dos Santos, Ardilles Juan Carlos Alves da Silva Barros, Bárbara Rafaela de Souza Aguiar, Lethícia Maria de Siqueira Patriota, Leydianne Leite de Albuquerque Lima, Thâmarah Zingali, Russolina Benedeta Paiva, Patrícia Maria Guedes Napoleão, Thiago Henrique de Melo, Cristiane Moutinho Lagos Pontual, Emmanuel Viana
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Published in
3 Biotech
Schinus terebinthifolia leaf lectin (SteLL) was reported to be an antimicrobial and antitumor agent. In this work, we evaluated the immunomodulatory activity of SteLL on mice splenocytes and also determined its native molecular mass and putative sequence similarities with plant proteins. The effects of SteLL (12.5 μg/mL) on viability, cytosolic Ca2...
Cavada, Benildo Sousa Osterne, Vinicius Jose Silva Pinto-Junior, Vanir Reis Souza, Luiz Augusto Gomez Lossio, Claudia Figueiredo Silva, Mayara Torquato Lima Correia-Neto, Corneville Oliveira, Messias Vital Correia, Jorge Luis Almeida Neco, Antonio Hadson Bastos
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Published in
Journal of Molecular Modeling
The Tn antigen is an epitope containing N-acetyl-D-galactosamine present in the extracellular matrix of some carcinoma cells in humans, and it is often used as a biomarker. Lectins are proteins capable of binding to carbohydrates and can be used as a molecular tool to recognize antigens and to differentiate cancer cells from normal cells. In this c...
Madaoui, Mimouna
La hausse du phénomène de multirésistance aux antibiotiques compte parmi les problèmes de santé publique majeur du XXIème siècle. Pseudomonas aeruginosa (PA) est classé dans le top cinq des bactéries les plus virulentes. Plusieurs stratégies ont été développées afin de combattre ces infections, parmi elles nous nous sommes intéressés à l'utilisatio...
Sýkorová, Petra Novotná, Jitka Demo, Gabriel Pompidor, Guillaume Dubská, Eva Komárek, Jan Fujdiarová, Eva Houser, Josef Hároníková, Lucia Varrot, Annabelle
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Published in
International journal of biological macromolecules
Burkholderia pseudomallei and Chromobacterium violaceum are bacteria of tropical and subtropical soil and water that occasionally cause fatal infections in humans and animals. Microbial lectins mediate the adhesion of organisms to host cells, which is the first phase in the development of infection. Here we report the discovery of two novel lectins...
Silva, Romerio R S Silva, Carolina R Santos, Valdenice F Barbosa, Cristina R S Muniz, Debora F Santos, Ana L E Santos, Maria H C Rocha, Bruno A M Batista, Karla L R Costa-Júnior, Livio M
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Published in
Microbial pathogenesis
Lectins have been studied in the past few years as an alternative to inhibit the development of pathogenic bacteria and gastrointestinal nematodes of small ruminants. The development of new antibacterial and anthelmintic compounds is necessary owing to the increase in drug resistance among important pathogens. Therefore, this study aimed to evaluat...
Almand, Erin A. Moore, Matthew D. Jaykus, Lee-Ann
Published in
BMC Research Notes
ObjectiveResearch suggests human norovirus binding to histo-blood group antigen (HBGA)-like molecules on enteric bacteria may enhance viral pathogenesis; however, the properties of these bacterial ligands are not well known. Previous work identified, but did not characterize, seven norovirus-binding bacteria. To further examine this bacteria–virus ...
Martínez-Carmona, Marina Izquierdo-Barba, Isabel Colilla, Montserrat Vallet-Regí, María
Published in
Acta biomaterialia
The ability of bacteria to form biofilms hinders any conventional treatment for chronic infections and has serious socio-economic implications. For this purpose, a nanocarrier capable of overcoming the barrier of the mucopolysaccharide matrix of the biofilm and releasing its loaded-antibiotic within this matrix would be desirable. Herein, we develo...
Wibowo, Agung A Pardjianto, Bambang Sumitro, Sutiman B Kania, Nia Handono, Kusworini
Published in
Biochemistry and biophysics reports
The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation ana...
Amini, Salah-Eddine Gouyer, Valérie Portal, Céline Gottrand, Frederic Desseyn, Jean-Luc
The nose is a complex organ that filters and warms breathing airflow. The nasal epithelium is the first barrier between the host and the external environment and is covered by a mucus gel that is poorly documented. Mucins are large, heavily O-glycosylated polymeric molecules secreted in the nose lumen by specialized cells, and they are responsible ...
Cavada, Benildo Sousa Osterne, Vinicius Jose Silva Lossio, Claudia Figueiredo Pinto-Junior, Vanir Reis Oliveira, Messias Vital Silva, Mayara Torquato Lima Leal, Rodrigo Bainy Nascimento, Kyria Santiago
Published in
International journal of biological macromolecules
Lectins are proteins that can bind specifically and reversibly to carbohydrates. This capacity gives lectins multiple biological roles and biotechnological applications. Although lectins can be found in all organisms, plant lectins, especially legume lectins, are undoubtedly the most thoroughly studied. Among legume lectins, the lectin from Canaval...
