Smolders, Stefanie Philtjens, Stéphanie Crosiers, David Sieben, Anne Hens, Elisabeth Heeman, Bavo Van Mossevelde, Sara Pals, Philippe Asselbergh, Bob Dos Santos Dias, Roberto
...
Published in
Acta Neuropathologica Communications
Dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) are clinically, pathologically and etiologically disorders embedded in the Lewy body disease (LBD) continuum, characterized by neuronal α-synuclein pathology. Rare homozygous and compound heterozygous premature termination codon (PTC) mutations in the Vacuolar Protein Sorting 13 homolog C...
Attems, Johannes Toledo, Jon B Walker, Lauren Gelpi, Ellen Gentleman, Steve Halliday, Glenda Hortobagyi, Tibor Jellinger, Kurt Kovacs, Gabor G Lee, Edward B
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Published in
Acta neuropathologica
Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleag...
Attems, Johannes Toledo, Jon B Walker, Lauren Gelpi, Ellen Gentleman, Steve Halliday, Glenda Hortobagyi, Tibor Jellinger, Kurt Kovacs, Gabor G Lee, Edward B
...
Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleag...
Fenyi, Alexis Duyckaerts, Charles Bousset, Luc Braak, Heiko Tredici, Kelly Del Melki, Ronald on behalf of the Brainbank Neuro-CEB Neu...
Published in
Cells
We investigated α-synuclein’s (αSyn) seeding activity in tissue from the brain and enteric nervous system. Specifically, we assessed the seeding propensity of pathogenic αSyn in formalin-fixed tissue from the gastric cardia and five brain regions of 29 individuals (12 Parkinson’s disease, 8 incidental Lewy body disease, 9 controls) using a protein ...
Attems, Johannes; Toledo, Jon B; Walker, Lauren; Gelpi, Ellen; Gentleman, Steve; Halliday, Glenda; Hortobagyi, Tibor; Jellinger, Kurt; Kovacs, Gabor G; Lee, Edward B;
...
Currently, the neuropathological diagnosis of Lewy body disease (LBD) may be stated according to several staging systems, which include the Braak Lewy body stages (Braak), the consensus criteria by McKeith and colleagues (McKeith), the modified McKeith system by Leverenz and colleagues (Leverenz), and the Unified Staging System by Beach and colleag...
Tanei, Zen-ichi Saito, Yuko Ito, Shinji Matsubara, Tomoyasu Motoda, Atsuko Yamazaki, Mikihiro Sakashita, Yasuhiro Kawakami, Ito Ikemura, Masako Tanaka, Shinya
...
Published in
Acta Neuropathologica
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson’s disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by no...
Strickland, Samantha L. Morel, Hélène Prusinski, Christian Allen, Mariet Patel, Tulsi A. Carrasquillo, Minerva M. Conway, Olivia J. Lincoln, Sarah J. Reddy, Joseph S. Nguyen, Thuy
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Published in
Acta Neuropathologica Communications
Missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are few studies of these variants in purely neuropathologically diagnosed cohorts. Further, the effect of these muta...
Ford, Andrew Almeida, Osvaldo P
Published in
International journal of geriatric psychiatry
Parkinson disease and dementia with Lewy bodies (collectively termed Lewy body disease) are common neurodegenerative conditions of later life and are frequently associated with distressing psychotic symptoms. The best approach to manage these symptoms is yet to be established and current treatments carry the risk of serious adverse effects. We perf...
Papuć, Ewa
Published in
Current Problems of Psychiatry
Introduction: Introduction: Both dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are important dementia syndromes that overlap in their clinical features and clinical course, neuropathological abnormalities, and also therapeutic approach. Nevertheless it is still unclear whether DLB and PDD are two different disorders that re...
Manabe, Yuta
Published in
Frontiers in Nutrition
Background: Clonazepam (CNZP) is effective in ~90% of patients with rapid eye movement sleep behavior disorder (RBD) but has risks of oversedation, muscular relaxation, and adverse effects on cognitive function when used to treat RBD associated with dementia with Lewy bodies (DLB). Yokukansankachimpihange (YKSCH), a traditional herbal medicine, dec...
