Batachari, Lakshmi Dai, Alyssa Troemel, Emily
Upon sensing viral RNA, mammalian RIG-I-like receptors (RLRs) activate downstream signals using caspase activation and recruitment domains (CARDs), which ultimately promote transcriptional immune responses that have been well studied. In contrast, the downstream signaling mechanisms for invertebrate RLRs are much less clear. For example, the Caenor...
Viragova, Sara Li, Dong Klein, Ophir D
Tissue regeneration after damage is generally thought to involve the mobilization of adult stem cells that divide and differentiate into progressively specialized progeny. However, recent studies indicate that tissue regeneration can be accompanied by reversion to a fetal-like state. During this process, cells at the injury site reactivate programs...
Sarmiento, Mario Bardan Gang, Spencer S van Oosten-Hawle, Patricija Troemel, Emily R
Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular intestinal infection and proteotoxic stress and that promotes improved survival upon heat shock (thermotolerance). Here, we show that CUL-6 promotes thermotolerance by tar...
Roussin, Léa Gry, Elisa Macaron, Mira Ribes, Sandy Monnoye, Magali Douard, Véronique Naudon, Laurent Rabot, Sylvie
Previous studies on germ-free (GF) animals have described altered anxiety-like and social behaviors together with dysregulations in brain serotonin (5-HT) metabolism. Alterations in circulating 5-HT levels and gut 5-HT metabolism have also been reported in GF mice. In this study, we conducted an integrative analysis of various behaviors as well as ...
Muylle, Ewout; Winkel, Nele Van De; Hennion, Ina; 156721; Dubois, Antoine; 148934; Thorrez, Lieven; 34791; Deferm, Nathalie P.; Pirenne, Jacques; 2174; Ceulemans, Laurens J.; 85588;
Failure to close the abdomen after intestinal or multivisceral transplantation (Tx) remains a frequently occurring problem. Two attractive reconstruction methods, especially in large abdominal wall defects, are full-thickness abdominal wall vascularized composite allograft (AW-VCA) and nonvascularized rectus fascia (NVRF) Tx. This review compares s...
Cil, Erdem Nikolayev, Denys
Ingestible and implantable antennas are widely used in current in-body bioelectronic devices. This paper aims to examine the behavior of magnitude and phase of the reflection coefficient of ingestible antennas in the gastrointestinal tract for the purpose of sensing and distinguishing the gastrointestinal tissues (stomach, small intestine, and larg...
Singh, Shalini Giron, Leila B Shaikh, Maliha W Shankaran, Shivanjali Engen, Phillip A Bogin, Zlata R Bambi, Simona A Goldman, Aaron R Azevedo, Joao L L C Orgaz, Lorena
...
Published in
Microbiome
People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associated comorbidities. The extent to which living with HIV - influe...
Hong, Julie S Shamim, Abrar Atta, Hussein Nonnecke, Eric B Merl, Sarah Patwardhan, Satyajit Manell, Elin Gunes, Esad Jordache, Philip Chen, Bryan
...
Intestinal transplantation is the definitive treatment for intestinal failure. However, tissue rejection and graft-versus-host disease are relatively common complications, necessitating aggressive immunosuppression that can itself pose further complications. Tracking intraluminal markers in ileal effluent from standard ileostomies may present a non...
Fernandez, Adrian M Jones, Charles P Patel, Hiren V Ghaffar, Umar Hakam, Nizar Li, Kevin D Nabavizadeh, Behnam Breyer, Benjamin N
ObjectiveTo characterize adverse events related to use of the perirectal spacing agent SpaceOAR, we examined the Manufacturer and User Facility Device Experience (MAUDE) database.MethodsThe MAUDE database was queried for "SpaceOAR" and "Augmenix" from June 2015 (when SpaceOAR was approved by the Food and Drug Administration) to October 2022. Report...
Sharma, Aditi Achi, Sajan Chandrangadhan Ibeawuchi, Stella-Rita Anandachar, Mahitha Shree Gementera, Hobie Chaudhury, Uddeep Usmani, Fatima Vega, Kevin Sayed, Ibrahim M Das, Soumita
...
Microbial sensors play an essential role in maintaining cellular homoeostasis. Our knowledge is limited on how microbial sensing helps in differential immune response and its link to inflammatory diseases. Recently we have confirmed that ELMO1 (Engulfment and Cell Motility Protein-1) present in cytosol is involved in pathogen sensing, engulfment, a...