Bogdanow, Boris
All viruses hijack host cells to replicate. To this end, they have to interact with cellular factors at all stages of the replication cycle. Since these host cell factors differ markedly between species, viruses typically need to adapt in order to cross a species barrier. Advances in high-throughput sequencing have provided insights into the extrao...
Behillil, Sylvie May, Faten Fourati, Slim Luyt, Charles-Edouard Chicheportiche, Thomas Sonneville, Romain Tandjaoui-Lambiotte, Yacine Roux, Damien Guérin, Laurent Mayaux, Julien
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Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others ...
Hong, Eun-Hye Song, Jae-Hyoung Kim, Seong-Ryeol Cho, Jaewon Jeong, Birang Yang, Heejung Jeong, Jae-Hyeon Ahn, Jae-Hee Jeong, Hyunjin Kim, Seong-Eun
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Published in
Immune network
Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of choice for treating patients with influenza virus infection. However, recent emergence of oseltamivir-resistant influenza viruses has limited its efficacy. Morin hydr...
Gostic, Katelyn M Bridge, Rebecca Brady, Shane Viboud, Cécile Worobey, Michael Lloyd-Smith, James O
Across decades of co-circulation in humans, influenza A subtypes H1N1 and H3N2 have caused seasonal epidemics characterized by different age distributions of cases and mortality. H3N2 causes the majority of severe, clinically attended cases in high-risk elderly cohorts, and the majority of overall deaths, whereas H1N1 causes fewer deaths overall, a...
Bangaru, Sandhya Lang, Shanshan Schotsaert, Michael Vanderven, Hillary A Zhu, Xueyong Kose, Nurgun Bombardi, Robin Finn, Jessica A Kent, Stephen J Gilchuk, Pavlo
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Published in
Cell
Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epitope in the HA trimer interface, suggesting previous...
Choi, Jang-Gi Lee, Heeeun Kim, Young Soo Hwang, Youn-Hwan Oh, You-Chang Lee, Bonggi Moon, Kyoung Mi Cho, Won-Kyung Ma, Jin Yeul
Published in
The American journal of Chinese medicine
Aloe vera ethanol extract (AVE) reportedly has significant anti-influenza virus activity, but its underlying mechanisms of action and constituents have not yet been completely elucidated. Previously, we have confirmed that AVE treatment significantly reduces the viral replication of green fluorescent protein-labeled influenza A virus in Madin-Darby...
Lefeuvre, Caroline Behillil, Sylvie Triau, Stéphane Monteiro-Rodrigues, Antonio Templier, François Tran, Cong Tri Le Guillou-Guillemette, Hélène Lunel-Fabiani, Françoise Enouf, Vincent Ducancelle, Alexandra
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Published in
The American journal of case reports
BACKGROUND Influenza viruses induce uncomplicated infections in most cases in individuals with no known predisposing factors. Acute febrile illness is generally limited to upper respiratory symptoms and several constitutional symptoms, including headache, lethargy, and myalgia. However, influenza A virus is a cause of severe morbidity and mortality...
Busignies, V. Simon, G. Mollereau, G. Bourry, O. Mazel, V. Rosa-Calatrava, Manuel Tchoreloff, P.
Liquid vaccine formulations present some disadvantages such as stability problems, cold chain requirement or administration by trained personnel. Vaccine formulated as tablets would present a wide range of progress such as an increase stability that would facilitate the administration, the distribution and the storage of vaccine formulations. This ...
Gagnon, Alain Acosta, Enrique Hallman, Stacey Bourbeau, Robert Dillon, Lisa Y Ouellette, Nadine Earn, David JD Herring, D Ann Inwood, Kris Madrenas, Joaquin
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Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immu...
Cybis, Gabriela B Sinsheimer, Janet S Bedford, Trevor Rambaut, Andrew Lemey, Philippe Suchard, Marc A
Influenza is responsible for up to 500,000 deaths every year, and antigenic variability represents much of its epidemiological burden. To visualize antigenic differences across many viral strains, antigenic cartography methods use multidimensional scaling on binding assay data to map influenza antigenicity onto a low-dimensional space. Analysis of ...