Jia, Yan-Shuang Yang, Ling Zhu, Yong-Qing Ma, Cheng-Bin
Published in
American Journal of Translational Research
Objectives: Ovarian cancer (OC) ranks fifth among the main causes of cancer-related deaths in women worldwide. PCLAF/KIAA0101 and Yes-associated protein (YAP) have been linked to several human malignant cancers, including OC. However, the roles of KIAA0101 and YAP in glycolysis-dependent OC cell proliferation remain unknown. Methods: qRT-PCR and we...
Sun, Zhiguang Zhang, Shaowei Zhang, Nan Wang, Jianxin Wang, Jindong Liu, Junfeng
Published in
Thoracic cancer
Circular RNAs (circRNAs) can act as key regulators in human cancers, including esophageal squamous cell carcinoma (ESCC). However, the role and mechanism of circ_0005231 in ESCC have not previously been reported. RNA levels and protein levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR) and Western blot assay, respect...
Wang, Kai Li, Jinxiao Zhou, Botao
Published in
Metabolic brain disease
KIAA0101, a proliferating cell nuclear antigen (PCNA)-associated factor, is reported to be overexpressed and identified as an oncogene in several human malignancies. The purpose of this study is to determine the function and possible mechanism of KIAA0101 in glioma progression. KIAA0101 expression in glioma patients was analyzed by GSE50161 and GEP...
Liu, Jiuyang He, Yukun Li, Chengxin Zhou, Rui Yuan, Qianqian Hou, Jinxuan Wu, Gaosong
Published in
Translational Cancer Research
Background Breast cancer (BC) has long been a major death threat facing women worldwide. With the development of comprehensive treatment methods, the prognosis of BC was improved but still unsatisfactory. This study was aimed to identify the key genes in BC tumorigenesis and investigate potential prognostic predictors. Methods Differential expressi...
Kim, Moon Jong Cervantes, Christopher Jung, Youn-Sang Zhang, Xiaoshan Zhang, Jie Lee, Sung Ho Jun, Sohee Litovchick, Larisa Wang, Wenqi Chen, Junjie
...
Published in
Molecular Cell
Bypassing cell quiescence and cell-cycle arrest is a crucial step for tumorigenesis. Here, Kim et al. show that a PAF-remodeled DREAM complex induces the global expression of cell-cycle genes, thereby evading quiescence and promoting lung tumorigenesis.
Zhang, Qing Yuan, Jingjing Liu, Yanyan Liu, Xingchen Lv, Tianxin Zhou, Keshu Song, Yongping
Published in
Annals of translational medicine
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with intense cytogenetic aberrations. Importantly, our recent report indicated that thyroid hormone receptor interactor 13 (TRIP13) is a potential new therapeutic target in CLL. In this study, we predicted 20 TRIP13-related genes and found that KIAA0101 is a novel gene that regulates cel...
Sun, Tuanhe An, Qi Yan, Rong Li, Kang Zhu, Kun Dang, Chengxue Yuan, Dawei
Published in
Oncology reports
The KIAA0101 protein (also referred to as NS5ATP9 or Paf15) is overexpressed in esophageal squamous cell carcinoma (ESCC) and is associated with disease progression and poor patient survival, but how KIAA0101 expression is regulated remains unknown. The relationship between tumor miR‑216a‑5p expression and prognosis in patients with ESCC was reveal...
Lei, Han Wang, Kun Jiang, Tongying Lu, Jingjing Dong, Xue Wang, Feilong Li, Qiang Zhao, Liming
Published in
BMC Cancer
BackgroundChromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel therapy for non-small cell lung cancer (NSCLC). UbcH10 is considered to be associated with SAC function and the pathological types and c...
Cao, He Zheng, Jing Yao, Yinan Yang, Qi Yan, Runlan Sun, Wenjia Ruan, Kexin Zhou, Jianya Zhou, Jianying
Published in
Journal of Cancer
Lung cancer is the leading cause of cancer related death worldwide, with a continue-rising incidence. The proliferating cell nuclear antigen binding protein KIAA0101 is highly expressed in various types of cancer, including non-small cell lung cancer (NSCLC). However, its biological role and underlying mechanisms in NSCLC remains unclear. We downlo...
Xu, Weiyu Wang, Xuezhu Wu, Xiaoqian Yu, Si Xiong, Jianping Sang, Xinting Zheng, Yongchang Zhang, Zhongtao
Published in
Aging (Albany NY)
Although KIAA0101 is involved in many diseases, its expression and prognostic value in HCC remain undefined. According to CCLE, KIAA0101 is highly expressed in HCC, with a weak positive correlation between copy number and gene expression. Four studies involving 760 samples in ONCOMINE report elevated KIAA0101 expression in HCC (p=3.11E-22). The KM ...
