Li, Chuang Wan, Weiguo Ye, Tianxin Sun, Yazhou Chen, Xiaoli Liu, Xin Shi, Shaobo Zhang, Yan Qu, Chuan Yang, Bo
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Published in
Life sciences
Recent studies have shown that, with its excellent anti-inflammatory and antioxidant effects, pinocembrin can reduce the occurrence of arrhythmia in myocardial infarction rats. However, whether it can alleviate lipopolysaccharide (LPS)-induced myocardial injury in rats has not been reported. Therefore, the purpose of this study was to investigate w...
Zheng, Aijuan Zhang, Anrong Chen, Zhimin Pirzado, Shoaib Ahmed Chang, Wenhuan Cai, Huiyi Bryden, Wayne L. Liu, Guohua
Published in
Journal of Animal Science and Biotechnology
BackgroundImmunological stress decreases feed intake, suppresses growth and induces economic losses. However, the underlying molecular mechanism remains unclear. Label-free liquid chromatography and mass spectrometry (LC-MS) proteomics techniques were employed to investigate effects of immune stress on the hepatic proteome changes of Arbor Acres br...
Peters van Ton, Annemieke M Leijte, Guus P Franssen, Gerben M Bruse, Niklas Booij, Jan Doorduin, Janine Rijpkema, Mark Kox, Matthijs Abdo, Wilson F Pickkers, Peter
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Published in
Brain, behavior, and immunity
Despite increasing evidence that immune training within the brain may affect the clinical course of neuropsychiatric diseases, data on cerebral immune tolerance are scarce. This study in healthy volunteers examined the trajectory of the immune response systemically and within the brain following repeated lipopolysaccharide (LPS) challenges. Five yo...
Wu, Yongcan Huang, Demei Wang, Xiaomin Pei, Caixia Xiao, Wei Wang, Fei Wang, Zhenxing
Published in
International immunopharmacology
Acute lung injury (ALI) is a common clinical condition with a high mortality rate and no specific treatment is available. An excessive inflammatory response contributes to the development of ALI and accelerates its progression, and the NLRP3 inflammasome and NF-κB signaling pathways are key players in inflammation. Platycodin D has been reported to...
Zamora, Ruben Chavan, Sangeeta Zanos, Theodoros Simmons, Richard L. Billiar, Timothy R. Vodovotz, Yoram
Published in
Molecular Medicine
BackgroundBacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response.MethodsUsing network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level inflammatory mediators over 0–48 h in the heart, gut, lung, liver, spleen, kidney, and systemic circulation, in ...
Shao, Changchun Yang, Xue Jing, Yingying Hou, Xiaojuan Huang, Yihua Zong, Chen Gao, Lu Liu, Wenting Jiang, Jinghua Ye, Fei
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Published in
Stem Cell Research & Therapy
BackgroundThe liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has not been elucidated. Here, we hypothesized that high levels of lipopolysaccharide from the portal vein might maintain the stemness o...
Witte, Sander Zinsli, Léa V. Gonzalez-Serrano, Rafael Matter, Cassandra I. Loessner, Martin J. van Mierlo, Joël T. Dunne, Matthew
Published in
Computational and Structural Biotechnology Journal
Bacteriophages (phages) are widely used as biocontrol agents in food and as antibacterial agents for treatment of food production plant surfaces. An important feature of such phages is broad infectivity towards a given pathogenic species. Phages attach to the surfaces of bacterial cells using receptor binding proteins (RBPs), namely tail fibers or ...
Moludi, Jalal Kafil, Hossein Samadi Qaisar, Shaimaa A. Gholizadeh, Pourya Alizadeh, Mohammad Vayghyan, Hamed Jafari
Published in
Nutrition Journal
PurposeAlterations in the gut microbiome (dysbiosis) has been associated with increased microbial translocation, leading to chronic inflammation in coronary artery disease (CAD). It has been proposed that modulation of gut microbiota by probiotic might modify metabolic endotoxemia. Therefore, the purpose of this study was to examine the effects of ...
Yan, Chenbo Lv, Haimiao Peng, Zhan Yang, Dexin Shen, Puxiu Yu, Jingcheng Tong, Chao Wang, Xinzhuang
Published in
Theriogenology
After parturition, bovine uterine stromal cells are often exposed to complex bacterial and viral stimuli owing to epithelial cell rupture, resulting in an inflammatory response. In this study, we used an in vitro model to study the response of bovine endometrial stromal cells to inflammatory mediators and the associated regulated microRNAs in respo...
Kumar, Mohit Arora, Palkin Sandhir, Rajat
Published in
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Activation of microglia is a hallmark of neuroinflammation and has been implicated in the development of many psychiatric disorders. Hydrogen sulfide (H2S); a gasotransmitter has recently emerged as a potent antioxidant and anti-inflammatory molecule. However, the protective potential of H2S and its underpin molecular mechanisms in neuroinflammatio...
