Liu, Suling Cui, Yang Zhang, Xiao
Published in
Clinical rheumatology
Iguratimod (IGU) is a novel small molecule anti-rheumatic drug with the effect of non-steroidal anti-inflammatory drug and disease-modifying anti-rheumatic drug. IGU has various mechanisms of action, including inhibition of prostaglandin E2, tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17) production, inhibition of macrophage migration inhib...
Álvarez-Coiradas, Elia Munteanu, Cristian R Díaz-Sáez, Laura Pazos, Alejandro Huber, Kilian V M Loza, María Isabel Domínguez, Eduardo
Published in
International immunopharmacology
Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioavailability. Thus, it is necess...
Keryakos, Hesham Kamal Habeeb Mohammed, Ahmed Ali Higazi, Aliaa Monir Mahmoud, Esraa Abdel Magid Saad, Zienab Mostafa
Published in
Current research in translational medicine
Spontaneous bacterial peritonitis (SBP) is a potentially lethal complication of ascites. The inflammatory response is very intense in case of SBP despite low concentration of bacteria in the ascitic fluid with IL-17A overproduced by intestinal Paneth cells and may have role in host immune defense and inflammatory response. To study the diagnostic p...
Soytürk, Hayriye Yılmaz, Murat
SUMMARY OBJECTIVE: The role of interleukins, such as IL-17 and IL-34, in the pathogenesis of autoimmune diseases has been established in the literature. In the current study, we aimed to identify the concentrations of IL-17 (IL-17A, IL-17F) and IL-34 in the cerebrospinal fluid (CSF) of patients with chronic inflammatory demyelinating polyneuropathy...
Timganova, Valeria P. Zamorina, Svetlana A. Litvinova, Larisa S. Todosenko, Natalia M. Bochkova, Maria S. Khramtsov, Pavel V. Rayev, Mikhail B.
Published in
BMC Immunology
BackgroundPregnancy-specific β1-glycoproteins are capable of regulating innate and adaptive immunity, exerting predominantly suppressive effects. In this regard, they are of interest in terms of their pharmacological potential for the treatment of autoimmune diseases and post-transplant complications. The effect of these proteins on the main pro-in...
Batah, Sabrina Setembre Alda, Maiara Almeida Rodrigues Lopes Roslindo Figueira, Rebec... Cruvinel, Heloisa R. Perdoná Rodrigues da Silva, Luis Machado-Rugolo, Juliana Velosa, Ana Paula Teodoro, Walcy Rosolia Balancin, Marcelo Silva, Pedro Leme
...
Published in
Pathobiology
Several studies have reported the pathophysiologic and molecular mechanisms responsible for pulmonary arterial hypertension (PAH). However, the in situ evidence of collagen V (Col V) and interleukin-17 (IL-17)/interleukin-6 (IL-6) activation in PAH has not been fully elucidated. We analyzed the effects of collagen I (Col I), Col V, IL-6, and IL-17 ...
Coskun Benlidayi, Ilke Kurtaran, Behice Tirasci, Emre Guzel, Rengin
Published in
Rheumatology international
Severe acute respiratory syndrome coranovirus-2 (SARS-CoV-2) infection has become an important health-care issue worldwide. The coronavirus disease 2019 (COVID-19) has also raised concerns among patients with inflammatory rheumatic conditions and their treating physicians. There are emerging data regarding the potential risks of SARS-CoV-2 for this...
Rafael-Vidal, Carlos Pérez, Nair Altabás, Irene Garcia, Samuel Pego-Reigosa, Jose M.
Published in
International Journal of Molecular Sciences
Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that affect the connective tissue, characterized by the involvement of multiple organs, leading to disability, organ failure and premature mortality. Despite the advances in recent years, the therapeutic options for these diseases are still limited and some patients do no...
Saxena, Somil Venugopal, Ranganath Chandrayan Rao, Rachana Yuwanati, Monal B. Awasthi, Harshita Jain, Megha
Published in
Journal of Oral Biology and Craniofacial Research
Purpose Chronic periodontitis (CP) and Type 2 diabetes mellitus (T2DM) are chronic diseases affecting the humans and have interrelationship in their pathogenesis. Monitoring the progress with biomarker in these disease is important from treatment outcome point of view. We investigated the association of salivary developmental endothelial locus-1 (D...
Senterre, Yseult Jouret, Gaëlle Collins, Patrick Nikkels, Arjen F
Published in
Dermatology and therapy
Risankizumab, an interleukin (IL)-23 antagonist, is a highly effective treatment for moderate to severe psoriasis. Crusted scabies (CS) is a rare and severe form of scabies, occurring mainly in immunosuppressed patients and/or neurologically or mentally ill patients. A young girl with Down syndrome was diagnosed with a hyperkeratotic form of psoria...