Reflecting their importance in immunity, the activity of chemokines is regulated on several levels, including tissue and context-specific expression and availability of their cognate receptor on target cells. Chemokine synergism, affecting both chemokine and chemokine receptor function, has emerged as an additional control mechanism. We previously ...
Cytochrome c Oxidase (CcO) is the terminal electron acceptor in aerobic respiratory chain, reducing O-2 to water. The released free energy is stored by pumping protons through the protein, maintaining the transmembrane electrochemical gradient. Protons are held transiently in a proton loading site (PLS) that binds and releases protons driven by the...
A gold(I)-catalyzed cascade transformation of N-alkynic 2-ynamides for the rapid and efficient synthesis of the indolizidine scaffold is developed. Through a sequential nucleophilic cyclization/enyne cycloisomerization/1,2-migration process, diverse pyrrolo[1,2-b]isoquinolines are obtained under mild conditions in a regiospecific and convergent man...
A novel Cd(II) supramolecular coordination framework containing mixed functionalized luminophore ligands, namely, [Cd(AS)2(phen)2]EtOH or 1 (where AS = 4-aminosalicylate, phen = 1,10-phenanthroline, EtOH = ethanol), was successfully synthesized as a solid-state luminescent sensor for the detection of amine vapors. The single-crystal X-ray diffracti...
status: published
status: published
Oxidative addition of aryl halides to Ni(0) is a ubiquitous elementary step in cross-coupling and related reactions, usually producing a square-planar Ni(II)-aryl intermediate. Here we show that a triphosphine ligand supports oxidative addition at a tris-ligated Ni(0) center to cleanly form stable five-coordinate Ni(II)-aryl compounds. Kinetic and ...
Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self...
Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self...
A new approach was suggested in present work for improving the separation between Pr(III) and Nd(III) by a so-called kinetic "push and pull" system consisting of [A336][NO3] and DTPA in a column extractor. It is revealed that, when organic extractant [A336][NO3] is continuously pumped into the column extractor in the form of dispersed oil droplets ...
