Chen, Chien-Jen You, San-Lin Hsu, Wan-Lun Yang, Hwai-I Lee, Mei-Hsuan Chen, Hui-Chi Chen, Yun-Yuan Liu, Jessica Hu, Hui-Han Lin, Yu-Ju
...
Published in
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Seven viruses including the Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), Kaposi's sarcoma herpes virus (KSHV), human immunodeficiency virus, type-1 (HIV-1), human T cell lymphotrophic virus, type-1 (HTLV-1), and human papillomavirus (HPV) have been classified as Group 1 human carcinogens by the International Agency fo...
Iftode, Nicoleta Rădulescu, Mihaela Andreea Aramă, Ștefan Sorin Aramă, Victoria
Published in
Romanian Journal of Internal Medicine
Human herpesvirus 8 (HHV8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), is one of the few pathogens recognized as direct carcinogen, being involved in the pathogenesis of Kaposi sarcoma, primary effusion lymphoma and multicentric Castleman disease. KSHV is a relatively recently discovered virus, with still limited possibilities for ...
Sabourin, Katherine R. Ogolla, Sidney Daud, Ibrahim I. Jackson, Conner L. Miley, Wendell Labo, Nazzarena Whitby, Denise Rochford, Rosemary
Published in
Infectious Agents and Cancer
BackgroundKaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in sub-Saharan African children can range up to 50% by age 2 years but factors affecting early age of KSHV infection are not well understood. Malaria during pregnancy has been associated with hindered transplacental transfer of antibodies to several pathogens but whether it affec...
Markazi, Ashley Bracci, Paige M McGrath, Michael Gao, Shou-Jiang
Inflammation triggered by innate immunity promotes carcinogenesis in cancer. Kaposi's sarcoma (KS), a hyperproliferative and inflammatory tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection, is the most common cancer in AIDS patients. KSHV infection sensitizes cells to pathogen-associated molecular patterns (PAMPs). We examined...
Charostad, J. Nakhaie, M. Dehghani, A. Faghihloo, E.
Published in
Infectious Agents and Cancer
Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role ...
Gabaev, Ildar Williamson, James C. Crozier, Thomas W.M. Schulz, Thomas F. Lehner, Paul J.
Published in
Cell Reports
Gabaev et al. describe how a human oncogenic herpesvirus, KSHV, changes the proteome of endothelial cells and modulates the host immune system. By targeting KSHV with CRISPR, they show that viral K5 protein downregulates ligands for the NK cell DNAM-1 receptor and antiviral protein PKR is depleted in an K5-independent manner.
Pei, Yonggang Wong, Josiah Hiu-yuen Robertson, Erle S.
Among all of the known biological carcinogens, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two of the classical oncogenic herpesviruses known to induce the oncogenic phenotype. Many studies have revealed important functions related to epigenetic alterations of the EBV and KSHV genomes that mediate oncogenesis, bu...
Pei, Yonggang Wong, Josiah Hiu-yuen Robertson, Erle S.
Among all of the known biological carcinogens, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two of the classical oncogenic herpesviruses known to induce the oncogenic phenotype. Many studies have revealed important functions related to epigenetic alterations of the EBV and KSHV genomes that mediate oncogenesis, bu...
Alomari, Nedaa Totonchy, Jennifer
Published in
Viruses
Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory ...
Macveigh-Fierro, Daniel Rodriguez, William Miles, Jacob Muller, Mandy
Published in
Viruses
Kaposi’s sarcoma-associated herpesvirus (KSHV) induces life-long infections and has evolved many ways to exert extensive control over its host’s transcriptional and post-transcriptional machinery to gain better access to resources and dampened immune sensing. The hallmark of this takeover is how KSHV reshapes RNA fate both to control expression of ...
