Published in BMC Research Notes
ObjectivesIL17 is a critical pro-inflammatory cytokine that is involved in inflammation, multidrug resistance and growth persistence pathways in cancer. This study is aiming at studying the expression of IL17 and hormonal receptors expression in benign and malignant breast lesions using immunohistochemical staining methods.ResultsA total of 137 cas...
Published in Current Rheumatology Reports
Purpose of the ReviewReactive arthritis is synovitis related to an infection away from the joint. The evolution is variable, frequently self-limited, but with the possible evolution to a prolonged form, generating functional incapacity and sequelae.Recent FindingsNew microbiological families have been incriminated and pathophysiological links have ...
Published in Cell & Bioscience
BackgroundInterleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment was often associated with poor prognosis and reduced cytotoxic T cell infiltration. These contradictory phenomena suggest that IL-17...
Published in BMC Rheumatology
BackgroundOsteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim of this study was to characterize an IL-17-me...
Published in Journal of Translational Medicine
BackgroundSjögren’s syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary destruction and dysfunctional glandular secretion. Metabolic syndrome influences the immune system. To investigate its relationship with metabolic abnormalities, we evaluated the pathog...
Published in Immune Network
IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor imm...
Published in Aquaculture (Amsterdam, Netherlands)
• IL-17AF1, IL-17AF2, and IL-17AF3 exerted an antiviral effect by activating the NF-κB signaling pathway. • The expression levels of IL-17AF1, IL-17AF2, IL-17AF3 gradually increased after GCRV infection. • The nuclear translocation of p65 in CIK cells gradually increased after GCRV infection. • Overexpression of IL-17AF1, IL-17AF2, or IL-17AF3 prom...
Published in World Journal of Clinical Cases
BACKGROUND As one of the subsets of CD8+ T cells, Tc17 cells have recently been identified and are characterized by the secretion of interleukin (IL)-17, which is related to inflammatory diseases. AIM To assess the status of Tc17 cells in cervical cancer and investigate the biological function of Tc17 cells in cervical cancer development. METHODS F...
Published in Cytokine
Rheumatoid Arthritis (RA) is an autoimmune systemic disease and in its pathogenesis participate several proinflammatory cytokines, including those produced by Th17 cells. We performed a systematic review aiming to assess the associations between polymorphisms in Th17 cytokines, namely IL-17A, IL-17F, IL-21 and IL-22, and susceptibility to RA. We se...
