Takahashi, Masanobu Kato, Ken Okada, Morihito Chin, Keisho Kadowaki, Shigenori Hamamoto, Yasuo Doki, Yuichiro Kubota, Yutaro Kawakami, Hisato Ogata, Takashi
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Published in
Esophagus : official journal of the Japan Esophageal Society
The efficacy and safety of nivolumab versus chemotherapy was evaluated in the Japanese subpopulation from the overall intent-to-treat (ITT) population of the ATTRACTION-3 trial conducted in patients with advanced esophageal squamous cell carcinoma (ESCC) as second-line treatment. Data from Japanese patients enrolled in the multicenter, randomized, ...
Gervais, Olivier Ueno, Kazuko Kawai, Yosuke Hitomi, Yuki Misawa, Kazuharu Teraguchi, Shunsuke Wang, Yen-Yen Tokunaga, Katsushi Nagasaki, Masao
Published in
G3 (Bethesda, Md.)
Over the past few decades, obesity has become a public health issue of global concern. Even though disparities exist between human populations, e.g., the higher liver fat content of the Japanese despite a lower body mass index (BMI), studies on the genetics of obesity still largely focus on populations of European descent, leading to a dearth of ge...
Hashimoto, Shiho Nakajima, Fumiaki Imanishi, Tadashi Kawai, Yosuke Kato, Kazue Kimura, Takafumi Miyata, Shigeki Takanashi, Minoko Nishio, Miwako Tokunaga, Katsushi
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Published in
HLA
Japan is an island country, and the Japanese people have had minimal genetic exchange with other ethnolinguistic groups. Consequently, the population is highly uniform and has limited HLA diversity relative to people from other countries. However, Japan has three ethnolinguistic groups, and HLA distributions differ depending on geographic region. T...
Matsumura, Tomohiro Takahashi, Tsuneari Nakashima, Mitsuharu Nibe, Yoshiya Takeshita, Katsushi
Published in
Geriatric Orthopaedic Surgery & Rehabilitation
Introduction: The TFN-ADVANCED Proximal Femoral Nailing System (TFNA) 235 mm (DePuySynthes) and Proximal Femoral Nail Antirotation (PFNA)-II 240 mm (DePuySynthes) were developed to obtain better stability for patients with trochanteric hip fractures without increasing surgical time and amount of blood loss. However, there are currently no studies c...
Suzuki, Koji Shivappa, Nitin Kawado, Miyuki Yamada, Hiroya Hashimoto, Shuji Wakai, Kenji Iso, Hiroyasu Okada, Emiko Fujii, Ryosuke Hébert, James R.
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Published in
Nagoya Journal of Medical Science
Diet plays an important role in the regulation of chronic inflammation, which is linked to cardiovascular disease (CVD) and several cancers. The dietary inflammatory index (DII®) was developed to estimate the inflammatory potential of an individual’s diet. We examined the association between DII scores and serum high-sensitivity C-reactive protein ...
Sekino, Satoshi Takahashi, Ryoichi Numabe, Yukihiro Okamoto, Hiroshi
Published in
BMC Oral Health
BackgroundTo date, a few studies have documented the detailed periodontal conditions of a Japanese population. It is important to know if the awareness of Japanese nationals and dentists regarding oral hygiene and prevention of periodontal disease have improved when compared with the past in Japan for the development of future scenarios regarding p...
Yamashita, Tatsuya Kudo, Masatoshi Ikeda, Kenji Izumi, Namiki Tateishi, Ryosuke Ikeda, Masafumi Aikata, Hiroshi Kawaguchi, Yasunori Wada, Yoshiyuki Numata, Kazushi
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Published in
Journal of gastroenterology
A phase 3, multinational, randomized, non-inferiority trial (REFLECT) compared the efficacy and safety of lenvatinib (LEN) and sorafenib (SOR) in patients with unresectable hepatocellular carcinoma (uHCC). LEN had an effect on overall survival (OS) compared to SOR, statistically confirmed by non-inferiority [OS: median = 13.6 months vs. 12.3 months...
Sentani, Kazuhiro Ogawa, Ikuko Ozasa, Kotaro Sadakane, Atsuko Utada, Mai Tsuya, Takafumi Kajihara, Hiroki Yonehara, Shuji Takeshima, Yukio Yasui, Wataru
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Published in
Journal of Clinical Medicine
Salivary gland neoplasms are uncommon, and their epidemiology in Japan has not been well described. We conducted a retrospective review of salivary gland tumors registered in the Hiroshima Tumor Tissue Registry over a period of 39 years. The subjects were 5015 cases ranging in age from 6 to 97 (mean, 54.3) years old. The incidence of both benign tu...
Kushima, Itaru Aleksic, Branko Nakatochi, Masahiro Shimamura, Teppei Okada, Takashi Uno, Yota Morikawa, Mako Ishizuka, Kanako Shiino, Tomoko Kimura, Hiroki
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Published in
Cell reports
Compelling evidence in Caucasian populations suggests a role for copy-number variations (CNVs) in autism spectrum disorder (ASD) and schizophrenia (SCZ). We analyzed 1,108 ASD cases, 2,458 SCZ cases, and 2,095 controls in a Japanese population and confirmed an increased burden of rare exonic CNVs in both disorders. Clinically significant (or pathog...
Ikeda, Tomoya Miyamoto, Kazunori Tani, Naoto Oritani, Shigeki Michiue, Tomomi Morioka, Fumiya Ishikawa, Takaki
Published in
Egyptian Journal of Forensic Sciences
BackgroundSex estimation from fragmented or isolated human bones found during excavations is imperative not only in the field of forensics but also paleoanthropology. This study investigated the possibility of sex estimation from computed tomography (CT) data for the lengths of the index and ring fingers. The scans were obtained using a multislice ...
