Hattori, Sachiko
Published in
Diabetology & Metabolic Syndrome
BackgroundOmarigliptin is a potent, selective, oral dipeptidyl peptidase 4 (DPP4) inhibitor with a half-life that allows weekly dosing. Inflammation or insulin resistance might be pathological mediators of cardiovascular events in patients with type 2 diabetes.MethodsWhether omarigliptin has anti-inflammatory effects that result in decreased levels...
Yahaya, Tajudeen O. Salisu, Titilola Abdulrahman, Yusuf B. Umar, Abdulrazak K.
Published in
Egyptian Journal of Medical Human Genetics
BackgroundMany studies have been conducted on the genetic and epigenetic etiology of gestational diabetes mellitus (GDM) in the last two decades because of the disease’s increasing prevalence and role in global diabetes mellitus (DM) explosion. An update on the genetic and epigenetic etiology of GDM then becomes imperative to better understand and ...
Won, Ki-Bum Park, Eun Ji Han, Donghee Lee, Ji Hyun Choi, Su-Yeon Chun, Eun Ju Park, Sung Hak Han, Hae-Won Sung, Jidong Jung, Hae Ok
...
Published in
Cardiovascular Diabetology
BackgroundData on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults.MethodsWe enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG ...
Pivonello, Claudia Muscogiuri, Giovanna Nardone, Antonio Garifalos, Francesco Provvisiero, Donatella Paola Verde, Nunzia de Angelis, Cristina Conforti, Alessandro Piscopo, Mariangela Auriemma, Renata Simona
...
Published in
Reproductive Biology and Endocrinology
Bisphenol-A (BPA) has been reported to be associated to female infertility. Indeed, BPA has been found to be more frequently detected in infertile women thus leading to hypothesize a possible effect of BPA on natural conception and spontaneous fecundity. In addition, in procedures of medically assisted reproduction BPA exposure has been found to be...
Dubey, Sunil Kumar Lakshmi, K K Krishna, Kowthavarapu Venkata Agrawal, Mukta Singhvi, Gautam Saha, Ranendra Narayana Saraf, Swarnalat Saraf, Shailendra Shukla, Rahul Alexander, Amit
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Published in
Life sciences
Alzheimer's disease, a progressive neurodegenerative disorder, is one of the leading causes of death in the USA, along with cancer and cardiac disorders. AD is characterized by various neurological factors like amyloid plaques, tau hyperphosphorylation, mitochondrial dysfunction, acetylcholine deficiency, etc. Together, impaired insulin signaling i...
Bidulescu, Aurelian Dinh, Paul C. Jr Sarwary, Shabir Forsyth, Emily Luetke, Maya C. King, David B. Liu, Jiankang Davis, Sharon K. Correa, Adolfo
Published in
BMC Endocrine Disorders
BackgroundGrowing evidence suggests that leptin is critical for glycemic control. Impaired leptin signaling may also contribute to low adiponectin expression in obese individuals. We assessed the association of leptin and adiponectin with incident type 2 diabetes (T2D), their interactions with sex and obesity status, and mediation by insulin resist...
jantrapirom, salinee nimlamool, wutigri chattipakorn, nipon chattipakorn, siriporn temviriyanukul, piya inthachat, woorawee govitrapong, piyarat potikanond, saranyapin
Neuronal insulin resistance is a significant feature of Alzheimer&rsquo / s disease (AD). Accumulated evidence has revealed the possible neuroprotective mechanisms of antidiabetic drugs in AD. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog and an antidiabetic agent, has a benefit in improving a peripheral insulin resistance. However, the neu...
Butler, Andrew A Graham, James L Stanhope, Kimber L Wong, So King, Sarah Bremer, Andrew A Krauss, Ronald M Hamilton, James Havel, Peter J
Angiopoietin-like protein 3 (ANGPTL3) inhibits lipid clearance and is a promising target for managing cardiovascular disease. Here we investigated the effects of a high-sugar (high-fructose) diet on circulating ANGPTL3 concentrations in rhesus macaques. Plasma ANGPTL3 concentrations increased ∼30% to 40% after 1 and 3 months of a high-fructose diet...
Cheng, Fangxiao Yuan, Geheng He, Jiao Shao, Yimin Zhang, Junqing Guo, Xiaohui
Published in
Diagnostic Pathology
BackgroundInsulin resistance (IR) in obesity is associated with the occurrence of metabolic and cardiovascular diseases. Dipepidyl peptidase 4 (DPP4) plays a pivotal role during the development of IR, and was found to be a target gene of microRNA-214 (miR-214) in our study. This study sought to assess the expression and clinical value of miR-214 in...
Seyama, Mariko Yoshida, Kaya Yoshida, Kayo Fujiwara, Natsumi Ono, Kisho Eguchi, Takanori Kawai, Hotaka Guo, Jiajie Weng, Yao Haoze, Yuan
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Published in
Biochimica et biophysica acta. Molecular basis of disease
Outer membrane vesicles (OMVs) are nanosized particles derived from the outer membrane of gram-negative bacteria. Oral bacterium Porphyromonas gingivalis (Pg) is known to be a major pathogen of periodontitis that contributes to the progression of periodontal disease by releasing OMVs. The effect of Pg OMVs on systemic diseases is still unknown. To ...
