Large spiders don't stop under pressure
Deep ocean metagenomes provide insight into the metabolic architecture of bathypelagic microbial communities
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The deep sea, the largest ocean's compartment, drives planetary-scale biogeochemical cycling. Yet, the functional exploration of its microbial communities lags far behind other environments. Here we analyze 58 metagenomes from tropical and subtropical deep oceans to generate the Malaspina Gene Database. Free-living or particle-attached lifestyles d...
Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane
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Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) by selectively targeting lipopolysaccharide (LPS), it was unclear how this led to bacterial killing. We discovered that MCR-1 mediated colistin resistance in Esch...
Semiparametric estimation of the nonmixture cure model with auxiliary survival information
With rapidly increasing data sources, statistical methods that make use of external information are gradually becoming popular tools in medical research. In this article, we efficiently synthesize the auxiliary survival information and propose a semiparametric estimation method for the combined empirical likelihood in the framework of the nonmixtur...
Evolutionary simulations clarify and reconcile biodiversity-disturbance models
There is significant geographic variation in species richness. However, the nature of the underlying relationships, such as that between species richness and environmental stability, remains unclear. The stability-time hypothesis suggests that environmental instability reduces species richness by suppressing speciation and increasing extinction ris...
ALZHEIMER'S DISEASE Exploring the origins of nucleation
An approach called deep mutational scanning is improving our understanding of amyloid beta aggregation. / status: published
Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight...
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From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in di...
mmsig: a fitting approach to accurately identify somatic mutational signatures in hematological malignancies
Mutational signatures have emerged as powerful biomarkers in cancer patients, with prognostic and therapeutic implications. Wider clinical utility requires access to reproducible algorithms, which allow characterization of mutational signatures in a given tumor sample. Here, we show how mutational signature fitting can be applied to hematological c...
A generic approach to study the kinetics of liquid-liquid phase separation under near-native conditions (vol 4, 77, 2021...
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status: published
Tool-shaped ladybird hairs guarded by protein
