Majumder, Debabrata Debnath, Rahul Maiti, Debasish
Published in
Life sciences
The major cause behind lung cancer development is exposure to various polycyclic aromatic hydrocarbons like benzo(a)pyrene (BaP) present in tobacco smoke, motor vehicle, and industrial exhaust. BaP is reported to induce the expression of various pro-inflammatory cytokines and matrix remodeling proteins. It is also responsible for dysfunction and ex...
Sakhaee, Fatemeh Ghazanfari, Morteza Vaziri, Farzam Jamnani, Fatemeh Rahimi Davari, Mehdi Gharibzadeh, Safoora Fateh, Roohollah Abdolrahimi, Farid Dizaji, Shahin Pourazar Fateh, Abolfazl
...
Published in
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B), interferon lambda 4 (IFNL4) and the human leukocyte antigen (HLA) gene are associated with treatment responses in patients with chronic hepatitis C (CHC) virus infection treated with pegylated interferon-α and ribavirin (pegIFN-α/RBV). We compared the role of IL28B SNPs (rs129...
Jia, Y T Duan, X H Yang, Z X Su, Y H
Published in
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Tamai, Hideyuki Ida, Yoshiyuki Kawashima, Akira Shingaki, Naoki Shimizu, Ryo Moribata, Kosaku Nasu, Tetsushi Maekita, Takao Iguchi, Mikitaka Kato, Jun
...
Published in
Gut and liver
Simeprevir-based triple therapy with reduced doses of PEG-IFN and ribavirin was safe and effective for IFN ineligible patients infected with genotype 1b HCV. IL28B polymorphism status was a useful predictor of the SVR.
de la Fuente, Sara Citores, María-Jesús Duca, Ana Cisneros, Elisa Baños, Isolina Vilches, Carlos Cuervas-Mons, Valentín
Published in
Clinical and Experimental Medicine
Persistent hepatitis C virus (HCV) infection is associated with progressive hepatic fibrosis and ultimately hepatocellular carcinoma. The interleukin-28B (IL28B) rs12979860 polymorphism is associated with fibrosis progression in chronic HCV infection. IL28B encodes interferon-λ, which has both antiviral and anti-proliferative properties. This study...
Kanda, Tatsuo Nakamoto, Shingo Yokosuka, Osamu
Published in
World journal of virology
In 2009, several groups reported that interleukin-28B (IL28B) genotypes are associated with the response to peginterferon plus ribavirin therapy for chronic hepatitis C virus (HCV) infection in a genome-wide association study, although the mechanism of this association is not yet well understood. However, in recent years, tremendous progress has be...
Huang, Chung-Feng Huang, Ching-I Yeh, Ming-Lun Huang, Jee-Fu Hsieh, Ming-Yen Lin, Zu-Yau Chen, Shinn-Cherng Yu, Ming-Lung Dai, Chia-Yen Chuang, Wan-Long
...
Published in
The Kaohsiung journal of medical sciences
The prevalence and characteristics of patients with hepatitis C virus mixed genotype 1 and 2 infection (HCV-1/2) remains unclear. For each HCV-1/2 patient with histological data available, two age- and sex-matched HCV-1 and HCV-2 infected patients were selected for comparison, respectively. Of the 2776 patients, 261 (9.4%) patients were identified ...
Hu, Ching-Chih Lin, Chih-Lang Chang, Liang-Che Chien, Cheng-Hung Chen, Li-Wei Liu, Ching-Jung Chien, Rong-Nan
Published in
BMC Infectious Diseases
BackgroundThe role of single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B in predicting therapeutic response of pegylated interferon (peg-IFN) plus ribavirin (PR) for genotype 1 infected chronic hepatitis C patients with advanced fibrosis (AF) is limited. The aim of this study is to assess its role in predicting sustained virologic respo...
Akkarathamrongsin, Srunthron Payungporn, Sunchai Thong, Vo Duy Poovorawan, Kittiyod Prapunwattana, Phisit Poovorawan, Yong Tangkijvanich, Pisit
Published in
World journal of gastroenterology
The IL28B genotype was linked to an impact on early viral kinetics in response to PEG-IFN/RBV therapy in HCV-6 infected patients.
Mi, Yin Gao, Ying Tang Jiao, Xiao Lei Guo, Hua Liu, Tong Jing, Li Shi, Wen Xia Du, Zhi
Published in
Hepatitis monthly
Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) rs8099917 has been described to be associated with response to treatment with pegylated interferon and ribavirin (PEG-IFN/RBV) in patients with chronic hepatitis C from the North America, Europe, Asia countries like Japan and Taiwan. Whether this holds true for Chinese patients remains un...
