Arve-Butler, Sabine Schmidt, Tobias Mossberg, Anki Berthold, Elisabet Gullstrand, Birgitta Bengtsson, Anders A. Kahn, Fredrik Kahn, Robin
Published in
Arthritis Research & Therapy
BackgroundNeutrophils are the most prevalent immune cells in the synovial fluid in inflamed joints of children with oligoarticular juvenile idiopathic arthritis (JIA). Despite this, little is known about neutrophil function at the site of inflammation in JIA and how local neutrophils contribute to disease pathogenesis. This study aimed to character...
Verwoerd, Anouk Armbrust, Wineke Cowan, Katherine van den Berg, Lotte de Boer, Joke Bookelman, Sanne Britstra, Marjan Cappon, Jeannette Certan, Maria Dedding, Christine
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Published in
Pediatric Rheumatology
BackgroundInvolving the end-users of scientific research (patients, carers and clinicians) in setting research priorities is important to formulate research questions that truly make a difference and are in tune with the needs of patients. We therefore aimed to generate a national research agenda for Juvenile Idiopathic Arthritis (JIA) together wit...
Shin, Yoonkyeom Kang, Ji-Man Lee, Junwon Lee, Christopher Seungkyu Lee, Sung Chul Ahn, Jong Gyun
Published in
Pediatric Rheumatology
BackgroundThe early detection of uveitis associated with systemic inflammatory disease in children is important for proper treatment and prognosis. However, the diagnosis may be delayed because of difficulties in childhood examinations and early minor systemic symptoms. The objective of our study was to identify the pattern of childhood uveitis and...
Kyvsgaard, Nini Mikkelsen, Torben Stamm Als, Thomas D. Christensen, Anne Estmann Corydon, Thomas J. Herlin, Troels
Published in
Pediatric Rheumatology
BackgroundContext: Methotrexate (MTX) is a cornerstone in the treatment of juvenile idiopathic arthritis (JIA). MTX treatment is commonly associated with nausea. Large inter-individual variation exists in the level of MTX-induced nausea, possibly due to genetic factors.Purpose: To investigate whether MTX-induced nausea was associated with single nu...
de Gruijter, Nina M. Naja, Meena Peckham, Hannah Radziszewska, Anna Kinsella, Matthew Glenister, James Rosser, Elizabeth C. Butler, Gary E. Jury, Elizabeth C. Ciurtin, Coziana
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Published in
Pediatric Rheumatology
BackgroundAutoimmune rheumatic diseases (ARDs) are associated with a significant sex-bias, which becomes more evident post-puberty. This systematic review aims to elucidate the bidirectional relationship between puberty and ARD-related outcomes.MethodsStudies published in English until October 2019 were identified using a systematic search of endoc...
Rapley, Tim May, Carl Smith, Nicola Foster, Helen E.
Published in
Pediatric Rheumatology
BackgroundMany children and young people with juvenile idiopathic arthritis (JIA) experience delay in diagnosis and access to right care. The reasons for delay are multi-factorial and influenced by patient and family, clinician and organisational factors. Our aim was to explore the experiences of care, from initial symptoms to initial referral to p...
Doeleman, Martijn J. H. de Roock, Sytze Buijsse, Nathan Klein, Mark Bonsel, Gouke J. Seyfert-Margolis, Vicki Swart, Joost F. Wulffraat, Nico M.
Published in
Pediatric Rheumatology
BackgroundPediatric patients with juvenile idiopathic arthritis (JIA) are at risk for a lower health-related quality of life compared to their healthy peers. Remote monitoring of health-related quality of life using electronic patient-reported outcomes could provide important information to treating physicians. The aim of this study was to investig...
d’Angelo, Debora Mariarita Di Donato, Giulia Breda, Luciana Chiarelli, Francesco
Published in
Pediatric Rheumatology
Juvenile Idiopathic Arthritis is one of the most prevalent chronic diseases in children, with an annual incidence of 2–20 cases per 100,000 and a prevalence of 16–150 per 100,000. It is associated with several complications that can cause short-term or long-term disability and reduce the quality of life. Among these, growth and pubertal disorders p...
Hildebrandt, Julia Rahn, Anja Kessler, Anja Speth, Fabian Fischer, Dagmar-Christiane Ballmann, Manfred
Published in
Pediatric Rheumatology
BackgroundIn adults with rheumatic diseases pulmonary complications are relevant contributors to morbidity and mortality. In these patients diffusion capacity for CO (DLCO) is an established method to detect early pulmonary impairment. Pilot studies using DLCO indicate that early functional pulmonary impairment is present even in children with rheu...
Reyhan, Iris Zhukov, Olga S. Lagier, Robert J. Bridgforth, Robert F. Williams, Gary J. Popov, Joanna M. Naides, Stanley J. Reiff, Andreas
Published in
Pediatric Rheumatology Online Journal
Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14–3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody in adult rheumatoid arthritis (RA), and have been associated with more severe phenotype. We inves...
