Alsharif, Shaker T Almalki, Atiah H Ramzy, Sherif Sultan Alqahtani, Arwa Abduljabbar, Maram H Algarni, Majed A Serag, Ahmed
Published in
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Herein, two different sustainable and green signal processing spectrophotometric approaches, namely, derivative spectroscopy and wavelet transform, have been utilized for effective measurement of the antiretroviral therapy abacavir and lamivudine in their pharmaceutical formulations. These methods were used to enhance the spectral data and differen...
Chu, Carolyn Tao, Kaiming Kouamou, Vinie Avalos, Ava Scott, Jake Grant, Philip Rhee, Soo-Yon McCluskey, Suzanne Jordan, Michael Morgan, Rebecca
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BACKGROUND: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase strand transfer inhibitor (INSTI) drug-resistance mutations (DRMs) in individuals receiving DTG-containing ART. METHODS: We performed a...
Choi, Jonggi Choi, Won-Mook Lim, Young-Suk
Published in
Clinics in liver disease
In treatment-naïve patients with chronic hepatitis B virus (HBV) infection, entecavir (ETV), tenofovir disoproxil fumarate (TDF), and tenofovir alafenamide have a minimal or no risk of drug-resistance. These 3 nucleos(t)ide analog agents are highly potent inducing high rate of virologic response (reducing serum HBV DNA to levels undetectable by pol...
Kitamura, Rafael Shinji Akiyama Marques, Raizza Zorman Kubis, Gabrielly Cristina Kochi, Letícia Yoshi Barbato, Marcello Locatelli Maranho, Leila Teresinha Juneau, Philippe Gomes, Marcelo Pedrosa
Published in
Environmental pollution (Barking, Essex : 1987)
We investigated physiological responses of Lemna minor plants and their capacity to remove tenofovir (TNF; 412 ng l-1), lamivudine (LMV; 5428 ng l-1) and/or efavirenz (EFV; 4000 ng l-1) from water through phytoremediation. In addition, the toxicological safety of water contaminated with these drugs after treatment with L. minor plants to photosynth...
Ozdemir, Yusuf Emre Sahin Ozdemir, Meryem Bayramlar, Osman Faruk Surme, Serkan Yildiz Kaya, Sibel Karaali, Ridvan Balkan, Ilker Inanc Mete, Bilgul Saltoglu, Nese Tabak, Fehmi
...
Published in
Irish journal of medical science
We aimed to explore long-term results of oral antiviral agents in treatment-naïve "HBeAg negative chronic hepatitis B (CHB)" and determine the factors affecting the complete virological response. Patients with HBeAg-negative CHB who used oral antiviral agents for at least 3 years were evaluated retrospectively. A total of 173 patients were recorded...
Evitt, Lee A. Nanji, Sakina Grove, Richard A. Okoli, Chinyere van Wyk, Jean Snedecor, Sonya J.
Published in
AIDS Research and Therapy
Background The long-term efficacy and safety of the 2-drug regimen dolutegravir (DTG) + lamivudine (3TC) and 3-drug single-tablet regimens recommended for antiretroviral therapy (ART)-naive people with HIV-1 (PWH) have yet to be compared directly in clinical trials. This indirect treatment comparison (ITC) was conducted to compare the durability of...
a., alexander
The nature and strength of interactions for an anti-HIV drug, Lamivudine, were studied in a pure crystal form of the drug and the ligand–receptor complexes. High-resolution single-crystal X-ray diffraction studies of the tetragonal polymorph allowed the drug’s experimental charge density distribution in the solid state to be obtained. The QM/MM cal...
Fuller, Trevon Gouvêa, Maria Isabel de Lourdes Teixeira, Maria Medeiros, Adriana da Silva, Patricia Braga, Camile Sant'anna, Miriam Salgueiro, Mariza Bressan, Clarisse Mendes‐Silva, Wallace
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ObjectivesWe assessed real-world weight change and pregnancy outcomes among pregnant women living with HIV who used integrase strand transferase inhibitor (INSTI)-based combined antiretroviral therapy (cART).MethodsIn a retrospective cohort study from 2014 to 2021 for prevention of perinatal HIV infection, we evaluated changes in weight from the fi...
Tofukuji, Ayano Hongo, Haruyuki Nagao, Takako Sebata, Akemi Suzuki, Miwako Maeno, Yuko Kurosaki, Eiji Fukuda, Akiko Watanabe, Tomoyuki
Published in
Advances in Therapy
Introduction Since 2019, for the first time, a two-drug regimen with dolutegravir/lamivudine (DTG/3TC) has been recommended for HIV treatment as initial and subsequent therapy in the international guidelines. However, safety and efficacy data of DTG/3TC in Japanese people living with HIV (PLHIV) in clinical trials are limited and have not been eval...
Melvin, Ann J Yee, Ka Lai Gray, Kathryn P Yedla, Mounika Wan, Hong Tobin, Nicole H Teppler, Hedy Campbell, Havilland McCarthy, Katie Scheckter, Rachel
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BackgroundWe studied the pharmacokinetics (PK) and safety of 100-mg doravirine and doravirine/lamivudine/tenofovir disoproxil fumarate fixed-dose combination (100/300/300 mg DOR FDC) treatment in adolescents with HIV-1.MethodsAdolescents ages 12 to younger than 18 years were enrolled in 2 sequential cohorts. Cohort 1 evaluated intensive PK and shor...
