Kubouchi, Koji Mukai, Hideyuki
Published in
Biochemistry and Biophysics Reports
• PKN2 is involved in initial fibroblast aggregation by regulating cell motility. • PKN2 is involved in compaction of fibroblasts in suspension. • N-cadherin protein level seems to be a key element for compaction of fibroblasts. • PKN2 controls transcription of N-cadherin mRNA in fibroblasts.
Lin, Chun-Jung Dang, Andrew Hernandez, Elizabeth Hsieh, Jer-Tsong
Published in
Neoplasia (New York, N.Y.)
Primary cilium is a microtubule-based organelle that projects from the surfaces of most mammalian cell types and protrudes into the extracellular milieu as an antenna-like sensor to senses extracellular physical and biochemical signals, and then transmits signals into cytoplasm or nucleus to regulate numerous physical and developmental processes. T...
Bartneck, Matthias Koppe, Christiane Fech, Viktor Warzecha, Klaudia T Kohlhepp, Marlene Huss, Sebastian Weiskirchen, Ralf Trautwein, Christian Luedde, Tom Tacke, Frank
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Published in
Cellular and molecular gastroenterology and hepatology
Macrophages are key regulators of inflammation and cancer promotion in the liver, and their recruitment and activation is linked to chemokine receptor signaling. However, the exact roles of the chemokine receptors CCR2 and CCR5 for macrophage functions in the liver is obscure. To study CCR2 and CCR5 in inflammatory liver injury, we used mice with a...
Lee, Jungsoo Kim, Bomi Chu, Howard Zhang, KeLun Kim, Hyeran Kim, Ji Hye Kim, Seo Hyeong Pan, Youdong Noh, Ji Yeon Sun, ZhengWang
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Published in
EBioMedicine
While the incidence of patients with atopic dermatitis (AD) with atopic march (AM) showing respiratory allergy is steadily rising, the pathomechanism is still unknown. There are currently no biomarkers to predict progression of AM. To explore the mechanism of AM, patients with AD and AM and healthy controls were recruited and RNA microarray, flow c...
Zhang, Xiaowei Zhang, Ping An, Lin Sun, Ningyuan Peng, Liying Tang, Weiwei Ma, Dingyuan Chen, Jun
Published in
Acta Pharmaceutica Sinica. B
Miltirone might be a potential candidate agent for the treatment of HCC. A central signaling axis, ROS/ERK1/2–BAX–caspase 9–caspase 3–gasdermin E (GSDME), was demonstrated to regulate the miltirone-induced pyroptotic process Image 1
Zhang, Yong-Guo Lu, Rong Wu, Shaoping Chatterjee, Ishita Zhou, David Xia, Yinglin Sun, Jun
Published in
Cellular and molecular gastroenterology and hepatology
Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome. Human Vdr gene variation shapes the microbiome and VDR deletion leads to dysbiosis. Low VDR expression and diminished vitamin D/VDR signaling are observed in colon cancer. Nevertheless, how intest...
Trovò, L. Fuchs, C. De Rosa, R. Barbiero, I. Tramarin, M. Ciani, E. Rusconi, L. Kilstrup-Nielsen, C.
Published in
Neurobiology of Disease
• Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • Epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro; • DYRK1A levels and activity is increased in CDKL5 deficient neurons;
Ma, Xinrun Shang, Xuyang Qin, Xuan Lu, Jian Liu, Mingyao Wang, Xin
Published in
Acta pharmaceutica Sinica. B
Organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1/3) as important uptake transporters play a fundamental role in the transportation of exogenous drugs and endogenous substances into cells. Rat OATP1B2, encoded by the Slco1b2 gene, is homologous to human OATP1B1/3. Although OATP1B1/3 is very important, few animal models can be used to stud...
Donkers, Joanne M. Roscam Abbing, Reinout L.P. van Weeghel, Michel Levels, Johannes H.M. Boelen, Anita Schinkel, Alfred H. Oude Elferink, Ronald P.J. van de Graaf, Stan F.J.
Published in
Cellular and Molecular Gastroenterology and Hepatology
Zhong, Xiaolin Huang, Menghao Kim, Hyeong-Geug Zhang, Yang Chowdhury, Kushan Cai, Wenjie Saxena, Romil Schwabe, Robert F. Liangpunsakul, Suthat Dong, X. Charlie
...
Published in
Cellular and Molecular Gastroenterology and Hepatology