de Oliveira Leite, Gerlânia Santos, Sacha Aubrey Alves Rodrigues Bezerra, Francisca Magnólia Diógenes Hol... Sena E Silva, Francisco Evilyn de Castro Ribeiro, Antonia Deyse Roma, Renato Rodrigues Silva, Romério Rodrigues Santos Santos, Maria Helena Cruz Santos, Ana Lucia Estevam Teixeira, Claudener Souza
...
Published in
International journal of biological macromolecules
Lectins are proteins of non-immunological origin that may play several biological applications, of which we can highlight the anti-inflammatory and antinociceptive activities. In this work, we evaluated the possible effect of orofacial antinociceptive activity of three plant lectins, Dioclea violacea (DVL - Man/Glc-binding), Vatairea macrocarpa (VM...
Martínez-Ocaña, Joel Maravilla, Pablo Olivo-Díaz, Angélica
Published in
Revista do Instituto de Medicina Tropical de São Paulo
Intestinal mucins are the first line of defense against microorganisms. Although knowledge about the mechanisms involved in the establishment of intestinal protozoa is limited, there is evidence that these parasites produce lectin-like molecules and glycosidases, that exert both, constitutive and secretory functions, promoting the establishment of ...
Sohrab, Sayed Sartaj Suhail, Mohd Kamal, Mohammad Amjad Ahmad, Fahim Azhar, Esam Ibraheem
Published in
Current pharmaceutical design
Human coronaviruses (HCoV) are common viruses and known to be associated with respiratory diseases, including pneumonia. Currently, there are seven human coronaviruses have been identified and known to cause upper and lower respiratory infections as well as nosocomial viral infections in human. The bats, palm civets and camels are identified as the...
He, Na Jiang, Ying Lei, Lingli Liu, Yingshuai
Published in
Analytical biochemistry
In this work, we report a novel cell surface glycan analysis method based on persistent luminescence nanoparticle (PLNP) ZnGa2O4: Cr3+ (ZGC) as an optical probe. ZGC was first silanized by (3-Aminopropyl) triethoxysilane (APTES), followed by PEGylation with NHS-P EG-Biotin, which not only introduces biotin, but significantly improves the dispersibi...
El-Araby, Magda M. El-Shatoury, Einas H. Soliman, Mervat M. Shaaban, Hanan F.
Published in
AMB Express
Lectins are carbohydrate-binding proteins that play vital roles in many biological processes. In this study, lectins from three Egyptian cultivars (fava bean, lentil, and pea) were isolated by precipitation with different concentrations of ammonium sulfate. The purification process was performed by affinity chromatography using mannose agarose. The...
Järvå, Michael A. Lingford, James P. John, Alan Soler, Niccolay Madiedo Scott, Nichollas E. Goddard-Borger, Ethan D.
Published in
Nature Communications
Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.
Shastry, Divya G. Irudayanathan, Flaviyan Jerome Williams, Asher Koffas, Mattheos Linhardt, Robert J. Nangia, Shikha Karande, Pankaj
Published in
Scientific Reports
The alpha-2,8-linked form of the polysaccharide polysialic acid (PSA) has widespread implications in physiological and pathological processes, ranging from neurological development to disease progression. Though the high electronegativity and excluded volume of PSA often promotes interference of biomolecular interactions, PSA-binding ligands have i...
Kuhaudomlarp, Sakonwan Gillon, Émilie Varrot, Annabelle Imberty, Anne
LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. The lectin is specific for α-galactose present on glycosphingolipids of the globoside family and has therefore been proposed to play a role in cell adhesion and in internalization of bacteria in epithelial cells. The lectin has also direct toxic a...
Matsuoka, Koji Suzuki, Yuya Koyama, Tetsuo Matsushita, Takahiko Hatano, Ken
Published in
Bioorganic & medicinal chemistry letters
A convenient assembly of fluorogenic glycopolymers having various polymer compositions was accomplished from the corresponding glycomonomer and dansyl monomer by means of radical polymerization, and the water-soluble glycopolymers gave typical fluorescence spectroscopic profiles due to the dansyl moieties on the glycopolymer in aqueous media. Biolo...
Chiu, Yi-Ping Sun, Yung-Chen Qiu, De-Chen Lin, Yu-Hao Chen, Yin-Quan Kuo, Jean-Cheng Huang, Jie-rong
Published in
Nature Communications
Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that the galectin-3 NTD undergoes liquid-liquid phase sep...
