Hu, Wei Cui, Haiying Lin, Lin
Published in
Food research international (Ottawa, Ont.)
The application of plant essential oil liposomes to prevent and control food safety risks caused by Campylobacter jejuni (C. jejuni) still faces challenges such as lack of targeting and low release rate. Here, a bacteria-targeted and protease-activated antibacterial liposome (ACCLPs) was successfully synthesized through encapsulation of clove essen...
Kheoane, Poloko Stephen Enslin, Gillian Mary-Anne Tarirai, Clemence
Published in
Drug delivery and translational research
Most of the current clinically used anti-HIV and antimalarial drugs have low bioavailability, either due to poor solubility and permeability, rapid clearance from anatomical reservoirs and poor retention at their site of action (e.g. due to the p-glycoprotein efflux system), and extreme first-pass metabolism (e.g. by the cytochrome P450 enzymes). H...
Gauthy, Chloé Penoy, Noémie Evrard, Brigitte Malgrange, Brigitte Piel, Géraldine
Development of a prolonged-release form based on dexamethasone for the local treatment of neuro-sensorial hearing loss
Christensen, Gustav Urimi, Dileep Lorenzo-Soler, Laura Schipper, Nicolaas Paquet-Durand, François
Published in
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Recently, cGMP analogues have been investigated for the treatment of inherited retinal degenerations (IRD) using intravitreal injections. However, higher vitreous elimination rates limit the possibility to treat the retina with small molecule drugs. Here, we investigated the potential of lipid nanocapsules (LNCs) as vehicles to reduce clearance and...
