Wang, Yuli Lv, Fengyi Huang, Lintong Zhang, Hengwei Li, Bing Zhou, Weina Li, Xuan Du, Yifei Pan, Yongchu Wang, Ruixia
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Published in
Stem Cell Research & Therapy
Background and aimPeriodontitis is a chronic inflammatory disease inducing the absorption of alveolar bone and leading to tooth loss. Human amnion-derived mesenchymal stem cells (HAMSCs) have been used for studying inflammatory processes. This study aimed to explore the role of long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (...
Liu, Yaling Wang, Xiaodong Li, Peiying Zhao, Yanhua Yang, Liqun Yu, Weifeng Xie, Hong
Published in
Respiratory Research
BackgroundALI/ARDS is a severe lung injury leading to refractory respiratory failure, accounting for high morbidity and mortality. However, therapeutic approaches are rather limited. Targeting long non-coding RNA MALAT1 and microRNA miR-181a-5p might be potential option for ALI/ARDS intervention.ObjectiveWe aimed to investigate the role of MALAT an...
Aksel, Esma Gamze Akyüz, Bilal
Published in
Tropical Animal Health and Production
This is the first study investigating the changes in some gene expressions related to the TLR pathway in vivo in sheep. Lipopolysaccharide (LPS) and lipoteichoic acid (LTA) molecules were administrated separately and in combination to the Akkaraman lambs via intranasal route. For this purpose, 28 lambs were distributed into four groups (LPS, LTA, L...
Verwoolde, Michel B. Arts, Joop A.J. Lammers, Aart Jansen, Christine A.
Recently, we have reported trained innate immunity in laying chicken monocytes. In the present study, we further investigated trained innate immunity of monocytes in layers and broilers. Monocytes of both breeds isolated from blood were trained in vitro with β-glucan, rec-chicken IL-4 or a combination of both, and restimulated with lipopolysacchari...
Nomura, Masahiko Toyama, Hiroshi Suzuki, Hiromi Yamada, Takashi Hatano, Kentaro Wilson, Alan A Ito, Kengo Sawada, Makoto
Published in
Annals of nuclear medicine
The activation of microglia in various brain pathologies is accompanied by an increase in the expression of peripheral benzodiazepine receptor/18 kDa translocator protein (PBR/TSPO). However, whether activated microglia have a neuroprotective or neurotoxic effect on neurons in the brain is yet to be determined. In this study, we investigated the ab...
Jingjing, Wang Zhikai, Wu Xingyi, Zhu Peixuan, Li Yiwu, Fu Xia, Wang Youpeng, Sun Ershun, Zhou Zhengtao, Yang
Published in
International immunopharmacology
It is well-established that lysine-specific demethylase 1 (LSD1) is the first identified histone demethylase. Based on its demethylase enzymatic activity, LSD1 plays a pivotal role in vast range of cellular processes and cancers, but the understanding of its effects on inflammation is relatively limited. Using in vivo models of lipopolysaccharide (...
Lu, Zibin Cao, Huihui Liu, Dongyi Zheng, Yuanru Tian, Chunyang Liu, Shanhong Quan, Jingyu Shi, Lingzhu Liu, Junshan Yu, Linzhong
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Published in
Journal of ethnopharmacology
Liang-Ge-San (LGS), a traditional Chinese medicine (TCM) formula, is usually used in acute inflammatory diseases in China. This study aims to detect the optimal combination of anti-inflammatory components from LGS. Four mainly representative components (phillyrin, emodin, baicalin, and liquiritin) from LGS were chosen. The optimal combination was i...
Koga, Minori Toda, Hiroyuki Kinoshita, Manabu Asai, Fumiho Nagamine, Masanori Shimizu, Kunio Kobayashi, Yasushi Morimoto, Yuji Yoshino, Aihide
Published in
Progress in neuro-psychopharmacology & biological psychiatry
Although several recent studies have suggested that neuroinflammation plays a role in depression, both medication and neuroinflammatory preventive strategies have been poorly investigated. Recent studies have indicated that preconditioning with lipopolysaccharide (LPS) reduces the damage that occurs following ischemic stroke and brain trauma. Howev...
Chimenti, Laura Morales-Quinteros, Luis Puig, Ferranda Camprubi-Rimblas, Marta Guillamat-Prats, Raquel Gómez, Maria Nieves Tijero, Jessica Blanch, Lluis Matute-Bello, Gustavo Artigas, Antonio
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Published in
Intensive Care Medicine Experimental
BackgroundThe animal experimental counterpart of human acute respiratory distress syndrome (ARDS) is acute lung injury (ALI). Most models of ALI involve reproducing the clinical risk factors associated with human ARDS, such as sepsis or acid aspiration; however, none of these models fully replicates human ARDS.AimTo compare different experimental a...
Yang, Fan Yan, Jie Lu, Yuan Wang, Dengyun Liu, Li Wang, Zhengjun
Published in
Free radical research
Acute lung injury (ALI) is a life-threatening disease without effective and specific therapeutic strategies except the life-supporting treatments. Inflammation and oxidative stress are essential for the progression of ALI. MicroRNA-499-5p (miR-499-5p) has multiple pathophysiological actions; however, its function and mechanisms in ALI remain elusiv...
