Fahmy, Ebtesam Mohammed El Awady, Mohammed Ahmed El Sayed Sharaf, Sahar Abdel-Atty Selim, Nora Mahmoud Abdo, Hazem El Sawy Mohammed, Shaimaa Shaheen
Published in
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
BackgroundApolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim of this study is to assess the relation between apolipoprotien A1 and B and their ratio to intra- and extracranial carotid atheros...
Sharma, Vijay K Chou, Ning Sinha, Arvind K
Published in
British journal of neurosurgery
Background: Intracranial arterial stenosis is a common cause of ischemic stroke. Recent attempts with intracranial stenting and superficial temporal-middle cerebral artery (STA-MCA) bypass failed to show benefit. Perhaps, better strategies are needed for selecting suitable patients. Acetazolamide-challenged single photon emission computed tomograph...
Patel, Pious D Vimalathas, Praveen Niu, Xinnan Shannon, Chevis N Denny, Joshua C Peterson, Josh F Chitale, Rohan V Fusco, Matthew R
Published in
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Intracranial atherosclerotic disease (ICAD) is responsible for 8-10% of acute ischemic strokes, and resistance to antiplatelet therapy is prevalent. CYP2C19 gene loss-of-function (up to 45% of patients) causes clopidogrel resistance. For patients with asymptomatic ICAD and ICAD characterized by transient ischemic attack (TIA), this study measures t...
Wu, Hongliang Song, Huiqun Dou, Lianwei Gao, Bo Pan, Yan Dong, Mei Chen, Qi Li, Jiazhen Song, Lixiang Liu, Chuanyu
...
Published in
BMC Neurology
BackgroundDual antiplatelet aggregation therapy leads to better outcomes in patients with carotid artery stenosis, intracranial artery stenosis, minor strokes, or transient ischaemic attacks. However, carriers of the CYP2C19 loss-of-function allele may not experience the desired effects. We attempted to increase the clopidogrel dose to determine wh...
Kang, Koung Mi Byun, Min Soo Lee, Jun Ho Yi, Dahyun Choi, Hye Jeong Lee, Eunjung Lee, Younghwa Lee, Jun-Young Kim, Yu Kyeong Sohn, Bo Kyung
...
Published in
Alzheimer's Research & Therapy
BackgroundTo clarify whether atherosclerosis of the carotid and intracranial arteries is related to Alzheimer’s disease (AD) pathology in vivo, we investigated the associations of carotid and intracranial artery stenosis with cerebral beta-amyloid (Aβ) deposition and neurodegeneration in middle- and old-aged individuals. Given different variations ...
Danyel, Leon Alexander Hadzibegovic, Sara Valdueza, Jose Manuel Tietze, Anna Fuchs, Simon Schreiber, Stephan J Connolly, Florian
Published in
Ultrasound in medicine & biology
Transcranial color-coded duplex sonography (TCCS) and computed tomography angiography (CTA) are widely used to identify intracranial stenoses (ISs). We assessed concordance of IS grading between TCCS and CTA and proposed new TCCS criteria for severe IS ≥70%. One hundred two stroke patients (70 ± 13 y) with TCCS-identified IS were included. TCCS and...
Scutelnic, Adrian Mordasini, Pasquale Bervini, David El-Koussy, Marwan Heldner, Mirjam R.
Published in
Current Treatment Options in Neurology
Purpose of reviewThis review addresses the current evidence of epidemiologic and therapeutic strategies in patients with intracranial atherosclerotic stenosis (ICAS).Recent findingsThere is a considerable number of patients with ICAS worldwide, especially in Asia. Modern neuroimaging techniques have improved assessment lately and they are providing...
Kadooka, Keisuke Hagenbuch, Niels Anagnostakou, Vania Valavanis, Anton Kulcsár, Zsolt
Published in
Journal of neuroradiology = Journal de neuroradiologie
Endovascular treatment is offered for symptomatic intracranial stenosis (ICS) when medical therapy fails. The purpose of this meta-analysis is to evaluate the risks and effectiveness of balloon angioplasty (BA) alone. Systematic review and meta-analysis of all available articles on BA for symptomatic ICS was conducted. Data was analyzed separately ...
Eldeeb, Mai A. Zaki, Amr S. Ashour, Samia Abdel Nasser, Azza El Bassiouny, Ahmed Abdulghani, Khaled O.
Published in
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
BackgroundThe apolipoprotein A1 level is recognized as a better indicator of cardiovascular disease than other cholesterol measures.ObjectivesTo assess the serum level of ApoA1 in acute stroke patients and correlate it with the degree of vessel stenosis, stroke severity, prognosis, and functional outcome.Patients and methodsWe prospectively include...
Wang, Yuting Liu, Xinke Wu, Xiao Degnan, Andrew J Malhotra, Ajay Zhu, Chengcheng
Published in
Atherosclerosis
Intracranial atherosclerotic plaque is associated with ischemic strokes without substantial stenosis, and needs better characterization. We aim to investigate the clinical significance of intracranial plaque without substantial stenosis by high resolution vessel wall MRI (vwMRI) through a systematic review of existing studies. Studies investigating...
