Lefere, Sander Puengel, Tobias Hundertmark, Jana Penners, Christian Frank, Anna Katharina Guillot, Adrien de Muynck, Kevin Heymann, Felix Adarbes, Vanessa Defrêne, Evelyne
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Published in
Journal of hepatology
Peroxisome proliferator-activated receptors (PPARs) are essential regulators of whole-body metabolism, but also modulate inflammation in immune cells, notably macrophages. We compared the effects of selective PPAR agonists to those of the pan-PPAR agonist lanifibranor in non-alcoholic fatty liver disease (NAFLD), and studied isoform-specific effect...
Ronda, Onne AHO; 138409; van de Heijning, Bert JM; Martini, Ingrid; Gerding, Albert; Wolters, Justina C; van der Veen, Ydwine T; Koehorst, Martijn; Jurdzinski, Angelika; Havinga, Rick; van der Beek, Eline M;
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We recently reported that feeding mice in their early life a diet containing a lipid structure more similar to human milk (eIMF, Nuturis) results in lower body weights and fat mass gain upon high fat feeding in later life, compared to control (cIMF). To understand the underlying mechanisms, we now explored parameters possibly involved in this long-...
Omarjee, L Nitschke, Y Verschuere, S Bourrat, E Vignon, M-D Navasiolava, N Leftheriotis, G Kauffenstein, G Rutsch, F Vanakker, O M
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Published in
The British journal of dermatology
Pseudoxanthoma elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Overlap has been reported between the inherited PXE phenotype associated with ENPP1, ABCC6 or NT5E mutations and acquired PXE clinical manifestations associated with haemoglobinopathies induced by H...
Pakchotanon, Rattapol Ye, Justine Yang Cook, Richard J Chandran, Vinod Gladman, Dafna D
Published in
The Journal of rheumatology
We aimed to determine the prevalence and incidence, and to identify the factors associated with liver abnormalities in patients with psoriatic arthritis (PsA). From a longitudinal cohort study, we identified PsA patients with either elevated serum transaminase or alkaline phosphatase levels or liver disease after the first visit to the PsA clinic (...
Delahaye, Lisa Dhont, Evelyn De Cock, Pieter De Paepe, Peter Stove, Christophe P
Published in
Toxicology letters
Paracetamol (acetaminophen, APAP) is the most frequently used analgesic drug worldwide. However, patients in several specific populations can have an increased exposure to toxic APAP metabolites. Therefore, APAP-protein adducts have been proposed as an alternative marker for the assessment of APAP intoxications and as an effective tool to study and...
Cuff, AO Perchet, T Dertschnig, S Golub, R Male, V
Tbet‐deficient mice have reduced NK cells in blood and spleen, but increased NK cells in bone marrow and lymph nodes, a phenotype that is thought to be due to defective migration. Here, we revisit the role of Tbet in NK cell bone marrow egress. We definitively show that the accumulation of NK cells in the bone marrow of Tbet‐deficient Tbx21 ‐/‐ ani...
Van Wyngene, Lise Vanderhaeghen, Tineke Timmermans, Steven Vandewalle, Jolien Van Looveren, Kelly Souffriau, Jolien Wallaeys, Charlotte Eggermont, Melanie Ernst, Sam Van Hamme, Evelien
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Published in
EMBO molecular medicine
Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the notion that sepsis is accompanied by extensive metabolic perturbations. During times of limited caloric intake...
Van Wyngene, Lise; Vanderhaeghen, Tineke; Timmermans, Steven; Vandewalle, Jolien; Van Looveren, Kelly; Souffriau, Jolien; Wallaeys, Charlotte; Eggermont, Melanie; Ernst, Sam; Van Hamme, Evelien;
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Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the notion that sepsis is accompanied by extensive metabolic perturbations. During times of limited caloric intake...
Obata, Yuuki; Castano, Alvaro; Boeing, Stefan; Bon-Frauches, Ana Carina; Fung, Candice; 115231; Fallesen, Todd; De Aguero, Mercedes Gomez; Yilmaz, Bahtiyar; Lopes, Rita; Huseynova, Almaz;
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Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence, and is often dysregulated in gastrointestinal disorders1. Luminal factors, such as diet and microbiota, regulate neurogenic programs of gut motility2-5, but the underlying molecular...
Wang, Yufeng; Buyse, Johan; 12630; Courousse, Nathalie; Tesseraud, Sophie; Metayer-Coustard, Sonia; Berri, Cecile; Schallier, Seline; 102598; Everaert, Nadia; Collin, Anne;
The alpha-1 isoform of chicken AMPK situates on the Z-chromosome, in contrast, the other isoforms in birds and the mammalian AMPKα1 are located on the autosomes. The present study aimed to investigate the role of hepatic AMPK signaling in adaptation to nutritional status and the potential sex-specific response in chickens. Hepatic genes and protein...
