Sharma, Sunita Gaur, Kavita Perme, Tatton Singh, Amrita
Published in
Fetal and pediatric pathology
Background: B-cell acute lymphoblastic leukemia is known for heterogeneous blast morphology. Cytoplasmic granules and blebs have both been described, but not together, in lymphoblasts. Case presentation: A 7-year-old boy presented with fever, abdominal distension for 3 weeks, with hepatosplenomegaly. Investigations revealed pancytopenia, peripheral...
Mustafa, Al-Hassan M Ashry, Ramy Krämer, Oliver H
Published in
Methods in molecular biology (Clifton, N.J.)
Reactive oxygen species (ROS) are induced by several chemotherapeutics. In this protocol, we describe a flow cytometry-based method for the analysis of the intracellular levels of ROS in vital leukemic cells in response to the histone deacetylase inhibitor vorinostat. This measurement of ROS using the cell-permeable dye CM-H2DCFDA indicates intrace...
Pons, Miriam Beyer, Mandy
Published in
Methods in molecular biology (Clifton, N.J.)
One of the main characteristics of cancer is the rapid proliferation of transformed cells. Cancer therapies aim to kill such cells. Cancer clones surviving therapy can be resistant to the treatment, but they can also lose the ability to proliferate. The ability of single cells to proliferate can be monitored in vitro and can provide insights into t...
Dunphy, Katie Dowling, Paul
Published in
Methods in molecular biology (Clifton, N.J.)
Cancer of blood or bone marrow-derived cells dysregulates normal hematopoiesis and accounts for over 6% of all cancer cases annually. Proteomic analyses of blood cancers have improved our understanding of disease mechanisms and identified numerous proteins of clinical relevance. For many years, gel-based proteomic studies have aided in the discover...
Verdezoto Unda, Stella Damaris Estrella, Bertha Robles Aguirre, Renato Samuel
Acute lymphoblastic leukemia is the most common childhood neoplasia. Current treatments allow more than 80% disease-free survival for five years. In 2000, a chemotherapy protocol called Berlin-Frankfurt-Münster intercontinental lymphoblastic leukemia (ALLIC BFM) was tested. The investigative process was carried out using the PRISMA methodology. Thi...
van Eijs, Mick J M van der Wagen, Lotte E Mous, Rogier Leguit, Roos J van de Corput, Lisette van Lindert, Anne S R Suelmann, Britt B M Kamphuis, Anna M Nierkens, Stefan Suijkerbuijk, Karijn P M
...
Published in
Cancer immunology, immunotherapy : CII
Immune checkpoint inhibition (ICI) can induce durable responses in patients with advanced malignancies. Three cases of hematological neoplasia following ICI for solid tumors have been reported to date. We present five patients treated at our tertiary referral center between 2017 and 2021 who developed chronic myeloid leukemia (two patients), acute ...
Haase, Christa Richter, Dmitry Lin, Charles P
Published in
Methods in molecular biology (Clifton, N.J.)
The bone marrow (BM) has traditionally been a difficult tissue to access because it is embedded deep within the bone matrix. It is home to the hematopoietic stem cells (HSCs) that give rise to all blood cells in the body. It is also the site of origin for malignant blood cells such as leukemia and multiple myeloma, as well as a frequent site of met...
Xu, Suzanne Singh, Katelyn McNiff, Jennifer Damsky, William Gehlhausen, Jeffrey R
Published in
JAAD case reports
Anand, Sonia T Ryckman, Kelli K Baer, Rebecca J Charlton, Mary E Breheny, Patrick J Terry, William W Kober, Kord Oltman, Scott Rogers, Elizabeth E Jelliffe-Pawlowski, Laura L
...
Published in
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Leukemia and lymphoma are cancers affecting children, adolescents, and young adults and may affect reproductive outcomes and maternal metabolism. We evaluated for metabolic changes in newborns of mothers with a history of these cancers. A cross-sectional study was conducted on California births from 2007 to 2011 with linked maternal hospital discha...
Mao, Ping Huang, Changhao Li, Yuyu Zhao, Yuanyi Zhou, Sujin Zhao, Zhenggang Mu, Yunping Wang, Lina Li, Fanghong Zhao, Allan Z
...
Published in
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Acute myeloid leukemia (AML) is prone to drug-resistant relapse with a low 5-year survival rate. New therapeutic modalities are sorely needed to provide hope for AML relapse patients. Herein, we demonstrated a specific inhibitor of type 4 phosphodiesterase (PDE4), Zl-n-91, could significantly reduce the proliferation of AML cells, block DNA replica...
