Ajayi, Ebenezer I. O. Molehin, Olorunfemi R. Oloyede, Omotade I. Kumar, Vinod Amara, Venkateswara R. Kaur, Jasmine Karpe, Pinakin Tikoo, Kulbhushan
Published in
Clinical Phytoscience
BackgroundNon-alcoholic fatty liver disease, which occurs in people who are not alcohol drinkers, describes some of the pathogenic conditions that may be in the least characterized by simple steatosis or can be as serious as non-alcoholic steatohepatitis and cirrhosis. Its mechanistic pathogenesis has been said to arise from insulin resistance and ...
Lee, Ellen E Sears, Dorothy D Liu, Jinyuan Jin, Hua Tu, Xin M Eyler, Lisa T Jeste, Dilip V
BACKGROUND:Persons with schizophrenia and schizoaffective disorder (PwS) have high rates of cardiometabolic pathology that contributes to premature mortality. Adiponectin is a metabolic hormone affecting insulin sensitivity and inflammation, and is active in the brain. High-molecular weight (HMW) adiponectin is considered a more sensitive marker of...
Lewandowski, Krzysztof C. Dąbrowska, Katarzyna Brzozowska, Maria Kawalec, Joanna Lewiński, Andrzej
Published in
Diabetology & Metabolic Syndrome
BackgroundSHORT syndrome is an autosomal dominant condition associated severe insulin resistance (IR) and lipoatrophy due to post-receptor defect in insulin signaling involving phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), where no clear treatment guidelines are available.MethodsWe attempted to test the efficacy metformin in a female pat...
Chan, Yi-Hsin Chang, Gwo-Jyh Lai, Ying-Ju Chen, Wei-Jan Chang, Shang-Hung Hung, Li-Man Kuo, Chi-Tai Yeh, Yung-Hsin
Published in
Cardiovascular Diabetology
BackgroundInsulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear.MethodsWe investigated the corresponding mechanism in two IR models of rats fed 15-week high-fat (HFa) and high-fructose/cholesterol (HFr) diets. AF was evaluat...
Tao, Xin Cai, Lisi Chen, Lei Ge, Shuqi Deng, Xuanying
Published in
Journal of Ovarian Research
AimsThis study was designed to evaluate the protective effects of AMPKα and SIRT1 on insulin resistance in PCOS rats, and to illuminate the underlying mechanisms.MethodsAn in vitro PCOS model was established by DHEA (6 mg/(100 g•d)), and the rats were randomly divided into the metformin group (MF group, n = 11), the exenatide group (EX group, n = 1...
Yu, Hairong Wang, Tao Zhang, Rong Yan, Jing Jiang, Feng Li, Shanshan Jia, Weiping Hu, Cheng
Published in
Nutrition & Metabolism
BackgroundBoth genetic and lifestyle factors contribute to the incidence of type 2 diabetes. It yet remains controversial whether and how alcohol consumption, one of the most prevalent lifestyle habits, influences type 2 diabetes. Moreover, whether alcohol consumption interacts with genetic risk is inconclusive. Thus, we aimed to explore the effect...
Sacerdote, Alan Dave, Paulomi Lokshin, Vladimir Bahtiyar, Gül
Published in
Current Diabetes Reports
Purpose of ReviewThere is a growing, largely inconsistent, literature on the role of vitamin D in association with type 2 diabetes, insulin resistance/insulin secretion, glycemic indices, and complications of type 2 diabetes. Pathophysiologic, bystander, preventive, and treatment roles of vitamin D have all been proposed. In this focused review, we...
Lankatillake, Chintha Huynh, Tien Dias, Daniel A.
Published in
Plant Methods
Type 2 Diabetes Mellitus has reached epidemic proportions as a result of over-nutrition and increasingly sedentary lifestyles. Current therapies, although effective, are not without limitations. These limitations, the alarming increase in the prevalence of diabetes, and the soaring cost of managing diabetes and its complications underscores an urge...
Holt, Richard I. G.
Published in
Current Diabetes Reports
Purpose of ReviewThe prevalence of diabetes is 2–3-fold higher in people with severe mental illness than the general population. There are concerns that antipsychotics increase the risk of diabetes. This review will examine the latest epidemiological studies linking antipsychotics and diabetes, as well as the mechanisms underlying the association a...
Yue, Wenzhu Sun, Xingxing Du, Tingting
Published in
BMC Endocrine Disorders
BackgroundCholecystectomy, central obesity, and insulin resistance (IR) are established risk factors for nonalcoholic fatty liver disease (NAFLD). We aimed to examine the relative contributions and combined association of cholecystectomy and central obesity/IR with NAFLD risk.MethodsWe conducted a cross-sectional analysis of data from the third Nat...
