Soriano-Lerma, Ana García-Burgos, María Barton, Wiley Alférez, María José M Crespo-Pérez, Jorge Valentín Soriano, Miguel López-Aliaga, Inmaculada Cotter, Paul D García-Salcedo, José A
Published in
Biomedical journal
Iron deficiency is the top leading cause of anaemia, whose treatment has been shown to deteriorate gut health. However, a comprehensive analysis of the intestinal barrier and the gut microbiome during iron deficiency anemia (IDA) has not been performed to date. This study aims to delve further into the analysis of these two aspects, which will mean...
Wu, Shijing Hu, Li Fu, Yiwei Chen, Yating Hu, Zhibin Li, Huiliang Liu, Zhou
Published in
Molecular neurobiology
Intestinal microfold cells (M cells) play a critical role in the immune response of the intestinal mucosa by actively taking up antigens, facilitating antigen presentation to immune cells, and promoting the production of secretory immunoglobulin A by B cells. Despite their known important functions in the gut, the effect of M cells on the central n...
Gao, Zhao Gong, Zhiyuan Huang, Hai Ren, Xuemeng Li, Zhenlu Gao, Peng
Published in
Gene
The aim is to analyze differentially expressed genes (DEGs) in mice with sepsis-related intestinal mucosal barrier damage and to explore the diagnostic and protective mechanisms of this condition at the transcriptome level. Small intestinal tissues from healthy male C57BL/6J mice subjected to Cecal ligation and puncture (CLP) and sham operation wer...
Hu, Dan Yang, Xiaoran Qin, Ming Pan, Li'an Fang, Haiyan Chen, Pengnan Ni, Yingdong
Published in
Journal of animal science and biotechnology
Salmonella Typhimurium (S. Typhimurium) is a common pathogenic microorganism and poses a threat to the efficiency of poultry farms. As signaling molecules regulating the interaction between the host and gut microbiota, bile acids (BAs) play a protective role in maintaining gut homeostasis. However, the antibacterial effect of BAs on Salmonella infe...
Sánchez, Victor Baumann, Anja Kromm, Franziska Yergaliyev, Timur Brandt, Annette Scholda, Julia Kopp, Florian Camarinha-Silva, Amélia Bergheim, Ina
Published in
Molecular medicine (Cambridge, Mass.)
Chronic alcohol intake is associated with alterations of choline metabolism in various tissues. Here, we assessed if an oral choline supplementation attenuated the development of alcohol-related liver disease (ALD) in mice. Female C57BL/6 J mice (n = 8/group) were either pair-fed a liquid control diet, or a Lieber DeCarli liquid diet (5% ethanol) ±...
Zhu, Wei Cremonini, Eleonora Mastaloudis, Angela Oteiza, Patricia
Intestinal permeabilization is central to the pathophysiology of chronic gut inflammation. This study investigated the efficacy of glucoraphanin (GR), prevalent in cruciferous vegetables, particularly broccoli, and its derivative sulforaphane (SF), in inhibiting tumor necrosis factor alpha (TNFα)-induced Caco-2 cell monolayers inflammation and perm...
Casale, Eva Malaisé, Yann Cartier, Christel You, Teraihere Dupont, Sarah Houdeau, Eric Lamas, Bruno
Nanoparticles (NPs) can cross gut barrier, interact with immune cells and alter gut microbiota with health concerns. Kocide 3000® (K3) is a copper (Cu(OH2))-based nanopesticide, but the intestinal effects of Cu-NPs compared to Cu-based conventional (non-nano) pesticide have not received attention. We aim to evaluate in mice the impact of K3 exposur...
Zhang, Changxi Yin, Zhicheng Hu, Feng'ai Lin, Xutao Guan, Qinghai Zhang, Fan Zhang, Xingyuan
Published in
Molecular biotechnology
Obstructive jaundice (OJ) can cause multiple pathophysiological consequences including intestinal barrier dysfunction. Omega-3 has been indicated to have a promising therapeutic effect on OJ. This study aimed to further investigate the functions of omega-3 on OJ-induced intestinal injury. A rat OJ model was established by bile duct ligation with or...
Simbrunner, Benedikt Hofer, Benedikt S Schwabl, Philipp Zinober, Kerstin Petrenko, Oleksandr Fuchs, Claudia Semmler, Georg Marculescu, Rodrig Mandorfer, Mattias Datz, Christian
...
Published in
Hepatology international
Experimental studies linked dysfunctional Farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling to liver disease. This study investigated key intersections of the FXR-FGF19 pathway along the gut-liver axis and their link to disease severity in patients with cirrhosis. Patients with cirrhosis undergoing hepatic venous pressure gra...
Wu, Hao Lou, Tianyu Pan, Mingxia Wei, Zuying Yang, Xiaoqin Liu, Lirong Feng, Menghan Shi, Lixia Qu, Biqiong Cong, Shiyu
...
Published in
Journal of ethnopharmacology
Nonalcoholic steatohepatitis (NASH) is a prominent cause of liver-related death that poses a threat to global health and is characterized by severe hepatic steatosis, lobular inflammation, and ballooning degeneration. To date, no Food and Drug Administration-approved medicine is commercially available. The Chaihu Guizhi Ganjiang Decoction (CGGD) sh...
