Rashidian, Houman Subramaniapillai, Mehala Park, Caroline Lipsitz, Orly Zuckerman, Hannah Teopiz, Kayla Cao, Bing Lee, Yena Gill, Hartej Ho, Roger
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Published in
Journal of affective disorders
To assess the effect of insulin resistance (IR) on treatment response to the antidepressant, vortioxetine, in patients with Major Depressive Disorder (MDD). This is a secondary analysis of an 8-week, open-label clinical trial. Ninety-five adults in a primary care setting experiencing a major depressive episode were included. Response to vortioxetin...
Santos, Andrey Magro, Daniéla Oliveira Evangelista-Poderoso, Rosana Saad, Mario José Abdalla
Published in
Diabetology & metabolic syndrome
Our understanding of the pathophysiology of the COVID-19 manifestations and evolution has improved over the past 10 months, but the reasons why evolution is more severe in obese and diabetic patients are not yet completely understood. In the present review we discuss the different mechanisms that may contribute to explain the pathophysiology of COV...
Wendland, Natalia Opydo-Szymaczek, Justyna Mizgier, Małgorzata Jarząbek-Bielecka, Grażyna
Published in
Clinical oral investigations
Research studies suggest that polycystic ovary syndrome (PCOS) may influence the composition of the oral microflora in women. This study aimed to investigate factors affecting the number of selected periopathogens in a young cohort of females with PCOS and to assess the association between oral hygiene, subgingival microbiome, gingival health, and ...
Heiskanen, Marja A. Honkala, Sanna M. Hentilä, Jaakko Ojala, Ronja Lautamäki, Riikka Koskensalo, Kalle Lietzén, Martin S. Saunavaara, Virva Saunavaara, Jani Helmiö, Mika
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Published in
BMC Sports Science, Medicine and Rehabilitation
Background Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between the central nervous system, peripheral tissues, and gut microbiota, and is affected by genetics. Systemic cross-talk between brai...
Wang, Anxin Wang, Guangyao Liu, Qian Zuo, Yingting Chen, Shuohua Tao, Boni Tian, Xue Wang, Penglian Meng, Xia Wu, Shouling
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Published in
Cardiovascular Diabetology
Background Triglyceride-glucose (TyG) index was recently suggested to be a reliable surrogate marker of insulin resistance. We aim to investigate the associations between baseline and long-term TyG index with subsequent stroke and its subtypes in a community-based cohort. Methods A total of 97,653 participants free of history of stroke in the Kailu...
Deehan, Edward C. Colin-Ramirez, Eloisa Triador, Lucila Madsen, Karen L. Prado, Carla M. Field, Catherine J. Ball, Geoff D. C. Tan, Qiming Orsso, Camila Dinu, Irina
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Published in
Trials
Background Accumulating evidence suggests that the metabolic effects of metformin and fermentable fibers are mediated, in part, through diverging or overlapping effects on the composition and metabolic functions of the gut microbiome. Pre-clinical animal models have established that the addition of fiber to metformin monotherapy improves glucose to...
Femminella, Grazia Daniela Livingston, Nicholas R. Raza, Sanara van der Doef, Thalia Frangou, Eleni Love, Sharon Busza, Gail Calsolaro, Valeria Carver, Stefan Holmes, Clive
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Published in
Alzheimer's Research & Therapy
Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated the influence of insulin resistance on brain glucose metabolism, grey matter volume and white matter ...
Spritzer, Poli Mara Ramos, Ramon Bossardi Marchesan, Lucas Bandeira de Oliveira, Monica Carmina, Enrico
Published in
Diabetology & Metabolic Syndrome
Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regar...
Lindåse, Sanna Nostell, Katarina Bergsten, Peter Forslund, Anders Bröjer, Johan
Published in
BMC Veterinary Research
Background Proxies are mathematical calculations based on fasting glucose and/or insulin concentrations developed to allow prediction of insulin sensitivity (IS) and β-cell response. These proxies have not been evaluated in horses with insulin dysregulation. The first objective of this study was to evaluate how fasting insulin (FI) and proxies for ...
Sidsworth, Danielle A. Sellers, Stephanie L. Reutens-Hernandez, Jennifer P. Dunn, Elizabeth A. Gray, Sarah L. Payne, Geoffrey W.
Published in
Heliyon
Diet-induced obesity, Insulin resistance, Microvascular function, Sex-differences.
