Cavalcante Silva, Jacqueline Bavestrello, Margherita Gazzola, Valerio Spinella, Giovanni Pane, Bianca Grasselli, Elena Demori, Ilaria Canesi, Laura Emionite, Laura Cilli, Michele
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Published in
Life sciences
Ischemia-Reperfusion (I/R) damage is one of the major challenges in cardiothoracic surgeries and in a pathological manner, is identified by exacerbated damage signals resulted from blood supply restriction and subsequent flow restoration and re‑oxygenation. I/R damage includes cellular dysfunction and death, impairing tissue and organ function. Inf...
Shanmugam, Karthi Prem, Priyanka N Boovarahan, Sri Rahavi Sivakumar, Bhavana Kurian, Gino A
Published in
Cell biochemistry and biophysics
According to our previous study, fisetin (3,3',4',7-tetrahydroxyflavone), a bioactive phytochemical (flavonol), reportedly showed cardioprotection against ischemia-reperfusion injury (IRI) by reducing oxidative stress and inhibiting glycogen synthase kinase 3β (GSK3β) [1]. GSK3β is said to exert a non-mitochondrial mediated cardioprotection; theref...
Granado, M González-Hedström, D Amor, S Fajardo-Vidal, A Villalva, M de la Fuente-Fernández, M Tejera-Muñoz, A Jaime, L Santoyo, S García-Villalón, A L
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Published in
Journal of ethnopharmacology
Marjoram (Origanum majorana L.) is an herb traditionally used as a medicine in different countries, as Morocco and Iran, because of its beneficial cardiovascular effects. Some studies suggest that these effects are due, at least in part, to the presence of phenolic compounds such as rosmarinic acid (RA) and luteolin. To analyze the possible cardipr...
Boulghobra, Doria Dubois, Mathilde Alpha-Bazin, Béatrice Coste, Florence Olmos, Maxime Gayrard, Sandrine Bornard, Isabelle Meyer, Gregory Gaillard, Jean-Charles Armengaud, Jean
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Published in
Basic Research in Cardiology
Endothelial nitric oxide synthase (eNOS) activation in the heart plays a key role in exercise-induced cardioprotection during ischemia–reperfusion, but the underlying mechanisms remain unknown. We hypothesized that the cardioprotective effect of exercise training could be explained by the re-localization of eNOS-dependent nitric oxide (NO)/S-nitros...
Pekoglu, Esra Buyukakilli, Belgin Turkseven, Cagatay Han Balli, Ebru Bayrak, Gulsen Cimen, Burak Balci, Senay
Published in
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Ischemia-reperfusion (I-R) injury is a serious problem caused by vascular trauma, tourniquet use and/or compartment syndrome. Studies have reported that skeletal muscle function is impaired due to the lower extremity I-R injury. There are insufficient studies on the treatment methods used for the recovery of dysfunction. This study is designed to i...
Ville, Simon Lorent, Marine Kerleau, Clarisse Asberg, Anders Legendre, Christophe Morelon, Emmanuel Buron, Fanny Garrigue, Valérie Le Quintrec, Moglie Girerd, Sophie
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Background and objectives The fact that metabolism and immune function are regulated by an endogenous molecular clock that generates circadian rhythms suggests that the magnitude of ischemia reperfusion, and subsequent inflammation on kidney transplantation, could be affected by the time of the day. Design, setting, participants, & measurements We ...
Lai, Tengfang Shen, Yong Chen, Chengcai Huang, Bo Deng, Tongyuan Zhao, Zhuangzhi Zhang, Zhuohua Huang, Zhaohe Pan, Xingshou
Published in
European journal of pharmacology
The purpose of this study was to investigate the role of glycyrrhizic acid (GA) in regulating myocardial ischemia-reperfusion injury (MIRI) in rats as well as the underlying mechanism. H9c2 cells were subjected to hypoxia/re-oxygenation (H/R) to mimic the MIRI in vitro, while a rat model of ischemia-reperfusion (I/R) was constructed by occlusion of...
Watanabe, M. Borges, F.T. Pessoa, E.A. Fonseca, C.D. Fernandes, S.M. Drew, R.C. Volpini, R.A. Vattimo, M.F.F.
Published in
Brazilian Journal of Medical and Biological Research
Acute kidney injury (AKI) is a common complication in seriously ill patients, while renal ischemia-reperfusion (I/R) injury is the most frequent event in this oxidative renal injury. N-acetylcysteine (NAC) is a small molecule containing a thiol group that has antioxidant properties, promoting detoxification and acting directly as a free radical sca...
Park, Jong Mok Shin, Ju Hyun Yang, Seung Woo Lee, Ji Yong Lee, Chung Lyul Lim, Jae Sung Song, Ki Hak Kim, Gun Hwa Na, Yong Gil
Published in
International Neurourology Journal
Purpose Although metformin and sildenafil can protect various organs against ischemia/reperfusion (I/R) injuries, their effects and mechanisms of action in bladder I/R injuries remain unknown. This study investigated the effects and mechanisms of action of metformin and sildenafil against bladder I/R insults in rats. Methods One hundred male Spragu...
Ahadi, Sahar Zargari, Mehryar Khalatbary, Ali Reza
Published in
The journal of spinal cord medicine
Objective: Paraplegia or paraparesis due to spinal cord ischemia is one of the complications following thoracoabdominal aortic surgery. Recent studies revealed the neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on a variety of neurological disorders. The purpose of this study was to determine the neuroprotective effects of EGCG fo...
