Burnett, Cassandra E Okholm, Trine Line Hauge Tenvooren, Iliana Marquez, Diana M Tamaki, Stanley Munoz Sandoval, Priscila Willmore, Andrew consortium, ucsf comet Hendrickson, Carolyn M Kangelaris, Kirsten N
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While studies have elucidated many pathophysiological elements of COVID-19, little is known about immunological changes during COVID-19 resolution. We analyzed immune cells and phosphorylated signaling states at single-cell resolution from longitudinal blood samples of patients hospitalized with COVID-19, pneumonia and/or sepsis, and healthy indivi...
Luo, Zhenlong Ji, Yudong Zhang, Dinghong Gao, Hong Jin, Zhongmou Yang, Meixiang Ying, Wei
AimLow-grade inflammation is the hallmark of non-alcoholic fatty liver diseases (NAFLD) and non-alcoholic steatohepatitis (NASH). The leakage of microbiota-derived products can contribute to liver inflammation during NAFLD/NASH development. Here, we assessed the roles of gut microbial DNA-containing extracellular vesicles (mEVs) in regulating liver...
Vital, Edward M Merrill, Joan T Morand, Eric F Furie, Richard A Bruce, Ian N Tanaka, Yoshiya Manzi, Susan Kalunian, Kenneth C Kalyani, Rubana N Streicher, Katie
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ObjectivesTo characterise the efficacy and safety of anifrolumab in patients with systemic lupus erythematosus (SLE) according to interferon gene signature (IFNGS), demographic and clinical subgroups.MethodsWe performed post hoc analyses of pooled data from the 52-week phase III TULIP-1/TULIP-2 placebo-controlled trials of intravenous anifrolumab i...
Rahimi, Rod A Cho, Josalyn L Jakubzick, Claudia V Khader, Shabaana A Lambrecht, Bart N Lloyd, Clare M Molofsky, Ari B Talbot, Sebastien Bonham, Catherine A Drake, Wonder P
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The mammalian airways and lungs are exposed to a myriad of inhaled particulate matter, allergens, and pathogens. The immune system plays an essential role in protecting the host from respiratory pathogens, but a dysregulated immune response during respiratory infection can impair pathogen clearance and lead to immunopathology. Furthermore, inapprop...
Mick, Eran Tsitsiklis, Alexandra Spottiswoode, Natasha Caldera, Saharai Serpa, Paula Hayakawa Detweiler, Angela M Neff, Norma Pisco, Angela Oliveira Li, Lucy M Retallack, Hanna
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Unlike other respiratory viruses, SARS-CoV-2 disproportionately causes severe disease in older adults whereas disease burden in children is lower. To investigate whether differences in the upper airway immune response may contribute to this disparity, we compare nasopharyngeal gene expression in 83 children (40-years-old; 45 with SARS-CoV-2, 28 wit...
Bruce, Ian N Furie, Richard A Morand, Eric F Manzi, Susan Tanaka, Yoshiya Kalunian, Kenneth C Merrill, Joan T Puzio, Patricia Maho, Emmanuelle Kleoudis, Christi
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ObjectivesIn the anifrolumab systemic lupus erythematosus (SLE) trial programme, there was one trial (TULIP-1) in which BILAG-based Composite Lupus Assessment (BICLA) responses favoured anifrolumab over placebo, but the SLE Responder Index (SRI(4)) treatment difference was not significant. We investigated the degree of concordance between BICLA and...
Ugarte-Gil, Manuel Francisco Alarcón, Graciela S Izadi, Zara Duarte-García, Ali Reátegui-Sokolova, Cristina Clarke, Ann Elaine Wise, Leanna Pons-Estel, Guillermo J Santos, Maria Jose Bernatsky, Sasha
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AimTo determine characteristics associated with more severe outcomes in a global registry of people with systemic lupus erythematosus (SLE) and COVID-19.MethodsPeople with SLE and COVID-19 reported in the COVID-19 Global Rheumatology Alliance registry from March 2020 to June 2021 were included. The ordinal outcome was defined as: (1) not hospitalis...
Sureshchandra, Suhas Zulu, Michael Z Doratt, Brianna M Jankeel, Allen Tifrea, Delia Edwards, Robert Rincon, Monica Marshall, Nicole E Messaoudi, Ilhem
While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild dis...
Agrawal, Sudhanshu Baulch, Janet E Madan, Shreya Salah, Seher Cheeks, Samantha N Krattli, Robert P Subramanian, Veedamali S Acharya, Munjal M Agrawal, Anshu
Alzheimer's disease (AD) is associated with dysregulated immune and inflammatory responses. Emerging evidence indicates that peripheral immune activation is linked to neuroinflammation and AD pathogenesis. The present study focuses on determining the role of IL-21 in the pathogenesis of AD using human samples and the 5xFAD mice model. We find that ...
Guo, Xingyi Dang, Weiyu Li, Na Wang, Ying Sun, Deming Nian, Hong Wei, Ruihua
PurposeTo investigate the effects and mechanisms of fenofibrate, a synthetic ligand of peroxisome proliferator-activated receptor α (PPAR-α), on autoimmune dacryoadenitis in a mouse model of Sjögren syndrome (SS) dry eye.MethodsMale nonobese diabetic (NOD) mice were fed chow with or without 0.03% fenofibrate for 8 weeks, and clinical scores were de...