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with JAK/STAT signalling as keyword
Bernal, Susana Lopez-Sanz, Laura Jimenez-Castilla, Luna Prieto, Ignacio Melgar, Ana La Manna, Sara Martin-Ventura, Jose Luis Blanco-Colio, Luis Miguel Egido, Jesus Gomez-Guerrero, Carmen
...
Published in
British journal of pharmacology
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress and proteolytic activity in the aortic wall. Targeting JAK/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculo-protective role of s...
Bernal, Susana Lopez-Sanz, Laura Jimenez-Castilla, Luna Prieto, Ignacio Melgar, Ana La Manna, Sara Martin-Ventura, Jose Luis Blanco-Colio, Luis Miguel Egido, Jesus Gomez-Guerrero, Carmen
...
Published in
British journal of pharmacology
Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Targeting Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is a promising strategy for chronic inflammatory diseases. We investigated the vasculoprotective ...
Menet, Christel J. Rompaey, Luc Van Geney, Raphaël
Published in
Progress in Medicinal Chemistry
In this review, we describe the current knowledge of the biology of the JAKs. The JAK family comprises the four nonreceptor tyrosine kinases JAK1, JAK2, JAK3, and Tyk2, all key players in the signal transduction from cytokine receptors to transcription factor activation. We also review the progresses made towards the optimization of JAK inhibitors ...
Caffarel, M M Zaragoza, R Pensa, S Li, J Green, A R Watson, C J
Published in
Cell death and differentiation
Signalling through the janus kinase (JAK)/signal transducer and activator of transcription (Stat) pathway is required at different stages of mammary gland development, and this pathway is frequently hyper-activated in cancer, including tumours of the breast. Stats 3, 5 and 6 have important roles in the differentiation and survival of mammary alveol...
Rakesh, Kriti Agrawal, Devendra K.
Published in
Biochemical Pharmacology
Cytokines are secreted proteins that regulate diverse biological functions by binding to receptors at the cell surface to activate complex signal transduction pathways including the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Stringent mechanisms of signal attenuation are essential for ensuring an appropriate, ...
