Iranian Biomedical Journal
Background: To study the anticancer activity of Plantago major , we assessed the effect of ethanolic, methanolic and acetonic extracts of this plant on HCT-116, SW-480, and HEK-293 cell lines as control. Methods: The cytotoxic activity , biocompatibility, and toxicity were evaluated by MTT assay, hemolysis, and Artemia salina -LD50 (on mice) tests,...
Journal of menopausal medicine
This review paper evaluates use of Foeniculum vulgare extracts as a popular female plant in management of different ailments of women. Information in this paper was gathered from accessible sources (PubMed, Science Direct, Springer, Wiley, and Google), and traditional books (Persian or English modern traditional books), unpublished data (R&D report...
Journal of Medical Case Reports
BackgroundAlthough 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported.Case presentationAn 18-year-old Japanese woman who had taken an overdose of prescription colchicine (15 mg; 0.2 mg/kg) was brought to our emergency out-patie...
Materials science & engineering. C, Materials for biological applications
Poly(maleic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro [5.5] undecane), acquired through radical polymerization, was synthesized with the aim to prepare an alternant copolymer with precise placement of functional groups along the polymer backbones. The new structure owing to the suitable and specific functionalities is anticipated to be used a...
Safety and health at work
When injected repeatedly for 13 weeks, methylcyclohexane proved to be toxic for the liver, heart, and kidney at a high dose. The absolute toxic dose was 1,000 mg/kg/day, while the no observed adverse effect level was less than 100 mg/kg/day. The substance exerted little influence on the reproductive system.
Studies in Natural Products Chemistry
Pharmacological properties of S. sclarea and S. desoleana oils are discussed in relation to their chemical composition. After systemic administration, these oils had a depressant action on the CNS in mice and a hydrocholeretic effect in rats. Otherstudies demonstrated also a good anti-inflammatory activity in rats as well as a peripheral analgesic ...