Duthie, Malcolm S. Reed, Steven G.
Published in
Applied Microbiology and Biotechnology
Abstract Immunological and molecular advances have modernized diagnostic testing for many diseases. Although interferon gamma-release and polymerase chain reaction assays have been developed to detect Mycobacterium tuberculosis (Mtb) infection, purified protein derivative (PPD)–based tuberculin skin testing (TST) remains the most widely used method...
McMahon, Devon E Oyesiku, Linda Semeere, Aggrey Kang, Dongkyun Freeman, Esther E
Published in
Dermatologic clinics
In resource-limited settings, point-of-care diagnostic devices have the potential to reduce diagnostic delays and improve epidemiologic surveillance of dermatologic conditions. We outline novel-point-of care diagnostics that have recently been developed for dermatologic conditions that primarily affect patients living in resource-limited settings, ...
Chae, Gue-Tae
Published in
Infection & Chemotherapy
Modern history of Hansen's Disease (HD) in Korea begins with nationwide use of the chemotherapeutic agent Diamino Diphenyl Sulphone for the patients in 1955. Definition of the case was different from time to time. Based on World Health Organization (WHO) criteria, Ministry of Health and Welfare (MOHW) reported 4,393 registered patients and same num...
Marçal, Pedro Henrique Ferreira Gama, Rafael Silva Pereira de Oliveira, Lorena Bruna Martins-Filho, Olindo Assis Pinheiro, Roberta Olmo Sarno, Euzenir Nunes Moraes, Milton Ozório de Oliveira Fraga, Lucia Alves
Published in
Infectious Diseases of Poverty
BackgroundLeprosy is a chronic infectious disease classified into two subgroups for therapeutic purposes: paucibacillary (PB) and multibacillary (MB), closely related to the host immune responses. In this context it is noteworthy looking for immunological biomarkers applicable as complementary diagnostic tools as well as a laboratorial strategy to ...
Kerudin, Ammielle
The overall aim of this study was to employ a biomolecular technique â ancient DNA (aDNA) â to study two ancient diseases that were endemic in Europe (and therefore Britain) during the medieval period: tuberculosis and leprosy. In humans, the diseases are caused by M. tuberculosis and M. leprae, respectively â both of which are members of the...
Neves, Karine Vila Real Nunes Nobre, Maurício Lisboa Machado, Lúbia Maieles Gomes Steinmann, Peter Ignotti, Eliane
Published in
Acta tropica
Leprosy causes a range of symptoms, and most diagnoses are established based on the clinical picture. Therefore, false negative and positive diagnoses are relatively common. We analyzed the spatial pattern of leprosy misdiagnosis and associated factors in Brazil. Exploratory analyses of Kernel density of the new case detection rate (NCDR) and propo...
Souza, Carlos Dornels Freire de Paiva, João Paulo Silva de Leal, Thiago Cavalcanti Urashima, Gabriel da Silva
Abstract The objective of this study was to analyze the trend of epidemiological and operational indicators of leprosy in Brazil, from 2001 to 2017. This was a time series study involving nine indicators. The inflection point regression model was used. Decreasing trends were observed for the following: general detection (−4.8%), children under 15 (...
Rodrigues, Thaísa S.V. Gomes, Luciane C. Cortela, Denise C.B. Silva, Eliane A. Silva, Cristiane A.L. Ferreira, Silvana M.B.
Abstract Objectives: To analyze the factors associated with leprosy in children who were intradomiciliary contacts of notified adults with the disease in an endemic municipality in Mato Grosso, Brazil. Method: Case-control study with 204 children under 15 years of age, living in an endemic municipality. Cases (n = 40) were considered as the childre...
Barbosa, Celivane Cavalcanti do Bonfim, Cristine Vieira de Brito, Cintia Michele Gondim de Souza, Wayner Vieira Melo, Marcella Fernandes de Oliveira de Medeiros, Zulma Maria
Published in
Revista do Instituto de Medicina Tropical de São Paulo
Leprosy is a public health problem due to the physical disabilities and deformities it causes. This study aimed to describe new leprosy cases using an operational classification and analyzing spatial patterns by means of epidemiological and quality indicators of health services in Pernambuco State, Brazil, between 2005 and 2014. This was an ecologi...
Ribeiro, Afonso Bezerra Caloi, Caroline Marques Pimenta, Silvia Thais Sá Seshayyan, Sudha Govindarajulu, Srinivas Souto, Francisco José Dutra Damazo, Amílcar Sabino
Published in
Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION In leprosy, immune system mediators that regulate the infectious process act in a complex manner and can lead to several clinical outcomes. To understand the behavior of these mediators we quantified the expression of annexin-A1 (ANXA1) in the peripheral blood and plasma as well as tissue leukocytes in all clinical forms of leprosy and...
