Silva, Maria Daniela Ray, Kaelin Gama, Miguel Remenschneider, Aaron K Sillankorva, Sanna
Published in
International journal of pharmaceutics
An increase in bacterial resistance to systemic antibiotics has sparked interest into alternative antimicrobial compounds as well as methods for effective local, non-invasive drug delivery. Topical treatments, however, may be hindered by the presence of biological barriers, such as the tympanic membrane in the case of otitis media. Herein, the tran...
Zhao, Ting Liang, Ce Zhao, Yanrong Xue, Xiangdong Ma, Zhao Qi, Jinlong Shen, Haitao Yang, Shaokun Zhang, Jia Jia, Qingzhong
...
Published in
Journal of nanobiotechnology
Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While the widely application of siRNAs in cancer treatment is severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold g...
Kurano, Takumi Kanazawa, Takanori Ooba, Aoi Masuyama, Yudai Maruhana, Nao Yamada, Mayu Iioka, Shingo Ibaraki, Hisako Kosuge, Yasuhiro Kondo, Hiromu
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
The administration of liposomes via nose-to-brain delivery is expected to become a strategy for efficient drug delivery to the central nervous system. Efficient nose-to-brain delivery and the kinetics of drugs administered in this manner depend on the properties of liposomes. However, there is a lack of basic knowledge of which liposomes are suitab...
Liu, Jinrong Ma, Chong Shi, Siwei Liu, Heng Wen, Wei Zhang, Xiuhua Wu, Zhen Wang, Shengfu
Published in
Biosensors & bioelectronics
As an important component of the COVID-19 mRNA vaccines, liposomes play a key role in the efficient protection and delivery of mRNA to cells. Herein, due to the controllable release amplification strategy of liposomes, a reliable and robust single-particle collision electrochemical (SPCE) biosensor was constructed for H9N2 avian influenza virus (H9...
Gordon, Fiona Casamayou-Boucau, Yannick Ryder, Alan G
Published in
Colloids and surfaces. B, Biointerfaces
Studying the interaction between plasma proteins and liposomes is critical, particularly for their use as drug delivery systems. Here, the efficacy of anisotropy resolved multidimensional emission spectroscopy (ARMES) for investigating the interaction of human serum albumin (HSA) with liposomes was explored and compared to conventional spectroscopi...
Krasnov, Vladimir S Kirsanov, Roman S Khailova, Ljudmila S Firsov, Alexander M Nazarov, Pavel A Tashlitsky, Vadim N Korshunova, Galina A Kotova, Elena A Antonenko, Yuri N
Published in
Bioelectrochemistry (Amsterdam, Netherlands)
A great variety of coumarin-related compounds, both natural and synthetic, being often brightly fluorescent, have shown themselves beneficial in medicine for both therapeutic and imaging purposes. Here, in search for effective uncouplers of oxidative phosphorylation, we synthesized a series of 7-hydroxycoumarin (umbelliferone, UB) derivatives combi...
Dong, Wanyi Tang, Chaoqing Xia, Minquan Sheng, Long Cai, Zhaoxia
Published in
Food chemistry
The egg yolk immunoglobulin (IgY) loaded chitosan-liposomes (IgY-CS-LP) were prepared and assisted by supercritical carbon dioxide (SCCO2). The effects of phospholipid type and SCCO2 pressure on particle size, zeta potential, encapsulation efficiency, structural properties and stabilities were investigated. The results showed that the liposomes pre...
Maruyama, Masato Tojo, Haruka Toi, Keita Ienaka, Yusuke Hyodo, Kenji Kikuchi, Hiroshi Ogawara, Ken-Ichi Higaki, Kazutaka
Published in
Journal of pharmaceutical sciences
To investigate the effect of doxorubicin (DOX) release rates from polyethylene glycol (PEG)-liposomes on the anti-tumor activity, several in-vitro and in-vivo studies were performed by utilizing three types of DOX-PEG-liposomes showing the slow (L-Slow), middle (L-Mid) and fast (L-Fast) release rates of DOX. L-Mid provided the highest anti-tumor ac...
Foreman-Ortiz, Isabel U Fung Ma, Ting Hoover, Brandon M Wu, Meng Murphy, Catherine J Murphy, Regina M Pedersen, Joel A
Published in
Journal of colloid and interface science
Nanoparticle tracking analysis (NTA) is a single particle tracking technique that in principle provides a more direct measure of particle size distribution compared to dynamic light scattering (DLS). Here, we demonstrate how statistical mixture distribution analysis can be used in combination with NTA to quantitatively characterize the amount and e...
Rani, Nur Najihah Izzati Mat Chen, Xiang Yi Al-Zubaidi, Zahraa M Azhari, Hanisah Khaitir, Tzar Mohd Nizam Ng, Pei Yuen Buang, Fhataheya Tan, Geok Chin Wong, Yin Ping Said, Mazlina Mohd
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Published in
Asian journal of pharmaceutical sciences
This study focused on the encapsulation of vancomycin (VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine, formed by conjugation of DAPT and N-hydroxysuccinimidyl-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine. This fo...