Published in RNA biology
La-related proteins 7 (LARP7) are a class of RNA chaperones that bind the 3' ends of RNA and are constitutively associated with their specific target RNAs. In metazoa, Larp7 binds to the long non-coding 7SK RNA as a core component of the 7SK RNP, a major regulator of eukaryotic transcription. In the ciliate Tetrahymena the LARP7 protein p65 is a co...
Published in Frontiers in Neurology
Objective: The use of goggles to assess vertical semicircular canal function has become a standard method in vestibular testing, both in clinic and in research, but there are different methods and apparatus in use. The aim of this study was to determine what the cause of the systematic differences is between gain values in testing of the vertical s...
Published in RNA biology
RNA-binding proteins are important regulators of RNA metabolism and are of critical importance in all steps of the gene expression cascade. The role of aberrantly expressed RBPs in human disease is an exciting research field and the potential application of RBPs as a therapeutic target or a diagnostic marker represents a fast-growing area of resear...
Published in RNA biology
The RNA-binding protein LARP1 has generated interest in recent years for its role in the mTOR signalling cascade and its regulation of terminal oligopyrimidine (TOP) mRNA translation. Paradoxically, some scientists have shown that LARP1 represses TOP translation while others that LARP1 activates it. Here, we present opinions from four leading scien...
Published in RNA biology
The fate of any cellular RNA is largely influenced by the nature and diversity of its interactions with various RNA-binding proteins (RBPs) leading to the formation of a biologically significant ribonucleoprotein (RNP) complex. La motif-containing proteins (composed of genuine La and La-related proteins (LARPs)) represent an evolutionary conserved ...
Published in Journal of molecular biology
La is an abundant phosphoprotein that protects polymerase III transcripts from 3'-5' exonucleolytic degradation and facilitates their folding. Consisting of the evolutionary conserved La motif (LAM) and two consecutive RNA Recognition Motifs (RRMs), La was also found to bind additional RNA transcripts or RNA domains like internal ribosome entry sit...
この巻頭特別寄稿では, 第一線のエクスペリエンスデザイナーのヨハンナ コルヨネン氏が, オプトイン(LARPへの参加)/オプトアウト(LARPからの離脱)の原則に焦点を当てたLARP安全デザインの基本的な考慮事項を概説している. OKチェックイン, タップアウト, ルックダウンという三つの特殊な安全とキャリブレーション手法の歴史と応用を説明し, それらの使用を安全デザインのためのより広いシステムに統合している. / In this invited paper, leading experience designer Johanna Koljonen outlines basic considerations for larp safety design with a focus on opt...
A social safety team, called "social harassment support team, " found implementation at the "Drachenfest, " one of the largest European larp events with around C,
In this invited paper, leading experience designer Johanna Koljonen outlines basic considerations for larp safety design with a focus on opt-in/opt-out principles. She describes the history and application of three particular safety and calibration mechanics - the OK check-in, the tap-out, and the lookdown - and integrates their use into broader sy...
約5, 000人が参加するヨーロッパ最大級のLARPイベントである｢ドラッヘンフェスト｣では, ｢ソーシャルハラスメントサポートチーム｣と呼ばれる｢ソーシャルセーフティチーム(倫理問題対応チーム)｣が導入された. これは, 社会的に問題のある行動に対する社会的な認識が高まっており, LARPではそのような問題に対処するためのチームの需要が高まっていることから, 重要な意味を持つようになった. また, ｢ドラッヘンフェスト｣というユニークで挑戦的な環境は, 社会的安全性に関する先行研究ではまだ説明されていないものを実装することが求められていた. 本稿では, ベストプラクティス(最良慣行)の例として, ソーシャルセーフティチームの実装を紹介する. そのようなチームをどのように結成するかの詳細と,...
