Bian, Hetao Wang, Gaohua Huang, Junjie Liang, Liang Zheng, Yage Wei, Yanyan Wang, Hui Xiao, Ling Wang, Huiling
Published in
Journal of Neuroinflammation
BackgroundRecently, depression has been identified as a prevalent and severe mental disorder. However, the mechanisms underlying the depression risk remain elusive. The neuroinflammation and NLRP3 inflammasome activation are known to be involved in the pathology of depression. Dihydrolipoic acid (DHLA) has been reported as a strong antioxidant and ...
Khanna, Sakshi Bishnoi, Mahendra Kondepudi, Kanthi Kiran Shukla, Geeta
Published in
World Journal of Microbiology and Biotechnology
Probiotics are known to modulate gut microbiota, intestinal barrier function and host immune response, but due to the species and strain specific response their mechanisms are not clearly understood. Thus, the present study was designed to isolate, assess the anti-inflammatory potential and underlying modulatory mechanisms of indigenous probiotics ...
Shrestha, Stal Kim, Min-Jeong Eldridge, Mark Lehmann, Michael L. Frankland, Michael Liow, Jeih-San Yu, Zu-Xi Cortes-Salva, Michelle Telu, Sanjay Henter, Ioline D.
...
Published in
Journal of Neuroinflammation
BackgroundCyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory prostanoids. Successful positron emission tomography (PET) radioligand imaging of COX-2 in vivo could be a potentially powerful tool for assessing inflammatory response in the b...
kim, h j joe, h i zhang, z lee, sang woo lee, k y kook, y b
We evaluated the anti-inflammatory activity of methanol extracts of Chinese medicinal plants from Beijing and determined which extract was the most effective. We found the methanol extract of Acalypha australis L. (AAL) to be the most effective. AAL has been used for clearing heat, toxic material, and hemostasia in Chinese medicine. Although these ...
Plastira, Ioanna Bernhart, Eva Joshi, Lisha Koyani, Chintan N. Strohmaier, Heimo Reicher, Helga Malle, Ernst Sattler, Wolfgang
Published in
Journal of Neuroinflammation
BackgroundIn the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. Members of the LPA family are potent lipid mediators transmitting signals via six different G protein-coupled LPA receptors (LPAR1-6). The LPA signaling axis is indispensable for brain...
Wijenayake, Sanoji Rahman, Mouly F. Lum, Christine M. W. De Vega, Wilfred C. Sasaki, Aya McGowan, Patrick O.
Published in
Journal of Neuroinflammation
BackgroundMaternal obesity as a result of high levels of saturated fat (HFD) consumption leads to significant negative health outcomes in both mother and exposed offspring. Offspring exposed to maternal HFD show sex-specific alterations in metabolic, behavioral, and endocrine function, as well as increased levels of basal neuroinflammation that per...
Seo, Young Joon Brown, Daniel
Published in
Journal of Audiology & Otology
Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere’s disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be usef...
Thomson, Carolyn A. McColl, Alison Graham, Gerard J. Cavanagh, Jonathan
Published in
Journal of Neuroinflammation
BackgroundRecent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and responds to peripheral inflammation remains poorly understood. A better understanding of these pathways may be important for generating no...
lameth, julie Arnaud-Cormos, Delia Lévêque, Philippe Boillée, Séverine Edeline, Jean-Marc Mallat, Michel
Mobile communications are propagated by electromagnetic fields (EMFs), and since the 1990s, they operate with pulse-modulated signals such as the GSM-1800 MHz. The biological effects of GSM-EMF in humans affected by neuropathological processes remain seldom investigated. In this study, a 2-h head-only exposure to GSM-1800 MHz was applied to (i) rat...
Woodcock, Eric A. Schain, Martin Cosgrove, Kelly P. Hillmer, Ansel T.
Published in
EJNMMI Research
BackgroundLipopolysaccharide (LPS) is a classic immune stimulus. LPS combined with positron emission tomography (PET) 18 kDa translocator protein (TSPO) brain imaging provides a robust human laboratory model to study neuroimmune signaling. To evaluate optimal analysis of these data, this work compared the sensitivity of six quantification approache...
