Xing, Guanlan Li, Jinyu Li, Wenli Lam, Sin Man Yuan, Hongli Shui, Guanghou Yang, Jinshui
Published in
Biotechnology for Biofuels
BackgroundBoth APETALA2/Ethylene Responsive Factor (AP2/ERF) superfamily and R2R3-MYB family were from one of the largest diverse families of transcription factors (TFs) in plants, and played important roles in plant development and responses to various stresses. However, no systematic analysis of these TFs had been conducted in the green algae A. ...
Cabré, Noemí Gil, Míriam Amigó, Núria Luciano-Mateo, Fedra Baiges-Gaya, Gerard Fernández-Arroyo, Salvador Rodríguez-Tomàs, Elisabet Hernández-Aguilera, Anna Castañé, Helena París, Marta
...
Published in
Scientific Reports
Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we in...
Morillon, Aude-Claire Leite, Debora F. B. Yakkundi, Shirish Gethings, Lee A Thomas, Gregoire Baker, Philip N. Kenny, Louise C. English, Jane A. McCarthy, Fergus P.
Published in
Metabolomics
IntroductionSmall for gestational age (SGA) may be associated with neonatal morbidity and mortality. Our understanding of the molecular pathways implicated is poor.ObjectivesOur aim was to determine the metabolic pathways involved in the pathophysiology of SGA and examine their variation between maternal biofluid samples.MethodsPlasma (Cork) and ur...
Pannkuk, Evan L. Laiakis, Evagelia C. Mak, Tytus D. Astarita, Giuseppe Authier, Simon Wong, Karen Fornace, Albert J. Jr.
Published in
Metabolomics
IntroductionDue to dangers associated with potential accidents from nuclear energy and terrorist threats, there is a need for high-throughput biodosimetry to rapidly assess individual doses of radiation exposure. Lipidomics and metabolomics are becoming common tools for determining global signatures after disease or other physical insult and provid...
Wang, Jie Liao, Jie Wang, Honghai Zhu, Xiaofang Li, Linqiu Lu, Weibo Song, Gongshuai Shen, Qing
Published in
Food chemistry
Shellfishes contain plasmalogens correlating to the functions of brain, heart, etc. Herein, a mild acid hydrolysis and hydrophilic interaction chromatography (HILIC) tandem mass spectrometry method was developed for analyzing plasmalogens in six shellfish species. A total of 19 plasmalogen molecular species were successfully identified, including n...
Sobczak, Amélie I.S. Pitt, Samantha J. Smith, Terry K. Ajjan, Ramzi A. Stewart, Alan J.
Published in
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
• Plasma concentrations of major FFA species are lower in T1DM compared to controls. • Plasma FFA concentrations negatively correlates with HbA1c in T1DM. • The SCD1 index is reduced in T1DM. • Lipogenesis, elongase, n3/n6, saturated/unsaturated indices are increased in T1DM. • Collectively, the data highlight specific changes in lipid metabolism i...
De Sabato, Luca Di Bartolo, Ilaria De Marco, Maria Alessandra Moreno, Ana Lelli, Davide Cotti, Claudia Delogu, Mauro Vaccari, Gabriele
Published in
Viruses
Due to their need for living cells, viruses have developed adaptive evolutionary strategies to survive and perpetuate in reservoir hosts that play a crucial role in the ecology of emerging pathogens. Pathogenic and potentially pandemic betacoronaviruses arose in humans in 2002 (SARS-CoV, disappeared in July 2003), 2012 (MERS-CoV, still circulating ...
Jiang, Yiming Yao, Xinpeng Fan, Shicheng Gao, Yue Zhang, Huizhen Huang, Min Bi, Huichang
Published in
Journal of pharmaceutical and biomedical analysis
Pregnane X receptor (PXR) is highly expressed in the liver and plays an integral role in the control of xenobiotic and endobiotic metabolism to maintain homeostasis. We previously reported that activation of PXR significantly induced liver enlargement. But the lipid profiling during PXR-induced hepatomegaly remains unclear. This study aimed to char...
Zoong Lwe, Zolian S. Welti, Ruth Anco, Daniel Naveed, Salman Rustgi, Sachin Narayanan, Sruthi
Published in
Scientific Reports
Understanding the changes in peanut (Arachis hypogaea L.) anther lipidome under heat stress (HT) will aid in understanding the mechanisms of heat tolerance. We profiled the anther lipidome of seven genotypes exposed to ambient temperature (AT) or HT during flowering. Under AT and HT, the lipidome was dominated by phosphatidylcholine (PC), phosphati...
Dos Santos, Ancély F. Inague, Alex Arini, Gabriel S. Terra, Letícia F. Wailemann, Rosangela A. M. Pimentel, André C. Yoshinaga, Marcos Y. Silva, Ricardo R. Severino, Divinomar de Almeida, Daria Raquel Q.
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Published in
Cell Death & Disease
Lack of effective treatments for aggressive breast cancer is still a major global health problem. We have previously reported that photodynamic therapy using methylene blue as photosensitizer (MB-PDT) massively kills metastatic human breast cancer, marginally affecting healthy cells. In this study, we aimed to unveil the molecular mechanisms behind...
