Desterke, Christophe Bennaceur-Griscelli, Annelise Turhan, Ali G.
Published in
Stem Cell Research & Therapy
BackgroundDuring aging, hematopoietic stem cells (HSC) lose progressively both their self-renewal and differentiation potential. The precise molecular mechanisms of this phenomenon are not well established. To uncover the molecular events underlying this event, we have performed a bioinformatics analysis of 650 single-cell transcriptomes.MethodsSin...
Busch, Robert
Published in
Frontiers for Young Minds
B cells are small white blood cells that contribute to our immune defenses. They produce antibodies, which help us to recover from infections. B cells may cause diseases when they misbehave. If they mutate and then divide out of control, B cells can produce blood cancers called leukemias or tissue cancers called lymphomas. This article traces the d...
Xu, Binyan Hu, Rong Liang, Zhao Chen, Tong Chen, Jianyu Hu, Yuxing Jiang, Yirong Li, Yuhua
Published in
Blood reviews
Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow microenvironment through metabolis...
Mitchell, Shaneice Zhang, Pu Cannon, Matthew Beaver, Larry Lehman, Amy Harrington, Bonnie Sampath, Deepa Byrd, John C. Lapalombella, Rosa
Published in
Journal of Hematology & Oncology
KPT-9274 is a phase 1 first-in-class dual PAK4/NAMPT inhibitor for solid tumor and non-Hodgkin’s lymphoma. It demonstrates pre-clinical efficacy toward a broad spectrum of acute myeloid leukemia (AML) subtypes by inhibiting NAMPT-dependent NAD+ production. NAMPT is the rate-limiting enzyme in the salvage metabolic pathway leading to NAD+ generation...
Govaerts, Inge Prieto, Cristina Vandersmissen, Charlien Gielen, Olga Jacobs, Kris Provost, Sarah Nittner, David Maertens, Johan Boeckx, Nancy De Keersmaecker, Kim
...
Published in
Journal of Hematology & Oncology
BackgroundT cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype that comprises 10–15% of childhood and 20–25% of adult ALL cases. Over 70% of T-ALL patients harbor activating mutations in the NOTCH1 signaling pathway and are predicted to be sensitive to gamma-secretase inhibitors. We have recently demonstrated that selective inhibition...
Shariati, Aref Didehdar, Mojtaba Rajaeih, Shahin Moradabadi, Alireza Ghorbani, Mohammad Falahati, Vahid Chegini, Zahra
Published in
Annals of Clinical Microbiology and Antimicrobials
BackgroundAspergillosis of Central Nervous System (CNS) is a highly lethal infection in patients with leukemia and Stem Cell Transplantation (SCT).MethodsCase reports of CNS aspergillosis in patients with leukemia and SCT published between 1990 and August 2020 were gathered using a structured search through PubMed/Medline.ResultsSixty-seven cases w...
Marison, Scott R. Jr Pati, Brooke Laferriere, Nicole R. Woo, Russell K. Ha, Ally
Published in
International Journal of Surgery Case Reports
• Acute appendicitis is a rare initial manifestation of hematologic malignancy. • Histopathological evaluation of surgical specimens is essential in patient care. • Atypical presentations of acute appendicitis can lead to a delay in diagnosis. • Signs of acute appendicitis may be masked in neutropenic patients.
Harris, Katherine LaBelle, James L. Bishop, Michael R.
Published in
Current Treatment Options in Oncology
Chimeric antigen receptor (CAR) T-cell therapy has become the standard of care for children and young adults with relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL), and it is a highly promising therapy under investigation for adults with relapsed disease. Despite having potentially life-threatening toxicities, such as cytokine rel...
Bellon, Marcia Bialuk, Izabela Galli, Veronica Bai, Xue-Tao Farre, Lourdes Bittencourt, Achilea Marçais, Ambroise Petrus, Michael N. Ratner, Lee Waldmann, Thomas A.
...
Published in
Molecular Cancer
BackgroundHuman T cell Leukemia virus type 1 (HTLV-I) is etiologically linked to adult T cell leukemia/lymphoma (ATL) and an inflammatory neurodegenerative disease called HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP). The exact genetic or epigenetic events and/or environmental factors that influence the development of ATL, ...
Mairuhu, Anitha Marllyin Andarsini, Mia Ratwita Setyoningrum, Retno Asih Cahyadi, Andi Larasati, Maria Christina Shanty Ugrasena, I.Dewa Gede Permono, Bambang Budiman, Satrio
Published in
Heliyon
Hospital-acquired pneumonia, Acute lymphoblastic leukemia, Chemotherapy, Neutropenia, Leukemia, Pneumonia.
