Sim, Hyuna Seo, Ji-Hye Kim, Jumi Oh, Minyoung Lee, Joo-Eun Baek, Areum Lee, Seo-Young Chung, Sun-Ku Son, Mi-Young Chae, Jung-Il
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Published in
Life
Parkinson’s disease (PD) is a common neurodegenerative disease, causing movement defects. The incidence of PD is constantly increasing and this disease is still incurable. Thus, understanding PD pathophysiology would be pivotal for the development of PD therapy, and various PD models have thus been already developed. Through recent advances in repr...
Ikezu, Tsuneya Koro, Lacin Wolozin, Benjamin Farraye, Francis A Strongosky, Audrey J Wszolek, Zbigniew K
Published in
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
The Leucine Rich Repeat Kinase 2 (LRRK2) is one of causative genes of familial Parkinson's disease (PD). The M2397T polymorphism in LRRK2 is genetically associated with sporadic Crohn's disease (CD). LRRK2 is expressed in human CD14+ monocytes, induced by interferon-γ (IFN-γ) and suppresses inflammatory activation. We hypothesize that IFN-γ-induced...
Jeong, Ga Ram Lee, Byoung Dae
Published in
Cells
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are common genetic risk factors for both familial and sporadic Parkinson’s disease (PD). Pathogenic mutations in LRRK2 have been shown to induce changes in its activity, and abnormal increase in LRRK2 kinase activity is thought to contribute to PD pathology. The precise molecular m...
Obsilova, Veronika Obsil, Tomas
Published in
International Journal of Molecular Sciences
Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of ...
Deshpande, Prasannakumar Flinkman, Dani Hong, Ye Goltseva, Elena Siino, Valentina Sun, Lihua Peltonen, Sirkku Elo, Laura L Kaasinen, Valtteri James, Peter
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Published in
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the pathological mechanism not only of inherited Parkinson's, but also of sporadic Parkinson's, the more common form. Here, we show that co...
Iannotta, Lucia; Biosa, Alice; Kluss, Jillian H; Tombesi, Giulia; Kaganovich, Alice; Cogo, Susanna; Plotegher, Nicoletta; Civiero, Laura; Lobbestael, Evy; 56414; Baekelandt, Veerle; 4499;
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Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among which Rab10. A comprehensive characterization of LR...
Melachroinou, Katerina Kang, Min Suk Liong, Christopher Narayan, Sushma Levers, Najah Joshi, Neal Kopil, Katie Hutten, Samantha J Baptista, Marco A S Padmanabhan, Shalini
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Published in
Movement disorders : official journal of the Movement Disorder Society
Leucine-rich repeat kinase 2 kinase inhibitors are being vigorously pursued as potential therapeutic options; however, there is a critical need for sensitive and quantitative assays of leucine-rich repeat kinase 2 function and target engagement. Our objective was to compare collection and storage protocols for peripheral blood mononuclear cells, an...
Ha, Jeongmin Kang, Ji Su Lee, Minhyung Baek, Areum Kim, Seongjun Chung, Sun-Ku Lee, Mi-Ok Kim, Janghwan
Published in
Frontiers in Cell and Developmental Biology
Although brain organoids are an innovative technique for studying human brain development and disease by replicating the structural and functional properties of the developing human brain, some limitations such as heterogeneity and long-term differentiation (over 2 months) impede their application in disease modeling and drug discovery. In this stu...
Menozzi, Elisa Macnaughtan, Jane Schapira, Anthony H V
Published in
Movement disorders : official journal of the Movement Disorder Society
Iannotta, Lucia Biosa, Alice Kluss, Jillian H. Tombesi, Giulia Kaganovich, Alice Cogo, Susanna Plotegher, Nicoletta Civiero, Laura Lobbestael, Evy Baekelandt, Veerle
...
Published in
Cells
Mutations in LRRK2 cause familial Parkinson’s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among which Rab10. A comprehensive characterization of LR...