Jelstad, Stian Ditta Valsdottir, Thorhildur Johansen, Egil I Jensen, J Rgen
Published in
Archives of physiology and biochemistry
Exercise improves metabolic regulation and reduces the risk of developing type 2 diabetes and other metabolic diseases. The recommendations for exercise are rather general and the health benefits of controlled training studies are important to make better recommendations. In the present study, we report that eight endurance training sessions over 3...
Rymer, Jennifer A. Swaminathan, Rajesh V. Aday, Aaron W. Patel, Manesh R. Gutierrez, J. Antonio
Published in
Current Cardiology Reports
Purpose of ReviewThere is a lack of consistency among the ACC/AHA and ESC Guidelines on the treatment of patients with lower extremity PAD to a targeted LDL-c level. A review of the current guidelines, as well as the evidence that exists for use of various lipid-lower therapies in patients with PAD, is needed to guide clinical practice and to exami...
Galetti, Valeria Brnic, Marica Lotin, Benjamin Frigeri, Mauro
Published in
Nutrients
Fasting is becoming an increasingly popular practice. Nevertheless, its clinical benefits and possible inconveniences remain limitedly evaluated. We observed the effects of a seven-day fast conducted in a non-medical center located in the Swiss Alps. Clinical parameters were measured on the first and last day of fasting (D1 and D7), and two months ...
Gomez-Alonso, Monica del C. Kretschmer, Anja Wilson, Rory Pfeiffer, Liliane Karhunen, Ville Seppälä, Ilkka Zhang, Weihua Mittelstraß, Kirstin Wahl, Simone Matias-Garcia, Pamela R.
...
Published in
Clinical Epigenetics
BackgroundThe discovery of robust and trans-ethnically replicated DNA methylation markers of metabolic phenotypes, has hinted at a potential role of epigenetic mechanisms in lipid metabolism. However, DNA methylation and the lipid compositions and lipid concentrations of lipoprotein sizes have been scarcely studied. Here, we present an epigenome-wi...
Pimentel, Lígia L Rodríguez-Alcalá, Luis M
Published in
Biochimica et biophysica acta. Molecular and cell biology of lipids
Stefan, Elias
Background: Familial hypercholesterolemia (FH) is a genetic disorder estimated to affect 0,4 % of the world's population (1 in 250). Patients with FH have abnormally high LDL-cholesterol. Aim: The aim of this study was to estimate the prevalence of FH in Stockholm County and to evaluate the health economic impact of diagnosing people with FH early...
Shirzad, Fatemeh Morovatdar, Negar Rezaee, Ramin Tsarouhas, Konstantinos Abdollahi Moghadam, Alireza
Published in
Avicenna Journal of Phytomedicine
Objective: Cinnamon effect on blood pressure remains controversial. The present pilot study assessed cinnamon effect on blood pressure, and metabolic profile of stage 1 hypertension patients (S1HTN). Materials and Methods: This double-blind placebo-controlled randomized trial was conducted between June and October 2019, in Mashhad, Iran. Study incl...
Blencowe, Montgomery Ahn, In Sook Saleem, Zara Luk, Helen Cely, Ingrid Mäkinen, Ville-Petteri Zhao, Yuqi Yang, Xia
Published in
Journal of lipid research
Genome-wide association studies (GWAS) have implicated ~380 genetic loci for plasma lipid regulation. However, these loci only explain 17-27% of the trait variance and a comprehensive understanding of the molecular mechanisms has not been achieved. In this study, we utilized an integrative genomics approach leveraging diverse genomic data from huma...
Taj, Tahir Gliga, Anda R Hedmer, Maria Wahlberg, Karin Assarsson, Eva Lundh, Thomas Tinnerberg, Håkan Albin, Maria Broberg, Karin
Published in
Scandinavian Journal of Work, Environment & Health
Objective: This study investigated whether low-to-moderate exposure to welding fumes is associated with adverse effects on the cardiovascular system. Methods: To test this, we performed a longitudinal analysis of 78 mild steel welders and 96 controls; these subjects were examined twice, six years apart (ie, timepoints 1 and 2). All subjects (male a...
Bush, Jason R. Alfa, Michelle J.
Published in
BMC Nutrition
BackgroundPrebiotics, defined as a substrate that is selectively utilized by host microorganisms conferring a health benefit, present a potential option to optimize gut microbiome health. Elucidating the relationship between specific intestinal bacteria, prebiotic intake, and the health of the host remains a primary microbiome research goal.Objecti...
