Kyriakou, Kalia W. Lederer, Carsten Kleanthous, Marina Drousiotou, Anthi Malekkou, Anna
Published in
International Journal of Molecular Sciences
The ASAH1 gene encodes acid ceramidase (AC), an enzyme that is implicated in the metabolism of ceramide (Cer). Mutations in the ASAH1 gene cause two different disorders, Farber disease (FD), a rare lysosomal storage disorder, and a rare form of spinal muscular atrophy combined with progressive myoclonic epilepsy (SMA-PME). In the absence of human i...
Kim, Ji-Eun Park, Hana Choi, Seo-Hyeon Kong, Min-Jeong Kang, Tae-Cheon
Published in
Cells
Under physiological conditions, microglia are unique immune cells resident in the brain that is isolated from the systemic immune system by brain-blood barrier. Following status epilepticus (SE, a prolonged seizure activity), microglia are rapidly activated and blood-derived monocytes that infiltrate the brain; therefore, the regulations of microgl...
Wang, Xiaoping Li, Chun Wang, Qiyan Li, Weili Guo, Dongqing Zhang, Xuefeng Shao, Mingyan Chen, Xu Ma, Lin Zhang, Qian
...
Published in
Cancers
Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediators of autophagy. In this work, by assessing autop...
Pospíšil, Jakub Lukeš, Tomáš Bendesky, Justin Fliegel, Karel Spendier, Kathrin Hagen, Guy M
Published in
GigaScience
Background Structured illumination microscopy (SIM) is a family of methods in optical fluorescence microscopy that can achieve both optical sectioning and super-resolution effects. SIM is a valuable method for high-resolution imaging of fixed cells or tissues labeled with conventional fluorophores, as well as for imaging the dynamics of live cells ...
Gu, Xiaozhen Han, Miaomiao Du, Yang Wu, Yulan Xu, Yi Zhou, Xianxuan Ye, Danlei Wang, Hui-Li
Published in
Toxicology in vitro : an international journal published in association with BIBRA
Lead (Pb) has long been known as a metallic toxin to exert detrimental effects on human health, particularly on the central nervous system (CNS). Misregulated autophagy was regularly associated with multiple cellular dysfunctions and human diseases. However, the role of autophagy underlying Pb-induced neurotoxicity remains to be elucidated. In this...
Tsugawa, Hitoshi Mori, Hideki Matsuzaki, Juntaro Sato, Akira Saito, Yoshimasa Imoto, Masaya Suematsu, Makoto Suzuki, Hidekazu
Published in
Autophagy
Helicobacter pylori-derived CagA, a type IV secretion system effector, plays a role as an oncogenic driver in gastric epithelial cells. However, upon delivery into gastric epithelial cells, CagA is usually degraded by macroautophagy/autophagy. Hence, the induction of autophagy in H. pylori-infected epithelial cells is an important host-protective a...
Mamais, Adamantios Manzoni, Claudia Nazish, Iqra Arber, Charles Sonustun, Berkiye Wray, Selina Warner, Thomas T. Cookson, Mark R. Lewis, Patrick A. Bandopadhyay, Rina
...
Published in
Brain Research
LRRK2 , the gene encoding the multidomain kinase Leucine-Rich Repeat Kinase 2 (LRRK2), has been linked to familial and sporadic forms of Parkinson’s disease (PD), as well as cancer, leprosy and Crohn’s disease, establishing it as a target for discovery therapeutics. LRRK2 has been associated with a range of cellular processes, however its physiolog...
Gwalani, Lavesh A. Orange, Jordan S.
Published in
Journal of immunology (Baltimore, Md. : 1950)
Natural killer (NK) cells are cytotoxic lymphocytes important in defense against viral infection and cancer. NK cells mediate cytotoxicity predominantly through directed secretion of lytic granules which are specialized lysosome-related organelles, containing effector molecules such as perforin and granzymes. Although many requirements for lytic gr...
Zhou, Keren Enkhjargal, Budbazar Xie, Zhiyi Sun, Chengmei Wu, Lingyun Malaguit, Jay Chen, Sheng Tang, Jiping Zhang, Jianmin Zhang, John H.
...
Published in
Stroke
Background and Purpose The NLRP3 inflammasome is a crucial component of the inflammatory response in early brain injury (EBI) after subarachnoid hemorrhage (SAH). In this study we investigated a role of dihydrolipoic acid (DHLA) in lysosomal rupture, NLRP3 activation, and determined the underlying pathway. Methods SAH was induced by endovascular pe...
Xu, Yunzhao Cao, Xuemin Zhang, Shu Zhang, Yuquan Shen, Zongji
Published in
International Journal of Clinical and Experimental Pathology
Lysosome Associated Membrane Protein-1 (LAMP1), expressed in several functional processes, is a heavily glycosylated lysosomal membrane protein which is able to protect the lysosomal membranes from intracellular proteolysis. Its pro-tumorigenic effects are involved in the development of several types of Malignancy. However, the role of LAMP1 in hum...
