Waelchli, Thomas; Ghobrial, Moheb; Schwab, Marc; Takada, Shigeki; Zhong, Hang; Suntharalingham, Samuel; Vetiska, Sandra; Gonzalez, Dayme Rodrigues; Wu, Ruilin; Rehrauer, Hubert;
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A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood1. Here we performed single-cell RNA sequencing analysis of 606,380 freshly isolated endothelial ce...
Garcia-Beltran, Cristina; Malpique, Rita; Andersen, Marianne S.; Bas, Firdevs; Bassols, Judit; Darendeliler, Feyza; Diaz, Marta; Dieris, Barbara; Fanelli, Flaminia; Froehlich-Reiterer, Elke;
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BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent, chronic endocrine-metabolic disorder of adolescents and young women (AYAs), affecting 5-10% of AYAs worldwide. There is no approved pharmacological therapy for PCOS. Standard off-label treatment with oral contraceptives (OCs) reverts neither the underlying pathophysiology nor the a...
Pottie, Lore Van Gool, Wouter Vanhooydonck, Michiel Hanisch, Franz-Georg Goeminne, Geert Rajkovic, Andreja Coucke, Paul Sips, Patrick Callewaert, Bert
Author summary Cutis laxa syndromes are pleiotropic disorders of the connective tissue, characterized by skin redundancy and variable systemic manifestations. Cutis laxa syndromes are caused by pathogenic variants in genes encoding structural and regulatory components of the extracellular matrix or in genes encoding components of cellular trafficki...
Pereira, Marie Chen, Tai-Di Buang, Norzawani Olona, Antoni Ko, Jeong-Hun Prendecki, Maria Costa, Ana S H Nikitopoulou, Efterpi Tronci, Laura Pusey, Charles D
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Published in
Cell reports
Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but an integrative view of transcriptional and metabolic responses to iron perturbation in macrophages is lacking. Here, we induced acute iron chelation in primary human macrophages and measured their transcriptional and metabolic responses. Acu...
Nikolantonaki, Maria Darriet, Philippe
Published in
Journal of agricultural and food chemistry
A number of Sauvignon blanc wines made from hard pressed juices in an inert atmosphere (nitrogen) or in contact with oxygen were identified as having heavy off-flavors to varying degrees. Samples were extracted and subjected to time-based HPLC fractionation. The fractions were assessed by a sensory panel and those with unpleasant, irritating, off-o...
Stevens, M.G.H. Van Poucke, M. Peelman, L.J. Rainard, Pascal De Spiegeleer, B. Rogiers, C. Van De Walle, G.R. Duchateau, Laure Burvenich, Christian
Deka, Jürgen Wiedemann, Norbert Anderle, Pascale Murphy-Seiler, Fabienne Bultinck, Jennyfer Eyckerman, Sven Stehle, Jean-Christophe André, Sylvie Vilain, Nathalie Zilian, Olav
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Published in
Cancer research
Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is required for Armadillo/beta-catenin signaling. Conditional ablation of Bcl9/Bcl9l in the inte...
Cho, JI Ryoo, N Eom, JS Lee, DW Kim, HB Jeong, SW Lee, YH Kwon, YK Cho, MH Bhoo, SH
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The Arabidopsis (Arabidopsis thaliana) hexokinase 1 (AtHXK1) is recognized as an important glucose (Glc) sensor. However, the function of hexokinases as Glc sensors has not been clearly demonstrated in other plant species, including rice (Oryza sativa). To investigate the functions of rice hexokinase isoforms, we characterized OsHXK5 and OsHXK6, wh...
Lim, JH Hwang, KY Choi, JY Lee, DY Ahn, BYY Cho, YJ Kim, KS Han, YS
We designed two mutants of superoxide dismutase (SOD), one is thermostable and the other is thermolabile, which provide valuable insight to identify amino acid residues essential for the thermostability of the SOD from Aquifex pyrophilus (ApSOD). The mutant K12A, in which Lys12 was replaced by Ala, had increased thermostability compared to that of ...